PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID evm.model.supercontig_27.246
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Caricaceae; Carica
Family MYB_related
Protein Properties Length: 435aa    MW: 49644.7 Da    PI: 6.3904
Description MYB_related family protein
Gene Model
Gene Model ID Type Source Coding Sequence
evm.model.supercontig_27.246genomeASGPBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding37.94.1e-12107147445
                                   S-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHH CS
               Myb_DNA-binding   4 WTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwq 45 
                                   W ++E+ ll+++++++G g+W+ +a+++g +++ ++c++++ 
  evm.model.supercontig_27.246 107 WNADEEMLLLEGIEMYGLGNWAEVAEHVG-TKSKESCIEHYT 147
                                   *****************************.**********96 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PIRSFPIRSF0250245.0E-13435435IPR016827Transcriptional adaptor 2
PROSITE profilePS5013511.0714390IPR000433Zinc finger, ZZ-type
SMARTSM002912.5E-114388IPR000433Zinc finger, ZZ-type
PfamPF005691.9E-84683IPR000433Zinc finger, ZZ-type
CDDcd023354.25E-264795No hitNo description
SuperFamilySSF578506.36E-1547110No hitNo description
PROSITE patternPS0135704976IPR000433Zinc finger, ZZ-type
SuperFamilySSF466891.27E-12100153IPR009057Homeodomain-like
PROSITE profilePS5129322.714102154IPR017884SANT domain
SMARTSM007171.0E-11103152IPR001005SANT/Myb domain
PfamPF002495.5E-12106147IPR001005SANT/Myb domain
CDDcd001671.96E-11107149No hitNo description
Gene3DG3DSA:1.10.10.602.7E-8107148IPR009057Homeodomain-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006357Biological Processregulation of transcription from RNA polymerase II promoter
GO:0016573Biological Processhistone acetylation
GO:0003677Molecular FunctionDNA binding
GO:0008270Molecular Functionzinc ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 435 aa     Download sequence    Send to blast
MGRSRGNFHS DEDPTQRSRR KKNAPSGENS ESAFAGQGSS EGKRALYHCN YCNKDITGKI  60
RIKCAVCPDF DLCAECFSVG AEVTPHKCNH PYKVMDNLSF PLICPDWNAD EEMLLLEGIE  120
MYGLGNWAEV AEHVGTKSKE SCIEHYTSVY LNSPYFPLPD MSHVVGKNRK ELLAMAKGHS  180
EDKKGSLMLG ELNMKEECPF SPSRVKVEEM HRMGPSGRLL SGGKADAGNR SGSKSMEAAA  240
DVAQVKDGSS IIKVEDPQTD RPFGGKKPNS LGNDNLIEMS GYNPKRQEFD TEYDNDAEQL  300
LAEMEFKDTD TEEERELKLR VLRIYSRRLD ERKRRKDFIL ERNLLYTNPF EKDLSPEERA  360
ICRSYDVFMR FHSKEEHEEL LRSAIEEHRT LKRLQELKEA RAAGCRTSAE ADRYLEQRRK  420
RESEESSRRA KESTQ
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
6cw3_E4e-41471625120Transcriptional adapter 2
6cw3_G4e-41471625120Transcriptional adapter 2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1331336RKRRKD
Functional Description ? help Back to Top
Source Description
UniProtRequired for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity). ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region. Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (PubMed:12615937, PubMed:12747832). Involved in the positive regulation of salt-induced gene expression by maintaining locus-specific acetylation of histones H4 and H3 (PubMed:21193996). {ECO:0000250, ECO:0000269|PubMed:12615937, ECO:0000269|PubMed:12747832, ECO:0000269|PubMed:21193996}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapevm.model.supercontig_27.246
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021902377.10.0LOW QUALITY PROTEIN: transcriptional adapter ADA2b-like
SwissprotQ9ATB40.0TAD2B_ARATH; Transcriptional adapter ADA2b
TrEMBLA0A1Q3AVT00.0A0A1Q3AVT0_CEPFO; Transcriptional adapter
STRINGevm.model.supercontig_27.2460.0(Carica papaya)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM282225
Representative plantOGRP2480912
Publications ? help Back to Top
  1. Vlachonasios KE,Thomashow MF,Triezenberg SJ
    Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression.
    Plant Cell, 2003. 15(3): p. 626-38
    [PMID:12615937]
  2. Sieberer T,Hauser MT,Seifert GJ,Luschnig C
    PROPORZ1, a putative Arabidopsis transcriptional adaptor protein, mediates auxin and cytokinin signals in the control of cell proliferation.
    Curr. Biol., 2003. 13(10): p. 837-42
    [PMID:12747832]
  3. Kerschen A,Napoli CA,Jorgensen RA,Müller AE
    Effectiveness of RNA interference in transgenic plants.
    FEBS Lett., 2004. 566(1-3): p. 223-8
    [PMID:15147899]
  4. Hark AT, et al.
    Two Arabidopsis orthologs of the transcriptional coactivator ADA2 have distinct biological functions.
    Biochim. Biophys. Acta, 2009. 1789(2): p. 117-24
    [PMID:18929690]
  5. Anzola JM, et al.
    Putative Arabidopsis transcriptional adaptor protein (PROPORZ1) is required to modulate histone acetylation in response to auxin.
    Proc. Natl. Acad. Sci. U.S.A., 2010. 107(22): p. 10308-13
    [PMID:20479223]
  6. Kaldis A,Tsementzi D,Tanriverdi O,Vlachonasios KE
    Arabidopsis thaliana transcriptional co-activators ADA2b and SGF29a are implicated in salt stress responses.
    Planta, 2011. 233(4): p. 749-62
    [PMID:21193996]
  7. Vlachonasios KE,Kaldis A,Nikoloudi A,Tsementzi D
    The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses.
    Plant Signal Behav, 2011. 6(10): p. 1475-8
    [PMID:21897124]
  8. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  9. Kazama D,Kurusu T,Mitsuda N,Ohme-Takagi M,Tada Y
    Involvement of elevated proline accumulation in enhanced osmotic stress tolerance in Arabidopsis conferred by chimeric repressor gene silencing technology.
    Plant Signal Behav, 2014. 9(3): p. e28211
    [PMID:24614501]
  10. Kim JY,Oh JE,Noh YS,Noh B
    Epigenetic control of juvenile-to-adult phase transition by the Arabidopsis SAGA-like complex.
    Plant J., 2015. 83(3): p. 537-45
    [PMID:26095998]
  11. Kazama D, et al.
    Identification of Chimeric Repressors that Confer Salt and Osmotic Stress Tolerance in Arabidopsis.
    Plants (Basel), 2013. 2(4): p. 769-85
    [PMID:27137403]
  12. Simon MK,Skinner DJ,Gallagher TL,Gasser CS
    Integument Development in Arabidopsis Depends on Interaction of YABBY Protein INNER NO OUTER with Coactivators and Corepressors.
    Genetics, 2017. 207(4): p. 1489-1500
    [PMID:28971961]
  13. Lai J, et al.
    The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants.
    Plant Physiol., 2018. 176(4): p. 2613-2622
    [PMID:29463775]
  14. Kotak J, et al.
    The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect leaf development and trichome morphogenesis in Arabidopsis.
    Planta, 2018. 248(3): p. 613-628
    [PMID:29846775]