PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_013625114.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 471aa    MW: 51556.4 Da    PI: 4.506
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_013625114.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP794.2e-25157222171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt++f++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe++ liek  kn+i wkg
  XP_013625114.1 157 RYDSSLGLLTKRFVNLIKQAEDGMLDLNKAAEAL---EV--QKRRIYDITNVLEGIYLIEKPFKNRILWKG 222
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.5E-27153224IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.63E-15157220IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.8E-31157222IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.0E-21159222IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440749.68E-33235339No hitNo description
CDDcd146601.09E-48235339No hitNo description
PfamPF164214.3E-33238337IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 471 aa     Download sequence    Send to blast
MSGGVRSSPG HSQPPPSNPV VPPIRRHLAF ASTKPPFHPS DYRRFIPSYV TNNDSSSLCG  60
IVDREEEAVV LRSPSRKRKS MMDVVTTTTT TTSNSNGFTS SGSTSIHNSP CLTPVSAKGG  120
RVNTKSRAKG TQSVPQTPIS NAVVGSPATL TPSGSCRYDS SLGLLTKRFV NLIKQAEDGM  180
LDLNKAAEAL EVQKRRIYDI TNVLEGIYLI EKPFKNRILW KGVDASRPGD VDADVSVLQA  240
EIENLNLQEQ ALDNQIRETE ERLRDLSENE KNQKWLFVTE EDIKSLPGFQ NQTLIAVKAP  300
HGTTLEVPDP DEAGELPQRR YRIILRSTMG PIDVYLVSEF EDTNGDVAPP ACLHIASCSG  360
STENNEIEAL TIDNTETASE LQMSQDHAHA QPGDTSDLNY LQEQVGGMLK ITPSDIENDD  420
TDYWLLSNAE ISMTDIWNTD SGIDWDYGIA DVTPPPVMSE IASADIDSKP T
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-21152223274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
17479SRKRKS
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_013625114.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013625114.10.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A0D3B5630.0A0A0D3B563_BRAOL; Uncharacterized protein
STRINGBo3g029900.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]