PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Csa19g035800.1
Organism
Camelina sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Camelina
Family bHLH
Protein Properties Length: 417aa    MW: 46465.6 Da    PI: 5.3291
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Csa19g035800.1genomeCSGPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH382.9e-12197248155
                     CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                     +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  Csa19g035800.1 197 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 248
                     79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.5E-13195251IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.46E-13195252No hitNo description
PROSITE profilePS5088815.428196247IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.49E-16196261IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.3E-9197248IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9202253IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516718.596330405IPR002912ACT domain
CDDcd048730.00207330394No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008152Biological Processmetabolic process
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 417 aa     Download sequence    Send to blast
MDKDYSAPNF LGESSGGNDD NSSGMIDYMF NRNLQQQQKQ SMPQQQQHQL SPTGFGGTPS  60
FDKMNFADVM QFADFGPKLA LNQTRNQDDQ ETGIDPVYFL KFPVLNNKTE DHNQTQHLMP  120
SHQTSHEGGD CGGNIGNVFL EEREDQDDDN DNNSVQLRFI GGGEEEDREN KNVTTKEVKS  180
KRKRARTSKT SEEVESQRMT HIAVERNRRK QMNEHLRVLR SLMPGSYVQR GDQASIIGGA  240
IEFVRELEQL LQCLESQKRR RILGETGRDM TTTTTSSSSP VTAVANQAQP LIINGHVTEL  300
EGGGGLREET AENKSCLADV EVKLLGFDAM IKILSRRRPG QLIKTIAALE DLHLSILHTN  360
ITTMEQTVLY SFNVKITSET RFTAEDIASS IQQIFSFIHA NTTISASSNL GNAVYA*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1197208RMTHIAVERNRR
2257261KRRRI
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapCsa19g035800.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK2213240.0AK221324.1 Arabidopsis thaliana mRNA for putative bHLH transcription factor, complete cds, clone: RAFL25-14-O10.
GenBankBT0289610.0BT028961.1 Arabidopsis thaliana At3g24140 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010488493.10.0PREDICTED: transcription factor FAMA
RefseqXP_010488494.10.0PREDICTED: transcription factor FAMA
SwissprotQ56YJ80.0FAMA_ARATH; Transcription factor FAMA
TrEMBLD7L4810.0D7L481_ARALL; Uncharacterized protein
STRINGXP_010488493.10.0(Camelina sativa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM55482649
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.10.0bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]