PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT5G41410.1

Common Name

BEL1, BELL1, MYC6.12

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

TALE

Protein Properties

Length: 611aa MW: 69493.2 Da PI: 6.9725

Description

TALE family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT5G41410.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	27.2	6.8e-09	411	448	19	54
HHH..SSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHH CS Homeobox 19 Fek..nrypsaeereeLAkklgLterqVkvWFqNrRak 54 Fe ++yps ++ LA+++gL+ +qV++WF N R + AT5G41410.1 411 FEHflHPYPSDVDKHILARQTGLSRSQVSNWFINARVR 448 554459******************************88 PP
2	BELL	106.2	2.2e-34	269	340	1	72
BELL 1 erqelqkkkakLlslleeVdkrYkqyveqlqtvissFeavaglgsakpYtslAlkaiSrhFrcLkdaiaeqi 72 e++elqk+kakLls+lee+++rY +y+eq+++ +++Fea++glg a++Yt+lA++a+SrhFrcLkd +++qi AT5G41410.1 269 EFMELQKRKAKLLSMLEELKRRYGHYREQMRVAAAAFEAAVGLGGAEIYTALASRAMSRHFRCLKDGLVGQI 340 679*******************************************************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF07526	1.7E-42	194	336	IPR006563	POX domain
SMART	SM00574	1.1E-71	200	338	IPR006563	POX domain
PROSITE profile	PS50071	12.017	389	452	IPR001356	Homeobox domain
SMART	SM00389	5.6E-9	392	456	IPR001356	Homeobox domain
CDD	cd00086	9.21E-11	392	453	No hit	No description
SuperFamily	SSF46689	3.38E-17	393	460	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	7.7E-28	395	459	IPR009057	Homeodomain-like
Pfam	PF05920	8.1E-18	409	448	IPR008422	Homeobox KN domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0048481	Biological Process	plant ovule development
GO:0005634	Cellular Component	nucleus
GO:0005829	Cellular Component	cytosol
GO:0009506	Cellular Component	plasmodesma
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0005515	Molecular Function	protein binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000018	anatomy	ovule primordium
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020003	anatomy	plant ovule
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 611 aa Download sequence Send to blast
MARDQFYGHN NHHHQEQQHQ MINQIQGFDE TNQNPTDHHH YNHQIFGSNS NMGMMIDFSK 60 QQQIRMTSGS DHHHHHHQTS GGTDQNQLLE DSSSAMRLCN VNNDFPSEVN DERPPQRPSQ 120 GLSLSLSSSN PTSISLQSFE LRPQQQQQQG YSGNKSTQHQ NLQHTQMMMM MMNSHHQNNN 180 NNNHQHHNHH QFQIGSSKYL SPAQELLSEF CSLGVKESDE EVMMMKHKKK QKGKQQEEWD 240 TSHHSNNDQH DQSATTSSKK HVPPLHSLEF MELQKRKAKL LSMLEELKRR YGHYREQMRV 300 AAAAFEAAVG LGGAEIYTAL ASRAMSRHFR CLKDGLVGQI QATSQALGER EEDNRAVSIA 360 ARGETPRLRL LDQALRQQKS YRQMTLVDAH PWRPQRGLPE RAVTTLRAWL FEHFLHPYPS 420 DVDKHILARQ TGLSRSQVSN WFINARVRLW KPMIEEMYCE ETRSEQMEIT NPMMIDTKPD 480 PDQLIRVEPE SLSSIVTNPT SKSGHNSTHG TMSLGSTFDF SLYGNQAVTY AGEGGPRGDV 540 SLTLGLQRND GNGGVSLALS PVTAQGGQLF YGRDHIEEGP VQYSASMLDD DQVQNLPYRN 600 LMGAQLLHDI V

Sequence ? help Back to Top

Protein Sequence Length: 611 aa Download sequence Send to blast

MARDQFYGHN NHHHQEQQHQ MINQIQGFDE TNQNPTDHHH YNHQIFGSNS NMGMMIDFSK  60
QQQIRMTSGS DHHHHHHQTS GGTDQNQLLE DSSSAMRLCN VNNDFPSEVN DERPPQRPSQ  120
GLSLSLSSSN PTSISLQSFE LRPQQQQQQG YSGNKSTQHQ NLQHTQMMMM MMNSHHQNNN  180
NNNHQHHNHH QFQIGSSKYL SPAQELLSEF CSLGVKESDE EVMMMKHKKK QKGKQQEEWD  240
TSHHSNNDQH DQSATTSSKK HVPPLHSLEF MELQKRKAKL LSMLEELKRR YGHYREQMRV  300
AAAAFEAAVG LGGAEIYTAL ASRAMSRHFR CLKDGLVGQI QATSQALGER EEDNRAVSIA  360
ARGETPRLRL LDQALRQQKS YRQMTLVDAH PWRPQRGLPE RAVTTLRAWL FEHFLHPYPS  420
DVDKHILARQ TGLSRSQVSN WFINARVRLW KPMIEEMYCE ETRSEQMEIT NPMMIDTKPD  480
PDQLIRVEPE SLSSIVTNPT SKSGHNSTHG TMSLGSTFDF SLYGNQAVTY AGEGGPRGDV  540
SLTLGLQRND GNGGVSLALS PVTAQGGQLF YGRDHIEEGP VQYSASMLDD DQVQNLPYRN  600
LMGAQLLHDI V

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3k2a_A	3e-15	398	456	5	63	Homeobox protein Meis2
3k2a_B	3e-15	398	456	5	63	Homeobox protein Meis2
4xrm_A	3e-15	398	456	5	63	Homeobox protein Meis2
4xrm_B	3e-15	398	456	5	63	Homeobox protein Meis2
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.24568	0.0	flower\| seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30693794	0.0
Genevisible	249309_at	0.0
Expression Atlas	AT5G41410	-
AtGenExpress	AT5G41410	-
ATTED-II	AT5G41410	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Early expression is detected in the inflorescence apex of developing flowers and also in the ovule primordium and the integuments. {ECO:0000269\|PubMed:8521490}.
Uniprot	TISSUE SPECIFICITY: Expressed in both floral and vegetative tissues. {ECO:0000269\|PubMed:8521490}.

Functional Description ? help Back to Top
Source	Description
TAIR	Homeodomain protein required for ovule identity.Loss of function mutations show homeotic conversion of integuments to carpels.Forms heterodimers with STM and KNAT1. Interacts with AG-SEP heterodimers is thought to restrict WUS expression. BEL interacts with MADS box dimers composed of SEP1(or SEP3) and AG, SHP1, SHP2 and STK. The interaction of BEL1 with AG-SEP3 is required for proper integument development and specification of integument identity.
UniProt	Plays a major role in ovule patterning and in determination of integument identity via its interaction with MADS-box factors. Formation of complex with AG-SEP dimers negatively regulates the carpel identity process and favors the maintenance of ovule identity. BEL1-STM complex maintains the indeterminacy of the inflorescence meristem. Required, with SPL, for cytokinin-induced PIN1 expression in ovules (PubMed:22786869). {ECO:0000269\|PubMed:12244239, ECO:0000269\|PubMed:17693535, ECO:0000269\|PubMed:22786869}.

Function -- GeneRIF ? help Back to Top
BEL1 interacts with the ovule identity MADS box factors when they dimerize with SEPALLATA proteins. [PMID: 17693535] The transcription factors BEL1 and SPL/NZZ, previously described as key regulators of ovule development, are needed for the auxin and cytokinin signaling pathways for the correct patterning of the ovule. [PMID: 22786869] The branching ovules of the mutant resemble those of some fossil gymnosperms, implicating BEL1 and HD-ZIPIII genes as players in the evolution of the unbranched ovule form in extant angiosperms. [PMID: 26700684]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT5G41410.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT1G23420(A), AT2G17950(R), AT4G18960(R)

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G23380, AT1G24260, AT1G26260, AT1G62360, AT1G70510, AT1G75410
IntAct	Search Q38897

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT5G41410

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	ATU39944	0.0	U39944.2 Arabidopsis thaliana homeobox protein (BEL1) mRNA, complete cds.
GenBank	AY049237	0.0	AY049237.1 Arabidopsis thaliana AT5g41410/MYC6_12 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_198957.1	0.0	POX (plant homeobox) family protein
Swissprot	Q38897	0.0	BEL1_ARATH; Homeobox protein BEL1 homolog
TrEMBL	A0A178U8G7	0.0	A0A178U8G7_ARATH; BEL1
STRING	AT5G41410.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM5866	26	39
Representative plant	OGRP133	16	172

Link Out ? help Back to Top
Phytozome	AT5G41410.1
Entrez Gene	834143
iHOP	AT5G41410
wikigenes	AT5G41410

Publications ? help Back to Top
Western TL,Haughn GW BELL1 and AGAMOUS genes promote ovule identity in Arabidopsis thaliana. Plant J., 1999. 18(3): p. 329-36 [PMID:10377998] Villanueva JM, et al. INNER NO OUTER regulates abaxial- adaxial patterning in Arabidopsis ovules. Genes Dev., 1999. 13(23): p. 3160-9 [PMID:10601041] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Bellaoui M, et al. The Arabidopsis BELL1 and KNOX TALE homeodomain proteins interact through a domain conserved between plants and animals. Plant Cell, 2001. 13(11): p. 2455-70 [PMID:11701881] Balasubramanian S,Schneitz K NOZZLE links proximal-distal and adaxial-abaxial pattern formation during ovule development in Arabidopsis thaliana. Development, 2002. 129(18): p. 4291-300 [PMID:12183381] Modrusan Z,Reiser L,Feldmann KA,Fischer RL,Haughn GW Homeotic Transformation of Ovules into Carpel-like Structures in Arabidopsis. Plant Cell, 1994. 6(3): p. 333-349 [PMID:12244239] Robinson-Beers K,Pruitt RE,Gasser CS Ovule Development in Wild-Type Arabidopsis and Two Female-Sterile Mutants. Plant Cell, 1992. 4(10): p. 1237-1249 [PMID:12297633] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Meister RJ, et al. Definition and interactions of a positive regulatory element of the Arabidopsis INNER NO OUTER promoter. Plant J., 2004. 37(3): p. 426-38 [PMID:14731261] Smith HM,Campbell BC,Hake S Competence to respond to floral inductive signals requires the homeobox genes PENNYWISE and POUND-FOOLISH. Curr. Biol., 2004. 14(9): p. 812-7 [PMID:15120075] Hackbusch J,Richter K,Müller J,Salamini F,Uhrig JF A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins. Proc. Natl. Acad. Sci. U.S.A., 2005. 102(13): p. 4908-12 [PMID:15781858] Scofield S,Dewitte W,Murray JA The KNOX gene SHOOT MERISTEMLESS is required for the development of reproductive meristematic tissues in Arabidopsis. Plant J., 2007. 50(5): p. 767-81 [PMID:17461793] Wijeratne AJ, et al. Differential gene expression in Arabidopsis wild-type and mutant anthers: insights into anther cell differentiation and regulatory networks. Plant J., 2007. 52(1): p. 14-29 [PMID:17666023] Brambilla V, et al. Genetic and molecular interactions between BELL1 and MADS box factors support ovule development in Arabidopsis. Plant Cell, 2007. 19(8): p. 2544-56 [PMID:17693535] Kumar R, et al. The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins. Plant Cell, 2007. 19(9): p. 2719-35 [PMID:17873098] Magnani E,Hake S KNOX lost the OX: the Arabidopsis KNATM gene defines a novel class of KNOX transcriptional regulators missing the homeodomain. Plant Cell, 2008. 20(4): p. 875-87 [PMID:18398054] Skinner DJ,Gasser CS Expression-based discovery of candidate ovule development regulators through transcriptional profiling of ovule mutants. BMC Plant Biol., 2009. 9: p. 29 [PMID:19291320] Brambilla V,Kater M,Colombo L Ovule integument identity determination in Arabidopsis. Plant Signal Behav, 2008. 3(4): p. 246-7 [PMID:19704643] Brown RH,Nickrent DL,Gasser CS Expression of ovule and integument-associated genes in reduced ovules of Santalales. Evol. Dev., 2010 Mar-Apr. 12(2): p. 231-40 [PMID:20433462] Fernandez-Calvino L, et al. Arabidopsis plasmodesmal proteome. PLoS ONE, 2011. 6(4): p. e18880 [PMID:21533090] Tiwari A, et al. Parthenocarpic potential in Capsicum annuum L. is enhanced by carpelloid structures and controlled by a single recessive gene. BMC Plant Biol., 2011. 11: p. 143 [PMID:22018057] Bencivenga S,Simonini S,Benkov The transcription factors BEL1 and SPL are required for cytokinin and auxin signaling during ovule development in Arabidopsis. Plant Cell, 2012. 24(7): p. 2886-97 [PMID:22786869] Schiessl K,Kausika S,Southam P,Bush M,Sablowski R JAGGED controls growth anisotropyand coordination between cell sizeand cell cycle during plant organogenesis. Curr. Biol., 2012. 22(19): p. 1739-46 [PMID:22902754] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Yamada T,Sasaki Y,Hashimoto K,Nakajima K,Gasser CS CORONA, PHABULOSA and PHAVOLUTA collaborate with BELL1 to confine WUSCHEL expression to the nucellus in Arabidopsis ovules. Development, 2016. 143(3): p. 422-6 [PMID:26700684] Lozano-Sotomayor P, et al. Altered expression of the bZIP transcription factor DRINK ME affects growth and reproductive development in Arabidopsis thaliana. Plant J., 2016. 88(3): p. 437-451 [PMID:27402171] Ray A, et al. Arabidopsis floral homeotic gene BELL (BEL1) controls ovule development through negative regulation of AGAMOUS gene (AG). Proc. Natl. Acad. Sci. U.S.A., 1994. 91(13): p. 5761-5 [PMID:7912435] Reiser L, et al. The BELL1 gene encodes a homeodomain protein involved in pattern formation in the Arabidopsis ovule primordium. Cell, 1995. 83(5): p. 735-42 [PMID:8521490]