PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Bostr.12659s0396.1.p

Organism

Boechera stricta

Taxonomic ID

72658

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Boechereae; Boechera

Family

NAC

Protein Properties

Length: 456aa MW: 51274.8 Da PI: 4.5492

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Bostr.12659s0396.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	102.3	6.5e-32	58	192	1	128
NAM 1 lppGfrFhPtdeelvveyLkkk.vegkk....leleevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk. 79 lp+G++F+P+d+e++++ L+k+ ++g + ++ e+i++v+ i++++P++Lp vk++ + +fF+k+ k+y+tg+rk+r+++ Bostr.12659s0396.1.p 58 LPRGVKFDPSDSEIIWHLLAKSgLAGLSshpfID--EFIPTVNqddgICYTHPKNLP-GVKNDGTVSHFFHKAIKAYSTGTRKRRKIHd 143 799**********9999988544444543422..33444433345******.778888999**************8655 PP NAM 80 ....sgyWkatgkdkevlskkgelvglkktLvfykgrapkgektdWvmheyrl 128 + +W++tg++k+v+ +g + g+kk++v+y g+a kt+Wvmh+y+l Bostr.12659s0396.1.p 144 ddfgDVRWHKTGRTKPVVL-DGVQRGCKKIMVLYGGKAV---KTNWVMHQYHL 192 5655889********.99********76665...6******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.44E-37	43	211	IPR003441	NAC domain
PROSITE profile	PS51005	31.047	58	211	IPR003441	NAC domain
Pfam	PF02365	6.3E-13	59	192	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000077	Biological Process	DNA damage checkpoint
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010332	Biological Process	response to gamma radiation
GO:0040020	Biological Process	regulation of meiotic nuclear division
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 456 aa Download sequence Send to blast
MAGRSWLIDS NRIATKIMSA SASSDPRQVV WKSNPTRHCP NCRHVIDNSD VVDDWPGLPR 60 GVKFDPSDSE IIWHLLAKSG LAGLSSHPFI DEFIPTVNQD DGICYTHPKN LPGVKNDGTV 120 SHFFHKAIKA YSTGTRKRRK IHDDDFGDVR WHKTGRTKPV VLDGVQRGCK KIMVLYGGKA 180 VKTNWVMHQY HLGIEEDEKE GDYVVSKIFY QQPQQQVVKQ GDKAEQEVSE EIVAAMTPKV 240 DPVTPKLVTP EPRHAVRLCS DSHFANDYVI PHGYVTAQEV SLAETSEVMY MEDEVQSIQP 300 NHERPSSAYE PEPEPEPEPG LENGAKEMTD DKEEQEKDED DENQAEEEPT WFDSGSQFIL 360 NSQQLVEALS LCDDLLGSQD REENTNSGSF KNKQPCFADY AHLGTEDFKQ DLEECQKIVL 420 DPSNIELDTP PEFRLSQLEF GSQDSFLAWG TGKTD*

Sequence ? help Back to Top

Protein Sequence Length: 456 aa Download sequence Send to blast

MAGRSWLIDS NRIATKIMSA SASSDPRQVV WKSNPTRHCP NCRHVIDNSD VVDDWPGLPR  60
GVKFDPSDSE IIWHLLAKSG LAGLSSHPFI DEFIPTVNQD DGICYTHPKN LPGVKNDGTV  120
SHFFHKAIKA YSTGTRKRRK IHDDDFGDVR WHKTGRTKPV VLDGVQRGCK KIMVLYGGKA  180
VKTNWVMHQY HLGIEEDEKE GDYVVSKIFY QQPQQQVVKQ GDKAEQEVSE EIVAAMTPKV  240
DPVTPKLVTP EPRHAVRLCS DSHFANDYVI PHGYVTAQEV SLAETSEVMY MEDEVQSIQP  300
NHERPSSAYE PEPEPEPEPG LENGAKEMTD DKEEQEKDED DENQAEEEPT WFDSGSQFIL  360
NSQQLVEALS LCDDLLGSQD REENTNSGSF KNKQPCFADY AHLGTEDFKQ DLEECQKIVL  420
DPSNIELDTP PEFRLSQLEF GSQDSFLAWG TGKTD*

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Bostr.12659s0396.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK221266	0.0	AK221266.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL24-13-I20.
GenBank	AK228316	0.0	AK228316.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL14-74-M01.
GenBank	BT010450	0.0	BT010450.1 Arabidopsis thaliana At1g25580 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010477912.1	0.0	PREDICTED: NAC domain-containing protein 8
Swissprot	Q6NQK2	0.0	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A178WLI1	0.0	A0A178WLI1_ARATH; SOG1
STRING	Bostr.12659s0396.1.p	0.0	(Boechera stricta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM9707	27	36

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G25580.1	0.0	NAC family protein

Link Out ? help Back to Top
Phytozome	Bostr.12659s0396.1.p

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]