PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ciclev10001979m
Common NameCICLE_v10001979mg
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family MYB
Protein Properties Length: 303aa    MW: 32948.9 Da    PI: 8.2884
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ciclev10001979mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding59.47.9e-191257147
                     TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47
                     +g+W++eEde l ++v+ +G+++W++I++ ++ gR++k+c++rw + 
  Ciclev10001979m 12 KGPWSPEEDEALQRLVQNYGPRNWSLISKSIP-GRSGKSCRLRWCNQ 57
                     79******************************.***********985 PP

2Myb_DNA-binding55.61.3e-1766108347
                      SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS
  Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47 
                      ++T+eEde +++a++++G++ W+tIar +  gRt++ +k++w++ 
  Ciclev10001979m  66 PFTPEEDETILRAHARFGNK-WATIARLLS-GRTDNAIKNHWNST 108
                      89******************.*********.***********986 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129426.417762IPR017930Myb domain
SuperFamilySSF466892.05E-329105IPR009057Homeodomain-like
SMARTSM007171.1E-161160IPR001005SANT/Myb domain
PfamPF002491.8E-181257IPR001005SANT/Myb domain
Gene3DG3DSA:1.10.10.601.2E-261365IPR009057Homeodomain-like
CDDcd001674.12E-161456No hitNo description
SMARTSM007177.1E-1563111IPR001005SANT/Myb domain
PROSITE profilePS5129421.26564113IPR017930Myb domain
Gene3DG3DSA:1.10.10.608.0E-2466112IPR009057Homeodomain-like
CDDcd001672.90E-1266109No hitNo description
PfamPF002497.6E-1566108IPR001005SANT/Myb domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 303 aa     Download sequence    Send to blast
MASTKKDVDR IKGPWSPEED EALQRLVQNY GPRNWSLISK SIPGRSGKSC RLRWCNQLSP  60
QVEHRPFTPE EDETILRAHA RFGNKWATIA RLLSGRTDNA IKNHWNSTLK RKCSSMSDES  120
QVDAINPLPL KRANSVGPSN NISGLCLNPG SPSGSDSSDS SLPGVAQSPV CHPLFRTGSL  180
VPVETSSSTT DPPTSLSLSL PGSESCEVSN HGPGSENGSN LVLNPNQVAS TQPLQVQAQA  240
QNQGEFGYEK QFFNPEFLAV MQEMIRKEVR NYMSGVERNG LCLPAEAIRN AVVKRIGINK  300
AD*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1gv2_A9e-42111133105MYB PROTO-ONCOGENE PROTEIN
1h88_C5e-411111357159MYB PROTO-ONCOGENE PROTEIN
1h89_C5e-411111357159MYB PROTO-ONCOGENE PROTEIN
1mse_C9e-42111133105C-Myb DNA-Binding Domain
1msf_C9e-42111133105C-Myb DNA-Binding Domain
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ccl.6140.0vegetative tissue
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed during very late stages of embryogenesis. Later, its expression follows a development dependent gradient in successive leaves. {ECO:0000269|PubMed:9678577}.
UniprotTISSUE SPECIFICITY: Expressed in roots, stems, leaves, inflorescence, and flowers (including stamen, floral nectar, carpel, petal and sepal), mostly in vasculatures and stomata. {ECO:0000269|PubMed:18162593, ECO:0000269|PubMed:9678577}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor (PubMed:23067202, PubMed:23603962). Represses the expression of protein phosphatases 2C in response to abscisic acid (ABA). Confers resistance to abiotic stresses dependent of ABA (PubMed:18162593, PubMed:9678577). In response to auxin, activates the transcription of the auxin-responsive gene IAA19. The IAA19 transcription activation by MYB44 is enhanced by direct interaction between MYB44 and PYL8 (PubMed:24894996). Transcriptional activator of WRKY70 by direct binding to its promoter region, especially at 5'-TAACNG-3' and 5'-CNGTTA-3' symmetric motifs (PubMed:23067202, PubMed:23603962). Activates salicylic acid (SA)- mediated defenses and subsequent resistance to biotrophic pathogen P.syringae pv. tomato DC3000, but represses jasmonic acid (JA)-mediated defenses responses against the necrotrophic pathogen A.brassicicola (PubMed:23067202). {ECO:0000269|PubMed:18162593, ECO:0000269|PubMed:23067202, ECO:0000269|PubMed:23603962, ECO:0000269|PubMed:24894996, ECO:0000269|PubMed:9678577}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By drought, cold, high salinity, cadmium (CdCl(2)), salicylic acid (SA), jasmonate (JA), ethylene, gibberellic acid (GA), and ABA (PubMed:16463103, PubMed:18162593, PubMed:23067202). The induction by JA is COI1-dependent (PubMed:23067202). {ECO:0000269|PubMed:16463103, ECO:0000269|PubMed:18162593, ECO:0000269|PubMed:23067202}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHQ8410740.0HQ841074.1 Citrus sinensis putative R2R3-MYB transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006434697.10.0transcription factor MYB44
SwissprotQ9FDW11e-92MYB44_ARATH; Transcription factor MYB44
TrEMBLV4T4240.0V4T424_9ROSI; Uncharacterized protein
STRINGXP_006434697.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM67728135
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G67300.12e-75myb domain protein r1
Publications ? help Back to Top
  1. Li C,Chang PP,Ghebremariam KM,Qin L,Liang Y
    Overexpression of tomato SpMPK3 gene in Arabidopsis enhances the osmotic tolerance.
    Biochem. Biophys. Res. Commun., 2014. 443(2): p. 357-62
    [PMID:24275141]
  2. Jaradat MR,Feurtado JA,Huang D,Lu Y,Cutler AJ
    Multiple roles of the transcription factor AtMYBR1/AtMYB44 in ABA signaling, stress responses, and leaf senescence.
    BMC Plant Biol., 2013. 13: p. 192
    [PMID:24286353]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Li D, et al.
    Arabidopsis ABA receptor RCAR1/PYL9 interacts with an R2R3-type MYB transcription factor, AtMYB44.
    Int J Mol Sci, 2014. 15(5): p. 8473-90
    [PMID:24828206]
  5. Xu DB, et al.
    A G-protein β subunit, AGB1, negatively regulates the ABA response and drought tolerance by down-regulating AtMPK6-related pathway in Arabidopsis.
    PLoS ONE, 2015. 10(1): p. e0116385
    [PMID:25635681]
  6. Hieno A, et al.
    Possible Involvement of MYB44-Mediated Stomatal Regulation in Systemic Resistance Induced by Penicillium simplicissimum GP17-2 in Arabidopsis.
    Microbes Environ., 2016. 31(2): p. 154-9
    [PMID:27301421]
  7. Zhao Q, et al.
    AtMYB44 Positively Regulates the Enhanced Elongation of Primary Roots Induced by N-3-Oxo-Hexanoyl-Homoserine Lactone in Arabidopsis thaliana.
    Mol. Plant Microbe Interact., 2016. 29(10): p. 774-785
    [PMID:27604593]
  8. Song L, et al.
    A transcription factor hierarchy defines an environmental stress response network.
    Science, 2017.
    [PMID:27811239]
  9. Nguyen NH,Cheong JJ
    H2A.Z-containing nucleosomes are evicted to activate AtMYB44 transcription in response to salt stress.
    Biochem. Biophys. Res. Commun., 2018. 499(4): p. 1039-1043
    [PMID:29649476]
  10. Nguyen NH,Cheong JJ
    AtMYB44 interacts with TOPLESS-RELATED corepressors to suppress protein phosphatase 2C gene transcription.
    Biochem. Biophys. Res. Commun., 2018. 507(1-4): p. 437-442
    [PMID:30448055]