PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Cla018429

Organism

Citrullus lanatus

Taxonomic ID

3654

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus

Family

E2F/DP

Protein Properties

Length: 471aa MW: 52536.7 Da PI: 5.2328

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cla018429	genome	ICuGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	81.1	9.8e-26	142	207	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++++gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn i wkg Cla018429 142 RYDSSLGLLTKKFINLIKQARDGILDLNKAAETL---QV--QKRRIYDITNVLEGIGLIEKKLKNIIYWKG 207 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	5.5E-28	139	209	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.1E-31	142	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	8.3E-17	142	205	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.7E-23	144	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	1.05E-32	221	324	No hit	No description
CDD	cd14660	7.25E-45	223	324	No hit	No description
Pfam	PF16421	1.3E-31	223	322	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 471 aa Download sequence Send to blast
MRGASRAPNR SEPLPQSQTA QILPPLKRHL AFDSAKPPFA PPGHYYHFGG GSSNAIDQQP 60 DSIVVKPLKP KQKGVMYNNV VESNDYSHDQ GSSLSSVQTP VSGKGGRVYN KSKTSRKTTS 120 GPQTPISDTS TYSPLTPAGN CRYDSSLGLL TKKFINLIKQ ARDGILDLNK AAETLQVQKR 180 RIYDITNVLE GIGLIEKKLK NIIYWKGFNQ QIPGNVDSDT SMLQVDVENL SFEERRLDDK 240 IRVMQERLRN LSEDENIQKW LFVTEEDIKN LPCFQNETLI AIKAPHGTTL EVPDPDEAVD 300 YPQRRYRIVL RSTMGPIDVY LVSQFEEKFE EMNVVPPPSS FLHASSSGSN EHLATEAIIG 360 ESSRNEIEPQ AHLSQHSSSC DVNGSNEFPV GMMKIIPSDV DNDADYWLLS DAEVSITDMW 420 RTDSTADIAW DQSDMVPHDF LISDVSAQRP RPGSPHSETA EAPSDVNLRQ R

Sequence ? help Back to Top

Protein Sequence Length: 471 aa Download sequence Send to blast

MRGASRAPNR SEPLPQSQTA QILPPLKRHL AFDSAKPPFA PPGHYYHFGG GSSNAIDQQP  60
DSIVVKPLKP KQKGVMYNNV VESNDYSHDQ GSSLSSVQTP VSGKGGRVYN KSKTSRKTTS  120
GPQTPISDTS TYSPLTPAGN CRYDSSLGLL TKKFINLIKQ ARDGILDLNK AAETLQVQKR  180
RIYDITNVLE GIGLIEKKLK NIIYWKGFNQ QIPGNVDSDT SMLQVDVENL SFEERRLDDK  240
IRVMQERLRN LSEDENIQKW LFVTEEDIKN LPCFQNETLI AIKAPHGTTL EVPDPDEAVD  300
YPQRRYRIVL RSTMGPIDVY LVSQFEEKFE EMNVVPPPSS FLHASSSGSN EHLATEAIIG  360
ESSRNEIEPQ AHLSQHSSSC DVNGSNEFPV GMMKIIPSDV DNDADYWLLS DAEVSITDMW  420
RTDSTADIAW DQSDMVPHDF LISDVSAQRP RPGSPHSETA EAPSDVNLRQ R

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	4e-24	137	209	2	75	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681876	1e-104	LN681876.1 Cucumis melo genomic scaffold, anchoredscaffold00068.
GenBank	LN713262	1e-104	LN713262.1 Cucumis melo genomic chromosome, chr_8.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011657728.1	0.0	PREDICTED: transcription factor E2FA-like isoform X4
Swissprot	Q9FNY0	1e-148	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A0A0KF09	0.0	A0A0A0KF09_CUCSA; Uncharacterized protein
STRING	XP_004143395.1	0.0	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-153	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]