PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009149841.1
Organism
Brassica rapa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 578aa    MW: 66056.7 Da    PI: 10.3441
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009149841.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP757.9e-24220285171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     rk+ksL+ll+++fl+l+++   +++ l+++a++L    v  +rRRiYDi+NVLe++++++k++kn+++wkg
  XP_009149841.1 220 RKQKSLGLLCTNFLALYNRHGIETIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLTKRAKNQYTWKG 285
                     79*****************999************...**..****************************98 PP
2E2F_TDP794.4e-25352432171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL+lltq+f+kl+ +se++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  XP_009149841.1 352 RREKSLGLLTQNFIKLFVCSEARIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 432
                     689**************************************999************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.5E-26216287IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.72E-16219283IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-29220285IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.4E-21221285IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.105.2E-23350433IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-32352432IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.0E-20354432IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.43E-13354433IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 578 aa     Download sequence    Send to blast
MEEEKAAAYY DELTRKGEGA ARFKQGLGFS SGNDAVPERA SAIASSSSFL NQFVKASSNP  60
KPTENDSDIR SIRDKLKKEK NKPEDQHSEK SSSDRRRYRS RERDERDRRR SRSAERRSGY  120
GDRERRRRRS RSRSSSPRRE RRRREDDRRG RRTQKRTKFK LALKFSSFNV SSPQFISNLF  180
SLNPSLPILL SVPTMSDLPP ENPNLPLTSS SSSLHHSYSR KQKSLGLLCT NFLALYNRHG  240
IETIGLDDAA SKLGVERRRI YDIVNVLESV GVLTKRAKNQ YTWKGFSAIP AALKELQEEG  300
AKDTFHRFYT NENVKVSDDE DDEEESSSQP LSSSQTDTSK PGSLDPSKID NRREKSLGLL  360
TQNFIKLFVC SEARIISLDE AAKLLLGDAH NTSIMRTKVR RLYDIANVLS SMNLIEKTHT  420
LDSRKPAFKW LGYNGEPTFT LSSDLMQAES TKRVFGTDLT NVSVKRSRTH ENATERRIKM  480
KQHAIADSSY NQSSDDAHES RRYKFGLFAP AAGGTYPAAR LEDNSKRAFD VENLVSDYRP  540
TYQNQVLKDL FAHYMDAWKS WYSEVTQKNP LPDTSKRH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-392194243228Transcription factor E2F8
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1122132RERRRRRSRSR
2126143RRRSRSRSSSPRRERRRR
3137144RRERRRRE
4139144ERRRRE
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Bra.273620.0root
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_009149841.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3531970.0AK353197.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-26-N13.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018515445.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLM4DNJ30.0M4DNJ3_BRARP; Uncharacterized protein
STRINGBra018080.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]