PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT5G53950.1

Common Name

ANAC098, ATCUC2, CUC2, K19P17.12, NAC098

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

NAC

Protein Properties

Length: 375aa MW: 41434.3 Da PI: 8.5221

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT5G53950.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	177.5	3.6e-55	17	145	1	129
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlsk.kg 97 lppGfrFhPtdeel+++yL +kv + ++ ++i+evd++k+ePw+Lp ++k +ekewyfFs rd+ky+tg r+nrat++gyWkatgkd+e++s+ + AT5G53950.1 17 LPPGFRFHPTDEELITHYLLRKVLDGCFSS-RAIAEVDLNKCEPWQLPGRAKMGEKEWYFFSLRDRKYPTGLRTNRATEAGYWKATGKDREIFSSkTC 113 79***********************999.89***********99999************************************97455 PP NAM 98 elvglkktLvfykgrapkgektdWvmheyrle 129 +lvg+kktLvfykgrapkgek++Wvmheyrle AT5G53950.1 114 ALVGMKKTLVFYKGRAPKGEKSNWVMHEYRLE 145 67**************************85 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	4.45E-63	4	169	IPR003441	NAC domain
PROSITE profile	PS51005	59.639	17	169	IPR003441	NAC domain
Pfam	PF02365	5.1E-29	18	144	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010072	Biological Process	primary shoot apical meristem specification
GO:0010160	Biological Process	formation of organ boundary
GO:0010223	Biological Process	secondary shoot formation
GO:0048366	Biological Process	leaf development
GO:0048504	Biological Process	regulation of timing of organ formation
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000037	anatomy	shoot apex
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009052	anatomy	flower pedicel
PO:0020100	anatomy	hypocotyl
PO:0020144	anatomy	apical meristem
PO:0025022	anatomy	collective leaf structure
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 375 aa Download sequence Send to blast
MDIPYYHYDH GGDSQYLPPG FRFHPTDEEL ITHYLLRKVL DGCFSSRAIA EVDLNKCEPW 60 QLPGRAKMGE KEWYFFSLRD RKYPTGLRTN RATEAGYWKA TGKDREIFSS KTCALVGMKK 120 TLVFYKGRAP KGEKSNWVMH EYRLEGKFSY HFISRSSKDE WVISRVFQKT TLASTGAVSE 180 GGGGGGATVS VSSGTGPSKK TKVPSTISRN YQEQPSSPSS VSLPPLLDPT TTLGYTDSSC 240 SYDSRSTNTT VTASAITEHV SCFSTVPTTT TALGLDVNSF SRLPPPLGFD FDPFPRFVSR 300 NVSTQSNFRS FQENFNQFPY FGSSSASTMT SAVNLPSFQG GGGVSGMNYW LPATAEENES 360 KVGVLHAGLD CIWNY

Sequence ? help Back to Top

Protein Sequence Length: 375 aa Download sequence Send to blast

MDIPYYHYDH GGDSQYLPPG FRFHPTDEEL ITHYLLRKVL DGCFSSRAIA EVDLNKCEPW  60
QLPGRAKMGE KEWYFFSLRD RKYPTGLRTN RATEAGYWKA TGKDREIFSS KTCALVGMKK  120
TLVFYKGRAP KGEKSNWVMH EYRLEGKFSY HFISRSSKDE WVISRVFQKT TLASTGAVSE  180
GGGGGGATVS VSSGTGPSKK TKVPSTISRN YQEQPSSPSS VSLPPLLDPT TTLGYTDSSC  240
SYDSRSTNTT VTASAITEHV SCFSTVPTTT TALGLDVNSF SRLPPPLGFD FDPFPRFVSR  300
NVSTQSNFRS FQENFNQFPY FGSSSASTMT SAVNLPSFQG GGGVSGMNYW LPATAEENES  360
KVGVLHAGLD CIWNY

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ut4_A	6e-52	17	174	17	170	NO APICAL MERISTEM PROTEIN
1ut4_B	6e-52	17	174	17	170	NO APICAL MERISTEM PROTEIN
1ut7_A	6e-52	17	174	17	170	NO APICAL MERISTEM PROTEIN
1ut7_B	6e-52	17	174	17	170	NO APICAL MERISTEM PROTEIN
3swm_A	6e-52	17	174	20	173	NAC domain-containing protein 19
3swm_B	6e-52	17	174	20	173	NAC domain-containing protein 19
3swm_C	6e-52	17	174	20	173	NAC domain-containing protein 19
3swm_D	6e-52	17	174	20	173	NAC domain-containing protein 19
3swp_A	6e-52	17	174	20	173	NAC domain-containing protein 19
3swp_B	6e-52	17	174	20	173	NAC domain-containing protein 19
3swp_C	6e-52	17	174	20	173	NAC domain-containing protein 19
3swp_D	6e-52	17	174	20	173	NAC domain-containing protein 19
4dul_A	6e-52	17	174	17	170	NAC domain-containing protein 19
4dul_B	6e-52	17	174	17	170	NAC domain-containing protein 19
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.55538	0.0	flower

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	145359221	0.0
Genevisible	248240_at	0.0
Expression Atlas	AT5G53950	-
AtGenExpress	AT5G53950	-
ATTED-II	AT5G53950	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: First expressed in early to mid-globular-stage embryos. In late globular stage, detected as a stripe running medially across the top of the embryo. In heart stage embryo, expression is restricted to a stripe between the cotyledon primordia, but confined to hypodermal cells. In the bending-cotyledon stage, localized in a region surrounding the SAM, that correspond to the boundary region of cotyledon margins (BCM) and the boundaries between SAM and cotyledons, including protoderm cells. Observed in the margins of leaf primordia, and later restricted to the leaf sinus region, with a diminution in outgrowing teeth. Restricted to the proximal part of mature leaves. Expressed at the boundaries between the inflorescence meristem (IM) and flower primordia. Once the flower starts to grow out and the internode begin to elongates, restricted to the axils of the floral pedicels through several nodes. Detected within floral primordia, between sepal primordia and the floral meristem. Also present at the boundaries of individual sepal primordia, as well as in the region surrounding each petal and stamen primordium. Later detected transiently at the boundaries between locules of each theca in anthers. Expression at the inner part of presumtive septal regions that raises to include presumptive placenta, at the tips of septal primordia, as septum grow. Localized in the fused region of the septum. Found at the boundaries of ovule primordia, and later at the boundary between the nucellus and the chalaza. {ECO:0000269\|PubMed:10079219, ECO:0000269\|PubMed:10750709, ECO:0000269\|PubMed:17098808, ECO:0000269\|PubMed:17251269}.
Uniprot	TISSUE SPECIFICITY: Mostly expressed in buds and flowers, and, to a lower extent, in the aerial parts of seedling, inflorescence and old silique. In a general manner, present at the boundaries between mersitems and araising primordia. {ECO:0000269\|PubMed:10750709, ECO:0000269\|PubMed:15053771, ECO:0000269\|PubMed:9212461}.

Functional Description ? help Back to Top
Source	Description
TAIR	Transcriptional activator of the NAC gene family, with CUC1 redundantly required for embryonic apical meristem formation, cotyledon separation and expression of STM. Proper timing of CUC2 expression is required to maintain the phyllotactic pattern initiated in the meristem. CUC2 expression in leaf sinus region is required for serration and the extent of serration is modulated by mir164A mediated repression of CUC2.
UniProt	Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of cell division. {ECO:0000269\|PubMed:10079219, ECO:0000269\|PubMed:10750709, ECO:0000269\|PubMed:12163400, ECO:0000269\|PubMed:12492830, ECO:0000269\|PubMed:12610213, ECO:0000269\|PubMed:15202996, ECO:0000269\|PubMed:15294871, ECO:0000269\|PubMed:15500463, ECO:0000269\|PubMed:15723790, ECO:0000269\|PubMed:16798887, ECO:0000269\|PubMed:17098808, ECO:0000269\|PubMed:17122068, ECO:0000269\|PubMed:17251269, ECO:0000269\|PubMed:17287247, ECO:0000269\|PubMed:9212461}.

Function -- GeneRIF ? help Back to Top
The molecular basis for the activity of the protein. [PMID: 15500463] The balance between coexpressed CUC2 and MIR164A then determines the extent of serration. [PMID: 17098808] We show here that plants expressing a miR164-resistant CUP-SHAPED COTYLEDON2 (CUC2) gene have an abnormal phyllotactic pattern in the fully grown stem, despite the pattern of organ initiation by the meristem being normal. [PMID: 17251269] Regulation of axillary meristem formation by miR164 is mediated through CUC1 and CUC2, which in turn regulate LAS. [PMID: 18346190] miRNA164 and CUC2 form a central regulatory module that acts as a governor of lateral organ patterning and expansion. [PMID: 19154203] CUC2 and CUC3 expression mediated by AHK2 and AHK3 signaling may play roles in regulation of flower development. [PMID: 19913077] CUC2 promotes outgrowth of leaf teeth via cell division. [PMID: 20128880] CUC2 and CUC3 are expressed in leaf primordia and are required for wild-type serration. CUC1 and CUC2 resulted from duplications of a unique ancestral gene and show different patterns of evolution. [PMID: 21258003] CUC2 is a predictive marker for the acquisition of root explant competence for root and shoot organogenesis. [PMID: 21507507] SPT negatively regulates CUC1 and CUC2 expression in the apical part of the gynoecium. [PMID: 22514090] DPA4 expression domains overlap with those of the known leaf shape regulator CUP-SHAPED COTYLEDON 2 (CUC2) and we provide evidence that DPA4 negatively regulates CUC2 expression independently of MIR164A, an established regulator of CUC2 [PMID: 22675210] Cup-shaped cotyledon (CUC)1, CUC2, and AINTEGUMENTA (ANT) have additive effects on ovule primordia formation. [PMID: 23941199] The cuc2 cuc3 double mutant displays irregular phyllotaxis in the mature shoot but not in the shoot apex, thus showing a post-meristematic effect of the mutations on phyllotaxis. [PMID: 25681504] cuc1 grf1/2/3, cuc2 grf1/2/3, and cuc3 grf1/2/3 quadruple mutants showed dramatic increases in cotyledon fusion as well as floral organ fusion. [PMID: 25761011] PLT3, PLT5, and PLT7 additionally regulate and require the shoot-promoting factor CUP-SHAPED COTYLEDON2 (CUC2) to complete the shoot-formation program. [PMID: 25819565] Genetic analysis established that SVR9/SVR9-LIKE1 (SVR9L1)-mediated leaf margin development is dependent on CUP-SHAPED COTYLEDON2 (CUC2) activities and is independent of their roles in chloroplast development. [PMID: 27535792] we show that CUC2 acts as a trigger to promote growth through the activation of three functional relays. In particular, we show that KLUH acts downstream of CUC2 to modulate auxin response and that expressing KLUH can compensate for deficient CUC2 expression during tooth growth. [PMID: 30677017]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00562	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT5G53950.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By BRM and SYD, at the chromatin level, and conferring a very specific spatial expression pattern. Precise spatial regulation by post-transcriptional repression directed by the microRNA miR164. {ECO:0000269\|PubMed:15202996, ECO:0000269\|PubMed:15294871, ECO:0000269\|PubMed:15723790, ECO:0000269\|PubMed:16854978, ECO:0000269\|PubMed:17251269, ECO:0000269\|PubMed:17287247}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G65620 (R), AT2G36890 (A), AT2G37630 (R), AT5G23000 (A)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT1G23380(A), AT1G55580(A), AT1G62360(A), AT1G76420(A), AT2G31160(A), AT3G23290(A)

Regulation -- MicroRNA ? help Back to Top
Source	Description
miRTarBase	Regulated by ath-miR164b, ath-miR164a

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	Cytokinin

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G14920
IntAct	Search O04017

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT5G53950

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	BT030026	0.0	BT030026.1 Arabidopsis thaliana At5g53950 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_200206.1	0.0	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein
Swissprot	O04017	0.0	NAC98_ARATH; Protein CUP-SHAPED COTYLEDON 2
TrEMBL	A0A178UAW2	0.0	A0A178UAW2_ARATH; CUC2
STRING	AT5G53950.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6615	27	45
Representative plant	OGRP17	15	800

Link Out ? help Back to Top
Phytozome	AT5G53950.1
Entrez Gene	835478
iHOP	AT5G53950
wikigenes	AT5G53950

Publications ? help Back to Top
Aida M,Ishida T,Tasaka M Shoot apical meristem and cotyledon formation during Arabidopsis embryogenesis: interaction among the CUP-SHAPED COTYLEDON and SHOOT MERISTEMLESS genes. Development, 1999. 126(8): p. 1563-70 [PMID:10079219] Kikuchi K, et al. Molecular analysis of the NAC gene family in rice. Mol. Gen. Genet., 2000. 262(6): p. 1047-51 [PMID:10660065] Ishida T,Aida M,Takada S,Tasaka M Involvement of CUP-SHAPED COTYLEDON genes in gynoecium and ovule development in Arabidopsis thaliana. Plant Cell Physiol., 2000. 41(1): p. 60-7 [PMID:10750709] Vernoux T,Kronenberger J,Grandjean O,Laufs P,Traas J PIN-FORMED 1 regulates cell fate at the periphery of the shoot apical meristem. Development, 2000. 127(23): p. 5157-65 [PMID:11060241] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Takada S,Hibara K,Ishida T,Tasaka M The CUP-SHAPED COTYLEDON1 gene of Arabidopsis regulates shoot apical meristem formation. Development, 2001. 128(7): p. 1127-35 [PMID:11245578] Aida M,Vernoux T,Furutani M,Traas J,Tasaka M Roles of PIN-FORMED1 and MONOPTEROS in pattern formation of the apical region of the Arabidopsis embryo. Development, 2002. 129(17): p. 3965-74 [PMID:12163400] Duval M,Hsieh TF,Kim SY,Thomas TL Molecular characterization of AtNAM: a member of the Arabidopsis NAC domain superfamily. Plant Mol. Biol., 2002. 50(2): p. 237-48 [PMID:12175016] Cary AJ,Che P,Howell SH Developmental events and shoot apical meristem gene expression patterns during shoot development in Arabidopsis thaliana. Plant J., 2002. 32(6): p. 867-77 [PMID:12492830] Daimon Y,Takabe K,Tasaka M The CUP-SHAPED COTYLEDON genes promote adventitious shoot formation on calli. Plant Cell Physiol., 2003. 44(2): p. 113-21 [PMID:12610213] Greve K,La Cour T,Jensen MK,Poulsen FM,Skriver K Interactions between plant RING-H2 and plant-specific NAC (NAM/ATAF1/2/CUC2) proteins: RING-H2 molecular specificity and cellular localization. Biochem. J., 2003. 371(Pt 1): p. 97-108 [PMID:12646039] Vroemen CW,Mordhorst AP,Albrecht C,Kwaaitaal MA,de Vries SC The CUP-SHAPED COTYLEDON3 gene is required for boundary and shoot meristem formation in Arabidopsis. Plant Cell, 2003. 15(7): p. 1563-77 [PMID:12837947] Hibara K,Takada S,Tasaka M CUC1 gene activates the expression of SAM-related genes to induce adventitious shoot formation. Plant J., 2003. 36(5): p. 687-96 [PMID:14617069] Ooka H, et al. Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana. DNA Res., 2003. 10(6): p. 239-47 [PMID:15029955] Breuil-Broyer S, et al. High-resolution boundary analysis during Arabidopsis thaliana flower development. Plant J., 2004. 38(1): p. 182-92 [PMID:15053771] Mallory AC,Dugas DV,Bartel DP,Bartel B MicroRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic, vegetative, and floral organs. Curr. Biol., 2004. 14(12): p. 1035-46 [PMID:15202996] Laufs P,Peaucelle A,Morin H,Traas J MicroRNA regulation of the CUC genes is required for boundary size control in Arabidopsis meristems. Development, 2004. 131(17): p. 4311-22 [PMID:15294871] Furutani M, et al. PIN-FORMED1 and PINOID regulate boundary formation and cotyledon development in Arabidopsis embryogenesis. Development, 2004. 131(20): p. 5021-30 [PMID:15371311] Taoka K, et al. The NAC domain mediates functional specificity of CUP-SHAPED COTYLEDON proteins. Plant J., 2004. 40(4): p. 462-73 [PMID:15500463] Baker CC,Sieber P,Wellmer F,Meyerowitz EM The early extra petals1 mutant uncovers a role for microRNA miR164c in regulating petal number in Arabidopsis. Curr. Biol., 2005. 15(4): p. 303-15 [PMID:15723790] Kidner CA,Martienssen RA The role of ARGONAUTE1 (AGO1) in meristem formation and identity. Dev. Biol., 2005. 280(2): p. 504-17 [PMID:15882589] Yanai O, et al. Arabidopsis KNOXI proteins activate cytokinin biosynthesis. Curr. Biol., 2005. 15(17): p. 1566-71 [PMID:16139212] Zimmermann R,Werr W Pattern formation in the monocot embryo as revealed by NAM and CUC3 orthologues from Zea mays L. Plant Mol. Biol., 2005. 58(5): p. 669-85 [PMID:16158242] Keller T,Abbott J,Moritz T,Doerner P Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development. Plant Cell, 2006. 18(3): p. 598-611 [PMID:16473968] Belles-Boix E, et al. KNAT6: an Arabidopsis homeobox gene involved in meristem activity and organ separation. Plant Cell, 2006. 18(8): p. 1900-7 [PMID:16798887] Kwon CS, et al. A role for chromatin remodeling in regulation of CUC gene expression in the Arabidopsis cotyledon boundary. Development, 2006. 133(16): p. 3223-30 [PMID:16854978] Nikovics K, et al. The balance between the MIR164A and CUC2 genes controls leaf margin serration in Arabidopsis. Plant Cell, 2006. 18(11): p. 2929-45 [PMID:17098808] Kim YS, et al. A membrane-bound NAC transcription factor regulates cell division in Arabidopsis. Plant Cell, 2006. 18(11): p. 3132-44 [PMID:17098812] Zhong R,Demura T,Ye ZH SND1, a NAC domain transcription factor, is a key regulator of secondary wall synthesis in fibers of Arabidopsis. Plant Cell, 2006. 18(11): p. 3158-70 [PMID:17114348] Hibara K, et al. Arabidopsis CUP-SHAPED COTYLEDON3 regulates postembryonic shoot meristem and organ boundary formation. Plant Cell, 2006. 18(11): p. 2946-57 [PMID:17122068] Zluvova J,Nicolas M,Berger A,Negrutiu I,Mon Premature arrest of the male flower meristem precedes sexual dimorphism in the dioecious plant Silene latifolia. Proc. Natl. Acad. Sci. U.S.A., 2006. 103(49): p. 18854-9 [PMID:17132741] Peaucelle A,Morin H,Traas J,Laufs P Plants expressing a miR164-resistant CUC2 gene reveal the importance of post-meristematic maintenance of phyllotaxy in Arabidopsis. Development, 2007. 134(6): p. 1045-50 [PMID:17251269] Sieber P,Wellmer F,Gheyselinck J,Riechmann JL,Meyerowitz EM Redundancy and specialization among plant microRNAs: role of the MIR164 family in developmental robustness. Development, 2007. 134(6): p. 1051-60 [PMID:17287247] Gordon SP, et al. Pattern formation during de novo assembly of the Arabidopsis shoot meristem. Development, 2007. 134(19): p. 3539-48 [PMID:17827180] Xu B, et al. Arabidopsis genes AS1, AS2, and JAG negatively regulate boundary-specifying genes to promote sepal and petal development. Plant Physiol., 2008. 146(2): p. 566-75 [PMID:18156293] Raman S, et al. Interplay of miR164, CUP-SHAPED COTYLEDON genes and LATERAL SUPPRESSOR controls axillary meristem formation in Arabidopsis thaliana. Plant J., 2008. 55(1): p. 65-76 [PMID:18346190] Dortay H, et al. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. J. Proteome Res., 2008. 7(9): p. 3649-60 [PMID:18642946] Tamaki H, et al. Identification of novel meristem factors involved in shoot regeneration through the analysis of temperature-sensitive mutants of Arabidopsis. Plant J., 2009. 57(6): p. 1027-39 [PMID:19054368] Larue CT,Wen J,Walker JC A microRNA-transcription factor module regulates lateral organ size and patterning in Arabidopsis. Plant J., 2009. 58(3): p. 450-63 [PMID:19154203] Koizumi A,Yamanaka K,Kawano S Carpel development in a floral mutant of dioecious Silene latifolia producing asexual and female-like flowers. J. Plant Physiol., 2009. 166(16): p. 1832-8 [PMID:19457581] Lee DK,Geisler M,Springer PS LATERAL ORGAN FUSION1 and LATERAL ORGAN FUSION2 function in lateral organ separation and axillary meristem formation in Arabidopsis. Development, 2009. 136(14): p. 2423-32 [PMID:19542355] Kim SG,Park CM Membrane-mediated salt stress signaling in flowering time control. Plant Signal Behav, 2007. 2(6): p. 517-8 [PMID:19704545] Peaucelle A,Laufs P Phyllotaxy: Beyond the Meristem and Auxin Comes the miRNA. Plant Signal Behav, 2007. 2(4): p. 293-5 [PMID:19704686] Mon Sex determination in plants. Plant Signal Behav, 2007. 2(3): p. 178-9 [PMID:19704689] Li XG, et al. Cytokinin overproduction-caused alteration of flower development is partially mediated by CUC2 and CUC3 in Arabidopsis. Gene, 2010. 450(1-2): p. 109-20 [PMID:19913077] Koizumi A, et al. Two separate pathways including SlCLV1, SlSTM and SlCUC that control carpel development in a bisexual mutant of Silene latifolia. Plant Cell Physiol., 2010. 51(2): p. 282-93 [PMID:20064843] Kawamura E,Horiguchi G,Tsukaya H Mechanisms of leaf tooth formation in Arabidopsis. Plant J., 2010. 62(3): p. 429-41 [PMID:20128880] Yamaguchi M, et al. VND-INTERACTING2, a NAC domain transcription factor, negatively regulates xylem vessel formation in Arabidopsis. Plant Cell, 2010. 22(4): p. 1249-63 [PMID:20388856] Yabuta Y, et al. Identification of recognition sequence of ANAC078 protein by the cyclic amplification and selection of targets technique. Plant Signal Behav, 2010. 5(6): p. 695-7 [PMID:20404498] Wang H, et al. Mutation of WRKY transcription factors initiates pith secondary wall formation and increases stem biomass in dicotyledonous plants. Proc. Natl. Acad. Sci. U.S.A., 2010. 107(51): p. 22338-43 [PMID:21135241] Szakonyi D,Byrne ME Ribosomal protein L27a is required for growth and patterning in Arabidopsis thaliana. Plant J., 2011. 65(2): p. 269-81 [PMID:21223391] Hasson A, et al. Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development. Plant Cell, 2011. 23(1): p. 54-68 [PMID:21258003] Bilsborough GD, et al. Model for the regulation of Arabidopsis thaliana leaf margin development. 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