PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_004510118.2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Cicereae; Cicer
Family MYB
Protein Properties Length: 309aa    MW: 35408.8 Da    PI: 7.8912
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_004510118.2genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding43.86.1e-141661146
                     TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46
                     +g+W  eEde lv+ vk++G+++W++I ++  + Rt+k+c++rw +
   XP_004510118.2 16 KGPWKSEEDEVLVQHVKKYGPRDWSSIRSKGLLLRTGKSCRLRWVN 61
                     79*************************8887799**********87 PP

2Myb_DNA-binding42.81.2e-1372111344
                      SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS
  Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 
                      +++ eE+ + +d+ +++G++ W++Ia+ ++ gRt++++k++w
   XP_004510118.2  72 KFSVEEERIVIDLQREFGNR-WAKIASSLP-GRTDNDVKNFW 111
                      799*****************.*********.*********** PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.601.5E-20964IPR009057Homeodomain-like
PROSITE profilePS5129421.3221167IPR017930Myb domain
SuperFamilySSF466891.22E-2713111IPR009057Homeodomain-like
SMARTSM007173.1E-111565IPR001005SANT/Myb domain
PfamPF002491.4E-111661IPR001005SANT/Myb domain
CDDcd001671.12E-111863No hitNo description
Gene3DG3DSA:1.10.10.609.6E-1865117IPR009057Homeodomain-like
PROSITE profilePS5129417.82868119IPR017930Myb domain
SMARTSM007172.7E-1369117IPR001005SANT/Myb domain
CDDcd001674.00E-1172111No hitNo description
PfamPF002494.5E-1272111IPR001005SANT/Myb domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0048235Biological Processpollen sperm cell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 309 aa     Download sequence    Send to blast
MKMHRGKKEQ DDNIRKGPWK SEEDEVLVQH VKKYGPRDWS SIRSKGLLLR TGKSCRLRWV  60
NKLRPNLKNG CKFSVEEERI VIDLQREFGN RWAKIASSLP GRTDNDVKNF WSSRQKRLAR  120
LLKTSSSSTT TLKSHKNKTK VSASVPTSKA PKFSSSSEGE SSTRPQSCSL PCIENSEQVI  180
QMVPLADLIK TEQPIFDTSY VEQEFNPFAS NEHIAFPQIS ELQTDLTFPM ESQQDLFGRV  240
DDQNLFDVFG PLDSSEFGMV PQHPLKFPFF DPSESCRIDS NRNIDSFFDD FPQYMFDDID  300
QPPSSPSKL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1h8a_C5e-30411715126MYB TRANSFORMING PROTEIN
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269|PubMed:15618418, ECO:0000269|PubMed:15694308, ECO:0000269|PubMed:19300502, ECO:0000269|PubMed:21285328, ECO:0000269|PubMed:24876252}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_004510118.2
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269|PubMed:21441434, ECO:0000269|PubMed:25057814}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAP0150421e-48AP015042.1 Vigna angularis var. angularis DNA, chromosome 9, almost complete sequence, cultivar: Shumari.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004510118.20.0transcription factor DUO1
SwissprotA0A178VEK72e-83DUO1_ARATH; Transcription factor DUO1
TrEMBLA0A1S2YUE50.0A0A1S2YUE5_CICAR; transcription factor DUO1
STRINGXP_004510118.10.0(Cicer arietinum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36933164
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G60460.17e-79MYB family protein
Publications ? help Back to Top
  1. Zheng B,He H,Zheng Y,Wu W,McCormick S
    An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana.
    PLoS Genet., 2014. 10(7): p. e1004421
    [PMID:25057814]
  2. Peters B, et al.
    A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter.
    Plant Physiol., 2017. 173(1): p. 280-293
    [PMID:27624837]
  3. Zheng Z, et al.
    Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy.
    Plant Physiol., 2017. 174(3): p. 1764-1778
    [PMID:28515145]