PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

cra_locus_10725_iso_2

Organism

Catharanthus roseus

Taxonomic ID

4058

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus

Family

C2H2

Protein Properties

Length: 492aa MW: 53190.7 Da PI: 6.7271

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
cra_locus_10725_iso_2	genome	MPGR	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	13.8	0.00017	121	146	1	23
EEET..TTTEEESSHHHHHHHHHH.T CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirt.H 23 ++C +C ksF ks++++Hi+ H cra_locus_10725_iso_2_len_2129_ver_3 121 FVCAapHCLKSFLKKSDFVSHINEnH 146 899999****************9988 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00162	0.00923	70	104	No hit	No description
PROSITE pattern	PS00518	0	86	95	IPR017907	Zinc finger, RING-type, conserved site
PROSITE profile	PS50157	9.827	121	151	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	123	146	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 492 aa Download sequence Send to blast
MLQIRLSKPS SEGGATKPLP ADSVTVACPD HLILADLPVA KSLGSPTANA LVKIIGRRSR 60 RQLGERVHFC VHCDLPIAIY GRLSPCEHVF CLDCARSDSL CFLCDERIQK IQTIKMMEGL 120 FVCAAPHCLK SFLKKSDFVS HINENHADLL PPSAEKDGND SEAISARKPA ASDSTVQAPP 180 RPSFSGSNSQ VHDREAYRMQ SRDQPPTRPV MQPKGMPAFP GPIQNHLLEQ QADNNAPPGF 240 DRFGPQNRFA QQTFDSPSGM RQELGQVQDK QQGLVPESPF REYPMQPNQP PNFAVPINPN 300 PAPAQFGYPH FVPDGSQPFY GAYEMARPES TPEVGPEQGS LLGFPPGPAG GMNFGESYPR 360 PWNMGPAVGS FDPSAGPGTV DGFMSASDPQ GRPASFQGDY GRNQGILPSN LPPSSANKGM 420 DSAQGGNSMD PRDGKGILAP QPVSLPPPPP PFAVHLPQAK RGKFYSNEMN NDGQSFGWQN 480 EKRDSFGSSS RD

Sequence ? help Back to Top

Protein Sequence Length: 492 aa Download sequence Send to blast

MLQIRLSKPS SEGGATKPLP ADSVTVACPD HLILADLPVA KSLGSPTANA LVKIIGRRSR  60
RQLGERVHFC VHCDLPIAIY GRLSPCEHVF CLDCARSDSL CFLCDERIQK IQTIKMMEGL  120
FVCAAPHCLK SFLKKSDFVS HINENHADLL PPSAEKDGND SEAISARKPA ASDSTVQAPP  180
RPSFSGSNSQ VHDREAYRMQ SRDQPPTRPV MQPKGMPAFP GPIQNHLLEQ QADNNAPPGF  240
DRFGPQNRFA QQTFDSPSGM RQELGQVQDK QQGLVPESPF REYPMQPNQP PNFAVPINPN  300
PAPAQFGYPH FVPDGSQPFY GAYEMARPES TPEVGPEQGS LLGFPPGPAG GMNFGESYPR  360
PWNMGPAVGS FDPSAGPGTV DGFMSASDPQ GRPASFQGDY GRNQGILPSN LPPSSANKGM  420
DSAQGGNSMD PRDGKGILAP QPVSLPPPPP PFAVHLPQAK RGKFYSNEMN NDGQSFGWQN  480
EKRDSFGSSS RD

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2mq1_A	2e-16	67	146	1	85	E3 ubiquitin-protein ligase Hakai
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:28503769). Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769). N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:28503769). {ECO:0000269\|PubMed:28503769}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_027068481.1	0.0	E3 ubiquitin-protein ligase Hakai-like
Swissprot	Q9LFC0	3e-97	HAKAI_ARATH; E3 ubiquitin-protein ligase HAKAI homolog
TrEMBL	A0A068UD82	0.0	A0A068UD82_COFCA; Uncharacterized protein
STRING	XP_009786415.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA6404	4	5

Publications ? help Back to Top
Růžička K, et al. Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI. New Phytol., 2017. 215(1): p. 157-172 [PMID:28503769]