PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Bradi3g45130.2.p
Common NameBRADI_3g45130, LOC100823596
Organism
Brachypodium distachyon
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Brachypodieae; Brachypodium
Family E2F/DP
Protein Properties Length: 472aa    MW: 51270.2 Da    PI: 4.7449
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Bradi3g45130.2.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.67.7e-27152217171
           E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                       r+++sL+llt+kf++ll+++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  Bradi3g45130.2.p 152 RYDSSLGLLTKKFITLLKQADDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 217
                       6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.9E-28150219IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.01E-17152215IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.0E-34152217IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.8E-24154217IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146608.64E-49227333No hitNo description
SuperFamilySSF1440746.54E-34230333No hitNo description
PfamPF164213.0E-33232331IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 472 aa     Download sequence    Send to blast
MSGGGRPPAA QKILQSLRPP PVFSAPARPP FASPDDYHRF PAPTPSSATG SGSGGIGAGG  60
VGADIEEGLI IRTPSPLVQL KRKAAREEND ASESSDCMII SPGFTGNKLL TPVSGKAVKT  120
SKSKAKNNKA GPQTPTQNVG SPLNPATPGT CRYDSSLGLL TKKFITLLKQ ADDGILDLNN  180
AAETLEVQKR RIYDITNVLE GIGLIEKTLK NRIRWKGLDD SGVELDNGLS ALQAEVEDLN  240
LQEQALDERI SDMREKLRGL TEDENSQRWL YVTEDDIKGL PCFQNETLIA IKAPHGTTLE  300
VPDPDEAGDY LQRRYRIVLR STMGPIDVYL VSQFDEGFED LGGAATPPRH TNVPTHRPPE  360
DLHTTNAAQS SKSMDVEHNI QYSQNTPHDP SSAHDFGGMT RIIPSDVNTD ADYWLLTEGD  420
VSITDIWKTA PEVQWDSDVF LPEDVSTPRA HNQHPVAVGE SRMQVQSMDQ P*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-24145218274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapBradi3g45130.2.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ2385900.0AJ238590.1 Triticum sp. mRNA for E2F protein.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_014755531.10.0transcription factor E2FA isoform X1
SwissprotQ9FNY01e-127E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A0Q3JN440.0A0A0Q3JN44_BRADI; Uncharacterized protein
STRINGBRADI3G45130.10.0(Brachypodium distachyon)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-117E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]