PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cc10_g01770
Common NameGSCOC_T00024664001
Organism
Coffea canephora
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Coffeeae; Coffea
Family E2F/DP
Protein Properties Length: 434aa    MW: 47608.6 Da    PI: 5.3103
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cc10_g01770genomeCGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.82.8e-26177242171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf+kl++++e+g ++ln +a+ L   +v  ++RRiYDi+NVLe+++liek+ k++irwkg
  Cc10_g01770 177 RYDSSLGLLTKKFIKLIREAEDGCLDLNRAADLL---EV--QKRRIYDITNVLEGVGLIEKTTKSHIRWKG 242
                  6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.5E-27175243IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.7E-34177242IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.8E-17177240IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023196.3E-24179242IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146609.49E-29253354No hitNo description
SuperFamilySSF1440741.18E-18256353No hitNo description
PfamPF164216.8E-18258351IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 434 aa     Download sequence    Send to blast
MSTSGDGRGR GRHIDIDLNV SLNSSFGNLS LAASAVPPPP RLEPQHRFSV PVVPSSVCER  60
LDPFASIHSP PAAADPSAII NYCIAPNFLD IQPKDSFTSW NSPSLLGLPH TNEHGIFEGN  120
KGTSKTSSVH DASLKLPVSL LEAKQCSKAR GSNHVKPGTL EPNAEVLDNV GVVGSCRYDS  180
SLGLLTKKFI KLIREAEDGC LDLNRAADLL EVQKRRIYDI TNVLEGVGLI EKTTKSHIRW  240
KGYEMFGPEE LNNQAIILKA EIECLFAEDC RLDDCIRFDN HHMEECLLTL YLTEEDIMSQ  300
PCFRNKTVIA VKAPHASTLE VPDPDEDIRF SERQYKLIVR STIGPIDLYL LSNHGGHHED  360
VKVKRRKLLD SSVVNGCRQG ADDAYYSDAS GLQSSDVSGI NKIIPSDGAV NDDYWLRSDN  420
AVTATDLWGT ECS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-22177242773PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027092083.10.0transcription factor E2FC-like
RefseqXP_027094734.10.0transcription factor E2FC-like
SwissprotQ9FV702e-76E2FC_ARATH; Transcription factor E2FC
SwissprotQ9FV711e-75E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A068UGJ40.0A0A068UGJ4_COFCA; Uncharacterized protein
STRINGVIT_18s0001g14110.t011e-114(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA126252022
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.33e-74E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  4. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  5. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]