PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_10414_iso_5
Organism
Catharanthus roseus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family bHLH
Protein Properties Length: 365aa    MW: 40252.6 Da    PI: 8.83
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_10414_iso_5genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH314.5e-10285332455
                                           HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                                   HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                                           +h+ +Er RR++i +++  L++l+P +    +k   Ka +L + ++Y++sLq
  cra_locus_10414_iso_5_len_1608_ver_3 285 SHSLAERVRREKISERMKYLQDLVPGC----NKITGKAGMLDEIINYVQSLQ 332
                                           8**************************....999*****************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.11E-9279336No hitNo description
SuperFamilySSF474594.84E-17279350IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.618281331IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.9E-17281348IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.8E-7285332IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.3E-9287337IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 365 aa     Download sequence    Send to blast
MNTSLPEMLH YLNTPENFNR GGGGGGGGGA AKMSVLERQQ ARNKWQQEQL QLQQLPIDYF  60
GSDAQLNVFS VSAQSQHFQD LSNDQNLGGI LTQAMKPDPG LADGIIHFGS IGRDNSSYGV  120
RGYGNFTSFD VNNAVSRTAS CPPAVAAAMA ELATKGKETV LPEKLSSSSG RESFKKRKAD  180
KNHNPKVCTI SSVNCVLSXW KLTNKKDHIQ AATEEENEEK KLKGNTEEKD AKLTAEQKSI  240
IKNTANNNNN KTEPSDTSKE NSKVSEVQKP DYIHVRARRG QATDSHSLAE RVRREKISER  300
MKYLQDLVPG CNKITGKAGM LDEIINYVQS LQRQVEFLSM KLAAVNPRLD FNIDNLIFPG  360
TTPEX
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. {ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Accumulates strongly in response to blue light due to reduced preventing 26S proteasome-mediated degradation in an ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in the absence of blue light via 26S proteasome degradation (at protein level). {ECO:0000269|PubMed:24101505}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027105742.11e-123transcription factor bHLH63-like isoform X1
RefseqXP_027105743.11e-123transcription factor bHLH63-like isoform X1
RefseqXP_027105746.11e-123transcription factor bHLH63-like isoform X4
RefseqXP_027105747.11e-123transcription factor bHLH63-like isoform X4
RefseqXP_027112240.11e-123transcription factor bHLH63-like isoform X1
RefseqXP_027112241.11e-123transcription factor bHLH63-like isoform X1
RefseqXP_027112244.11e-123transcription factor bHLH63-like isoform X4
RefseqXP_027112245.11e-123transcription factor bHLH63-like isoform X4
SwissprotQ8GY613e-52BH063_ARATH; Transcription factor bHLH63
TrEMBLA0A1D9CFP31e-113A0A1D9CFP3_VACCO; Transcription factor BHLH055 (Fragment)
STRINGXP_009762311.11e-103(Nicotiana sylvestris)
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Yang D,Zhao W,Meng Y,Li H,Liu B
    A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.
    Sci China Life Sci, 2015. 58(3): p. 261-9
    [PMID:25651969]
  3. Katsura Y, et al.
    An optogenetic system for interrogating the temporal dynamics of Akt.
    Sci Rep, 2015. 5: p. 14589
    [PMID:26423353]
  4. Taslimi A, et al.
    Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
    Nat. Chem. Biol., 2016. 12(6): p. 425-30
    [PMID:27065233]
  5. Liu Q, et al.
    The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.
    Plant Cell Physiol., 2016. 57(10): p. 2175-2186
    [PMID:27516416]
  6. Pathak GP, et al.
    Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
    Nucleic Acids Res., 2017. 45(20): p. e167
    [PMID:28431041]
  7. Duan L, et al.
    Understanding CRY2 interactions for optical control of intracellular signaling.
    Nat Commun, 2017. 8(1): p. 547
    [PMID:28916751]
  8. Quejada JR, et al.
    Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1.
    Nucleic Acids Res., 2017. 45(20): p. e172
    [PMID:29040770]
  9. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.
    [PMID:30126927]