PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MELO3C025070P2
Organism
Cucumis melo
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family ARF
Protein Properties Length: 676aa    MW: 74921.9 Da    PI: 6.2291
Description ARF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MELO3C025070P2genomeMELONOMICSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1B333.86e-115524899
                    EEE..EEETTEEEE-TTHHHHHHHHT--TT-EEEEEE-SSSEE..EEEEE-S CS
              B3 48 vkliyrkksgryvltkGWkeFvkangLkegDfvvFkldgrsefelvvkvfrk 99
                    + +  +++++r++lt+GW+ Fv+a++L +gD+v+F   ++++ +l+++++r+
  MELO3C025070P2  5 FVV--TGQPKRHLLTTGWSVFVSAKRLVAGDSVLFI--WNEKNQLLLGIRRA 52
                    455..88999**************************..8899999****997 PP
2Auxin_resp1201.9e-3977160183
      Auxin_resp   1 aahaastksvFevvYnPrastseFvvkvekvekalk.vkvsvGmRfkmafetedsserrlsGtvvgvsdldpvrWpnSkWrsLk 83 
                     aahaa+t+s F+v+YnPras+seFv+++ k++ka+  ++vsvGmRf+m fete+ss rr++Gt++g+sdldpvrWpnS+Wrs+k
  MELO3C025070P2  77 AAHAAATNSCFTVFYNPRASPSEFVIPLTKYVKAVFhTRVSVGMRFRMLFETEESSVRRYMGTITGISDLDPVRWPNSHWRSVK 160
                     79********************************86599******************************************985 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5086310.123153IPR003340B3 DNA binding domain
PfamPF023621.4E-8552IPR003340B3 DNA binding domain
CDDcd100179.01E-6551No hitNo description
Gene3DG3DSA:2.40.330.101.8E-15866IPR015300DNA-binding pseudobarrel domain
SuperFamilySSF1019364.19E-13980IPR015300DNA-binding pseudobarrel domain
PfamPF065071.7E-3477160IPR010525Auxin response factor
SuperFamilySSF542776.87E-8542624No hitNo description
PfamPF023093.2E-8547634IPR033389AUX/IAA domain
PROSITE profilePS5174526.593550634IPR000270PB1 domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009733Biological Processresponse to auxin
GO:0009908Biological Processflower development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0005515Molecular Functionprotein binding
Sequence ? help Back to Top
Protein Sequence    Length: 676 aa     Download sequence    Send to blast
MAYLFVVTGQ PKRHLLTTGW SVFVSAKRLV AGDSVLFIWN EKNQLLLGIR RATRPQTVMP  60
SSVLSSDSMH IGLLAAAAHA AATNSCFTVF YNPRASPSEF VIPLTKYVKA VFHTRVSVGM  120
RFRMLFETEE SSVRRYMGTI TGISDLDPVR WPNSHWRSVK VGWDESTAGE RQPRVSLWEI  180
EPLTTFPMYP SLFPLRMKRP WHPGVSSVHD NRDDASNGLM WLRGGVGEQG LHSLNLQSVG  240
SLPWLQQRLD SSMFGNDHNQ QYQAMLAAGM PNLGGVDMLR QQIMHLQQPF QYIPQAGFHN  300
SLLQMQQQQQ QQQQQQQQLV QQSMPQNILQ APSQVMAENL PPHILQQTLQ NQPEDLPNQQ  360
QHTYHDTIQV QGNQFHQGGH SNVPSPTFPR TDLMDSNTSY SESITSRRNI LASSCAEGTG  420
NLPTIYRSGQ SILTEHLPQQ SSVSKNAHSQ VDAHPNSMSF PPFSGRDSIL ELGNCNSDSP  480
SPTLFGVNID SSGLLLPSNV PTYSSPSIGP DSSSIPMGDS GFQNSLYSCV QDSSELLHNS  540
GQVDPSNPTR TFVKVYKSGS VGRSLDISRF SSYQELREEL AQMFGIEGQL EDPHRSGWQL  600
VFVDRENDVL LLGDDPWEAF VNNVGYIKIL SPEDFQKLGE QAIESFNPIV GQRLTSGGNE  660
AGNVSGLPSV GSLEY*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4ldu_A3e-712181209388Auxin response factor 5
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtAuxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Regulates both stamen and gynoecium maturation. Promotes jasmonic acid production. Partially redundant with ARF6. Involved in fruit initiation. Acts as an inhibitor to stop further carpel development in the absence of fertilization and the generation of signals required to initiate fruit and seed development. {ECO:0000269|PubMed:12036261, ECO:0000269|PubMed:16107481, ECO:0000269|PubMed:16829592}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00033PBMTransfer from AT5G37020Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by miR167. {ECO:0000269|PubMed:17021043}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKU3234070.0KU323407.1 UNVERIFIED: Trichosanthes dioica clone TdARF_5 auxin response factor 8-like mRNA, partial sequence.
GenBankKU3234210.0KU323421.1 UNVERIFIED: Trichosanthes dioica clone TdARF_29 auxin response factor 8-like mRNA, partial sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008463127.10.0PREDICTED: auxin response factor 8
SwissprotQ9FGV10.0ARFH_ARATH; Auxin response factor 8
TrEMBLA0A1S3CIX20.0A0A1S3CIX2_CUCME; Auxin response factor
STRINGXP_008463127.10.0(Cucumis melo)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G37020.10.0auxin response factor 8
Publications ? help Back to Top
  1. Liu N, et al.
    Down-regulation of AUXIN RESPONSE FACTORS 6 and 8 by microRNA 167 leads to floral development defects and female sterility in tomato.
    J. Exp. Bot., 2014. 65(9): p. 2507-20
    [PMID:24723401]
  2. Minato N, et al.
    The phytoplasmal virulence factor TENGU causes plant sterility by downregulating of the jasmonic acid and auxin pathways.
    Sci Rep, 2014. 4: p. 7399
    [PMID:25492247]
  3. Ortega-Amaro MA, et al.
    Overexpression of AtGRDP2, a novel glycine-rich domain protein, accelerates plant growth and improves stress tolerance.
    Front Plant Sci, 2014. 5: p. 782
    [PMID:25653657]
  4. Wang Y, et al.
    MicroRNA167-Directed Regulation of the Auxin Response Factors GmARF8a and GmARF8b Is Required for Soybean Nodulation and Lateral Root Development.
    Plant Physiol., 2015. 168(3): p. 984-99
    [PMID:25941314]
  5. Barik S, et al.
    Coevolution Pattern and Functional Conservation or Divergence of miR167s and their targets across Diverse Plant Species.
    Sci Rep, 2015. 5: p. 14611
    [PMID:26459056]
  6. Pashkovskiy PP,Kartashov AV,Zlobin IE,Pogosyan SI,Kuznetsov VV
    Blue light alters miR167 expression and microRNA-targeted auxin response factor genes in Arabidopsis thaliana plants.
    Plant Physiol. Biochem., 2016. 104: p. 146-54
    [PMID:27031426]
  7. Mlotshwa S,Pruss GJ,MacArthur JL,Reed JW,Vance V
    Developmental Defects Mediated by the P1/HC-Pro Potyviral Silencing Suppressor Are Not Due to Misregulation of AUXIN RESPONSE FACTOR 8.
    Plant Physiol., 2016. 172(3): p. 1853-1861
    [PMID:27688620]
  8. Wójcikowska B,Gaj MD
    Expression profiling of AUXIN RESPONSE FACTOR genes during somatic embryogenesis induction in Arabidopsis.
    Plant Cell Rep., 2017. 36(6): p. 843-858
    [PMID:28255787]
  9. Zhang GZ, et al.
    Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis.
    Plant Cell Rep., 2017. 36(12): p. 1995-2006
    [PMID:29027578]
  10. Zheng K, et al.
    Involvement of PACLOBUTRAZOL RESISTANCE6/KIDARI, an Atypical bHLH Transcription Factor, in Auxin Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1813
    [PMID:29114256]
  11. Liu Z, et al.
    ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis.
    Plant Cell Physiol., 2018. 59(1): p. 179-189
    [PMID:29145642]
  12. Ghelli R, et al.
    A Newly Identified Flower-Specific Splice Variant of AUXIN RESPONSE FACTOR8 Regulates Stamen Elongation and Endothecium Lignification in Arabidopsis.
    Plant Cell, 2018. 30(3): p. 620-637
    [PMID:29514943]