PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_004497676.1

Organism

Cicer arietinum

Taxonomic ID

3827

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Cicereae; Cicer

Family

E2F/DP

Protein Properties

Length: 473aa MW: 51620 Da PI: 4.7659

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_004497676.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	83.3	2e-26	146	211	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++ll+++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn+i+wkg XP_004497676.1 146 RYDSSLGLLTKKFINLLKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKNIKNRIHWKG 211 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	2.6E-28	143	213	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	7.98E-17	146	209	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.9E-34	146	211	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	4.5E-24	148	211	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.28E-39	249	334	No hit	No description
Pfam	PF16421	4.6E-26	251	332	IPR032198	E2F transcription factor, CC-MB domain
SuperFamily	SSF144074	3.92E-25	252	334	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 473 aa Download sequence Send to blast
MSAGAGASDR GSPMPRESAG APIRPPLKRH LAFVSTKPPF APPDEYRSFA AVDARKVADH 60 VSEAVVVRSP LIKRKNGMNE SEGDSQKWSN SPGYSTVMNS PFKTPLSAKG GRASKSKVSK 120 EGRSCPPTPI SNAGSPSPLT PAGSCRYDSS LGLLTKKFIN LLKHAEDGIL DLNKAAETLE 180 VQKRRIYDIT NVLEGIGLIE KNIKNRIHWK GVESSTPGDV DGDISIIQGQ IQNFKVEARL 240 ADQAANDMRQ NVEMQERLRS LSEDENNQKF LFVTEEDIKG LPCFQNETLI AIKAPHGTTL 300 EVPDPEEAVD YLQRRYRIIL RSTMGPIDVY LISQFEEKFE EINGADPPTG FPLASSSGSN 360 EQLVTEMVPA ECSGKELEPQ ALLSSQAYSD LNASQEFAGG MMKIVPSDAD NDADYWLLSD 420 AEVSITDMWR TDSSVDWDGV DMLHPDFGMI SRPQTPSPGL AEAPSTVANP NLR

Sequence ? help Back to Top

Protein Sequence Length: 473 aa Download sequence Send to blast

MSAGAGASDR GSPMPRESAG APIRPPLKRH LAFVSTKPPF APPDEYRSFA AVDARKVADH  60
VSEAVVVRSP LIKRKNGMNE SEGDSQKWSN SPGYSTVMNS PFKTPLSAKG GRASKSKVSK  120
EGRSCPPTPI SNAGSPSPLT PAGSCRYDSS LGLLTKKFIN LLKHAEDGIL DLNKAAETLE  180
VQKRRIYDIT NVLEGIGLIE KNIKNRIHWK GVESSTPGDV DGDISIIQGQ IQNFKVEARL  240
ADQAANDMRQ NVEMQERLRS LSEDENNQKF LFVTEEDIKG LPCFQNETLI AIKAPHGTTL  300
EVPDPEEAVD YLQRRYRIIL RSTMGPIDVY LISQFEEKFE EINGADPPTG FPLASSSGSN  360
EQLVTEMVPA ECSGKELEPQ ALLSSQAYSD LNASQEFAGG MMKIVPSDAD NDADYWLLSD  420
AEVSITDMWR TDSSVDWDGV DMLHPDFGMI SRPQTPSPGL AEAPSTVANP NLR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-23	141	212	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_004497676.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	BT093046	2e-70	BT093046.1 Soybean clone JCVI-FLGm-15I8 unknown mRNA.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004497676.1	0.0	transcription factor E2FA
Swissprot	Q9FNY0	1e-160	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A1S2Y155	0.0	A0A1S2Y155_CICAR; transcription factor E2FA
STRING	XP_004497676.1	0.0	(Cicer arietinum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-155	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]