PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Csa12g074460.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Camelina
Family ARF
Protein Properties Length: 896aa    MW: 99313.4 Da    PI: 5.9081
Description ARF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Csa12g074460.1genomeCSGPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1B3733.6e-23242343199
                     EEEE-..-HHHHTT-EE--HHH.HTT......---..--SEEEEEETTS-EEEEEE..EEETTEEEE-TTHHHHHHHHT--TT-EEEEEE-SSSE CS
              B3   1 ffkvltpsdvlksgrlvlpkkfaeeh......ggkkeesktltledesgrsWevkliyrkksgryvltkGWkeFvkangLkegDfvvFkldgrse 89 
                     f+k+lt sd++++g +++p++ ae+        ++++  ++l+ +d++  +W++++i+r++++r++lt+GW+ Fv+a++L +gD+v+F   ++++
  Csa12g074460.1 242 FCKTLTASDTSTHGGFSVPRRAAEKVfppldyTLQPPA-QELIARDLHDVEWKFRHIFRGQPKRHLLTTGWSVFVSAKRLVAGDSVIFI--RNEK 333
                     99*****************************9666655.49************************************************..5688 PP

                     E..EEEEE-S CS
              B3  90 felvvkvfrk 99 
                      +l+++++r+
  Csa12g074460.1 334 NQLFLGIRRA 343
                     889***9997 PP

2Auxin_resp26.52.9e-103854105883
      Auxin_resp  58 rlsGtvvgvsdldpvrWpnSkWrsLk 83 
                     r++Gt++g+sdld+vrWpnS+Wrs+k
  Csa12g074460.1 385 RYMGTITGISDLDTVRWPNSHWRSVK 410
                     79*********************985 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019367.98E-28112183IPR015300DNA-binding pseudobarrel domain
Gene3DG3DSA:2.40.330.102.8E-17119183IPR015300DNA-binding pseudobarrel domain
CDDcd100178.28E-8125183No hitNo description
SMARTSM010190.027126214IPR003340B3 DNA binding domain
SuperFamilySSF1019361.19E-47228371IPR015300DNA-binding pseudobarrel domain
Gene3DG3DSA:2.40.330.104.8E-40235357IPR015300DNA-binding pseudobarrel domain
CDDcd100174.38E-21241337No hitNo description
SMARTSM010192.7E-23242344IPR003340B3 DNA binding domain
PROSITE profilePS5086312.308242344IPR003340B3 DNA binding domain
PfamPF023625.3E-21242343IPR003340B3 DNA binding domain
PfamPF065074.2E-6385410IPR010525Auxin response factor
SuperFamilySSF542773.27E-7783863No hitNo description
PfamPF023096.8E-8785874IPR033389AUX/IAA domain
PROSITE profilePS5174522.8789873IPR000270PB1 domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009725Biological Processresponse to hormone
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0005515Molecular Functionprotein binding
Sequence ? help Back to Top
Protein Sequence    Length: 896 aa     Download sequence    Send to blast
MKLSSSGLGQ QGHEGEKCLN SELWHACAGP LVSLPSSGSR VVYFPQGHSE QVAATTNKEV  60
DGHIPNYPSL PPQLICQLHN VTMHADVETD EVYAQMTLQP LTPEEQKETF VPIELGIPSK  120
QPSNYFCKTL TASDTSTHGG FSVPRRAAEK VFPPLDYTLQ PPAQELIARD LHDVEWKFRH  180
IFRVFGMMCF VSMGFVSTFQ ADVETDEVYA QMTLQPLTPE EQKETFVPIE LGIPSKQPSN  240
YFCKTLTASD TSTHGGFSVP RRAAEKVFPP LDYTLQPPAQ ELIARDLHDV EWKFRHIFRG  300
QPKRHLLTTG WSVFVSAKRL VAGDSVIFIR NEKNQLFLGI RRATRPQTIV PSSVLSSDSM  360
HIGLLAAAAH ASATNSCFTV FFHPRYMGTI TGISDLDTVR WPNSHWRSVK VGWDESTAGE  420
RQPRVSLWEI EPLTTFPMYP SLFPLRLKRP WHAGTSSLPD GRGELGSGLT WLRGGGGEQQ  480
GLLPLNYPSV GLFPWMQQRL DLTQMGTDNN QQYQAMLAAG LQNIGGGDPL RQQFVQLQEP  540
HHQYLQQSAS HNSDLMLQQQ QQQASRHPMH GQPQIMSENI PQQSMRQEVS NHPTGQQLQQ  600
PDQNAYLNAF KMQNGHLQQW QHSDMPSPSF MKSDFTDSSN KFATSATPMQ QNNASPASGD  660
GSNLLNFSIT GQSVLPEQLT TEGWSPKASN TFSEPLSLPQ AYPGKSLALE PGNPNLNPQN  720
PSLFGVDPDS GLFLPSTVPR FGSSSGDAEA SPMSLTDSGF QNSLYGCMQD TTHELLHGAG  780
QINPSTQTKN FVKVYKSGSV GRSLDISRFS SYHELREELG KMFAIEGLLE DPLRSGWQLV  840
FVDKENDILL LGDDPWESFV NNVWYIKILS PEDVQQMGDQ GEGSGGSFPQ NPTHL*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4ldu_A2e-89843140388Auxin response factor 5
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtAuxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Regulates both stamen and gynoecium maturation. Promotes jasmonic acid production. Partially redundant with ARF6. Involved in fruit initiation. Acts as an inhibitor to stop further carpel development in the absence of fertilization and the generation of signals required to initiate fruit and seed development. {ECO:0000269|PubMed:12036261, ECO:0000269|PubMed:16107481, ECO:0000269|PubMed:16829592}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapCsa12g074460.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by miR167. {ECO:0000269|PubMed:17021043}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF0421960.0AF042196.1 Arabidopsis thaliana auxin response factor 8 (ARF8) mRNA, complete cds.
GenBankAY6697900.0AY669790.1 Arabidopsis thaliana clone C105345 ARF8 (At5g37020) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010450468.10.0PREDICTED: auxin response factor 8 isoform X2
SwissprotQ9FGV10.0ARFH_ARATH; Auxin response factor 8
TrEMBLR0GF160.0R0GF16_9BRAS; Auxin response factor
STRINGXP_010450468.10.0(Camelina sativa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM13442894
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G37020.10.0auxin response factor 8
Publications ? help Back to Top
  1. Liu N, et al.
    Down-regulation of AUXIN RESPONSE FACTORS 6 and 8 by microRNA 167 leads to floral development defects and female sterility in tomato.
    J. Exp. Bot., 2014. 65(9): p. 2507-20
    [PMID:24723401]
  2. Minato N, et al.
    The phytoplasmal virulence factor TENGU causes plant sterility by downregulating of the jasmonic acid and auxin pathways.
    Sci Rep, 2014. 4: p. 7399
    [PMID:25492247]
  3. Ortega-Amaro MA, et al.
    Overexpression of AtGRDP2, a novel glycine-rich domain protein, accelerates plant growth and improves stress tolerance.
    Front Plant Sci, 2014. 5: p. 782
    [PMID:25653657]
  4. Wang Y, et al.
    MicroRNA167-Directed Regulation of the Auxin Response Factors GmARF8a and GmARF8b Is Required for Soybean Nodulation and Lateral Root Development.
    Plant Physiol., 2015. 168(3): p. 984-99
    [PMID:25941314]
  5. Barik S, et al.
    Coevolution Pattern and Functional Conservation or Divergence of miR167s and their targets across Diverse Plant Species.
    Sci Rep, 2015. 5: p. 14611
    [PMID:26459056]
  6. Pashkovskiy PP,Kartashov AV,Zlobin IE,Pogosyan SI,Kuznetsov VV
    Blue light alters miR167 expression and microRNA-targeted auxin response factor genes in Arabidopsis thaliana plants.
    Plant Physiol. Biochem., 2016. 104: p. 146-54
    [PMID:27031426]
  7. Mlotshwa S,Pruss GJ,MacArthur JL,Reed JW,Vance V
    Developmental Defects Mediated by the P1/HC-Pro Potyviral Silencing Suppressor Are Not Due to Misregulation of AUXIN RESPONSE FACTOR 8.
    Plant Physiol., 2016. 172(3): p. 1853-1861
    [PMID:27688620]
  8. Wójcikowska B,Gaj MD
    Expression profiling of AUXIN RESPONSE FACTOR genes during somatic embryogenesis induction in Arabidopsis.
    Plant Cell Rep., 2017. 36(6): p. 843-858
    [PMID:28255787]
  9. Zhang GZ, et al.
    Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis.
    Plant Cell Rep., 2017. 36(12): p. 1995-2006
    [PMID:29027578]
  10. Zheng K, et al.
    Involvement of PACLOBUTRAZOL RESISTANCE6/KIDARI, an Atypical bHLH Transcription Factor, in Auxin Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1813
    [PMID:29114256]
  11. Liu Z, et al.
    ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis.
    Plant Cell Physiol., 2018. 59(1): p. 179-189
    [PMID:29145642]
  12. Ghelli R, et al.
    A Newly Identified Flower-Specific Splice Variant of AUXIN RESPONSE FACTOR8 Regulates Stamen Elongation and Endothecium Lignification in Arabidopsis.
    Plant Cell, 2018. 30(3): p. 620-637
    [PMID:29514943]