PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT5G41315.1

Common Name

BHLH1, EN31, GL3, MYC6, MYC6.2, SST

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

bHLH

Protein Properties

Length: 637aa MW: 70539.3 Da PI: 5.929

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT5G41315.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	43.4	6.2e-14	441	487	4	55
HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 +h E++RR+++N++f +Lr+++P+ + K +K++iL ++eY+++L+ AT5G41315.1 441 NHAVLEKKRREKLNERFMTLRKIIPSiN------KIDKVSILDDTIEYLQELE 487 7999********************77......**************995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF14215	8.2E-53	14	206	IPR025610	Transcription factor MYC/MYB N-terminal
PROSITE profile	PS50888	16.552	437	486	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	1.96E-17	440	501	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	1.93E-14	441	491	No hit	No description
Gene3D	G3DSA:4.10.280.10	5.5E-18	441	504	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	2.7E-11	441	487	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.6E-15	443	492	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007275	Biological Process	multicellular organism development
GO:0009957	Biological Process	epidermal cell fate specification
GO:0010091	Biological Process	trichome branching
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0005515	Molecular Function	protein binding
GO:0046983	Molecular Function	protein dimerization activity

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000263	anatomy	non-hair root epidermal cell
PO:0006504	anatomy	leaf trichome
PO:0007039	developmental stage	leaf trichome development stage

Sequence ? help Back to Top
Protein Sequence Length: 637 aa Download sequence Send to blast
MATGQNRTTV PENLKKHLAV SVRNIQWSYG IFWSVSASQS GVLEWGDGYY NGDIKTRKTI 60 QASEIKADQL GLRRSEQLSE LYESLSVAES SSSGVAAGSQ VTRRASAAAL SPEDLADTEW 120 YYLVCMSFVF NIGEGMPGRT FANGEPIWLC NAHTADSKVF SRSLLAKSAA VKTVVCFPFL 180 GGVVEIGTTE HITEDMNVIQ CVKTSFLEAP DPYATILPAR SDYHIDNVLD PQQILGDEIY 240 APMFSTEPFP TASPSRTTNG FDQEHEQVAD DHDSFMTERI TGGASQVQSW QLMDDELSNC 300 VHQSLNSSDC VSQTFVEGAA GRVAYGARKS RVQRLGQIQE QQRNVKTLSF DPRNDDVHYQ 360 SVISTIFKTN HQLILGPQFR NCDKQSSFTR WKKSSSSSSG TATVTAPSQG MLKKIIFDVP 420 RVHQKEKLML DSPEARDETG NHAVLEKKRR EKLNERFMTL RKIIPSINKI DKVSILDDTI 480 EYLQELERRV QELESCREST DTETRGTMTM KRKKPCDAGE RTSANCANNE TGNGKKVSVN 540 NVGEAEPADT GFTGLTDNLR IGSFGNEVVI ELRCAWREGV LLEIMDVISD LHLDSHSVQS 600 STGDGLLCLT VNCKHKGSKI ATPGMIKEAL QRVAWIC

Sequence ? help Back to Top

Protein Sequence Length: 637 aa Download sequence Send to blast

MATGQNRTTV PENLKKHLAV SVRNIQWSYG IFWSVSASQS GVLEWGDGYY NGDIKTRKTI  60
QASEIKADQL GLRRSEQLSE LYESLSVAES SSSGVAAGSQ VTRRASAAAL SPEDLADTEW  120
YYLVCMSFVF NIGEGMPGRT FANGEPIWLC NAHTADSKVF SRSLLAKSAA VKTVVCFPFL  180
GGVVEIGTTE HITEDMNVIQ CVKTSFLEAP DPYATILPAR SDYHIDNVLD PQQILGDEIY  240
APMFSTEPFP TASPSRTTNG FDQEHEQVAD DHDSFMTERI TGGASQVQSW QLMDDELSNC  300
VHQSLNSSDC VSQTFVEGAA GRVAYGARKS RVQRLGQIQE QQRNVKTLSF DPRNDDVHYQ  360
SVISTIFKTN HQLILGPQFR NCDKQSSFTR WKKSSSSSSG TATVTAPSQG MLKKIIFDVP  420
RVHQKEKLML DSPEARDETG NHAVLEKKRR EKLNERFMTL RKIIPSINKI DKVSILDDTI  480
EYLQELERRV QELESCREST DTETRGTMTM KRKKPCDAGE RTSANCANNE TGNGKKVSVN  540
NVGEAEPADT GFTGLTDNLR IGSFGNEVVI ELRCAWREGV LLEIMDVISD LHLDSHSVQS  600
STGDGLLCLT VNCKHKGSKI ATPGMIKEAL QRVAWIC

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4rqw_A	8e-16	6	206	5	192	Transcription factor MYC3
4rqw_B	8e-16	6	206	5	192	Transcription factor MYC3
4rs9_A	8e-16	6	206	5	192	Transcription factor MYC3
4yz6_A	8e-16	6	206	5	192	Transcription factor MYC3
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	446	451	KKRREK

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	186528230	0.0
Expression Atlas	AT5G41315	-
AtGenExpress	AT5G41315	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Localized in trichome developing region of leaves, prior to trichome initiation. Levels increase in initiating and young trichome cells, but dropped in the pavement cells between trichomes. Disappears in mature trichomes. {ECO:0000269\|PubMed:12917293}.
Uniprot	TISSUE SPECIFICITY: Mostly expressed in roots and flowers. Also present in stems and leaves, and, to a lower extent, in hypocotyls. Expressed in epidermal root hair cells (trichoblasts) and moves to root hairless cells (atrichoblasts) by a cell-to-cell movement through plasmodesmata (at protein level). {ECO:0000269\|PubMed:12679534, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:15590742}.

Functional Description ? help Back to Top
Source	Description
TAIR	encodes a basic helix loop helix domain protein that interacts with GL1 in trichome development.
UniProt	Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication. Regulates also trichome cell wall maturation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Activates the transcription of GL2. {ECO:0000269\|PubMed:11063707, ECO:0000269\|PubMed:12917293, ECO:0000269\|PubMed:12956536, ECO:0000269\|PubMed:14561633, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:15361138, ECO:0000269\|PubMed:15590742}.

Function -- GeneRIF ? help Back to Top
A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis. [PMID: 14561633] At1g01380 protein can inhibit the interaction between the positive trichome regulators GL1 and GL3, and likely limits trichome initiation via this inhibition. [GL3] [PMID: 15584952] GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis [GL3] [PMID: 15590742] A novel interaction between mutant alleles of GLABRA3 and SIAMESE, both required for differentiation, is reported. [PMID: 17764505] The role of GL3 in the initiation of trichomes from pluripotent epidermal cells in Arabidopsis is reported. [PMID: 17885086] Data show that GL3 associates with TRANSPARENT TESTA GLABRA1 in vivo, forming a complex. [PMID: 18434419] the role of GL3 in Arabidopsis trichome formation [PMID: 18547143] Expression levels of GL1, MYB23, GL2 and TTG1 were reduced in shoots of sad2 mutants while expression levels of GL3 and ENHANCER OF GLABRA3 (EGL3) were enhanced. [PMID: 18713401] Results suggest that patterning depends on the movement of the CAPRICE and GLABRA3 transcriptional regulators between epidermal cells. [PMID: 18816165] DNA binding of GL1 and GL3 via their own DNA-binding domains to the promoter of GL2 is probably required for the activation of GL2 expression. [PMID: 18948276] GL3 is a key transcription factor of wound-induced trichome formation acting downstream of jasmonic acid signaling in Arabidopsis [PMID: 19234066] 20 novel genes in the regulatory network involved in the trichome formation are the direct targets of GL3/GL1. [PMID: 19247443] Anthocyanins accumulate in both wild type and egl3, but not in gl3 loss-of-function mutants when depleted of nitrogen. [PMID: 19621239] The analysis of genes preferentially expressed in gl3-sst sim double mutant led to the identification of four additional genes required for normal trichome development. [PMID: 19626137] TTG1 trapping by GL3 is based on direct interaction between both proteins and recruitment in the nucleus. [PMID: 22028035] Nitrogen regulation of anthocyanin biosynthesis in Arabidopsis thaliana red cells undergoes a mechanism by which nitrogen controls the expression of genes encoding both main components of the TTG1-GL3/TT8-PAP1 complex and negative regulators. [PMID: 22669605] GL3::SlGL3 transformation did not show any obvious effect on trichome or non-hair cell differentiation; tomato and Arabidopsis partially use similar transcription factors for epidermal cell differentiation [PMID: 23326563] GL3 affects the expression of UPL3. [PMID: 23373825] Protein interaction analysis revealed that MYB82 physically interacts with GLABRA3. In addition, MYB82 and GL1 can form homodimers and heterodimers at R2R3-MYB domains, which may explain why their overexpression reduces trichome numbers. [PMID: 24803498] GL1 represses the activation of the TRY promoter by GL3 and TTG1, and TTG1 suppresses the activation of the CPC promoter by GL1 and GL3. [PMID: 25926482] overexpression did not influence anthocyanin biosynthesis in tomato fruit peel [PMID: 26039466] These results suggested that the Serine 92 in the conserved [D/E]Lx2 [R/K]x3Lx6Lx3R amino acid signature of GL1 is not essential for the interaction of GL1 and GL3, but may play a role in the binding of GL1 to the promoters of its target genes. [PMID: 26667588] Data indicate that GLABRA3 (GL3)-mediated gene expression was tissue specific. [PMID: 28216162] the C-terminal domain of the bHLH members (GLABRA3 [GL3], ENHANCER OF GLABRA3 [EGL3] and TRANSPARENT TESTA8 [TT8]) interacted with JAZs. [PMID: 29293407]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT5G41315.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By nitrogen deficiency and UV light. Negatively regulated by MYB66/WER, GL3 and BHLH2 in the developing non-hair cells, and positively regulated by CPC and TRY in the developing hair cells. {ECO:0000269\|PubMed:12679534, ECO:0000269\|PubMed:15590742, ECO:0000269\|PubMed:17053893}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT2G01570 (A), AT2G46410 (A), AT3G58070 (A), AT5G41315 (R)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT1G01380(A), AT1G79840(A), AT2G37260(A), AT2G46410(A), AT4G01060(A), AT4G09820(A), AT4G22880(R), AT5G08640(R), AT5G13930(R), AT5G41315(R), AT5G53200(A)

Interaction -- BIND ? help Back to Top
Source	Intact With	Description
BIND	AT1G56650	GL3 interacts with PAP1.
BIND	AT1G63650	EGL3 interacts with GL3.
BIND	AT1G66390	GL3 interacts with PAP2.
BIND	AT5G53200	GL3 interacts with TRY.
BIND	AT5G41315	GL3 interacts with another molecule of GL3.

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT2G30424, AT5G41315, AT5G52600, AT5G53200, AT1G14920, AT1G01380, AT1G56650, AT1G63650, AT1G66390
IntAct	Search Q9FN69

Phenotype -- Disruption Phenotype ? help Back to Top
Source	Description
UniProt	DISRUPTION PHENOTYPE: Plants exhibit two-branched trichomes instead of three-branched trichomes. {ECO:0000269\|PubMed:11063707}.

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT5G41315

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF246291	0.0	AF246291.1 Arabidopsis thaliana bHLH-transcription factor mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001332705.1	0.0	basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Swissprot	Q9FN69	0.0	GL3_ARATH; Transcription factor GLABRA 3
TrEMBL	A0A1P8BHU1	0.0	A0A1P8BHU1_ARATH; Basic helix-loop-helix (BHLH) DNA-binding superfamily protein
STRING	AT5G41315.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2592	28	67
Representative plant	OGRP2447	14	29

Link Out ? help Back to Top
Phytozome	AT5G41315.1
Entrez Gene	834133
iHOP	AT5G41315
wikigenes	AT5G41315

Publications ? help Back to Top
Luo D,Oppenheimer DG Genetic control of trichome branch number in Arabidopsis: the roles of the FURCA loci. Development, 1999. 126(24): p. 5547-57 [PMID:10572032] Walker JD,Oppenheimer DG,Concienne J,Larkin JC SIAMESE, a gene controlling the endoreduplication cell cycle in Arabidopsis thaliana trichomes. Development, 2000. 127(18): p. 3931-40 [PMID:10952891] Payne CT,Zhang F,Lloyd AM GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1. Genetics, 2000. 156(3): p. 1349-62 [PMID:11063707] Sawa S Overexpression of the AtmybL2 gene represses trichome development in Arabidopsis. DNA Res., 2002. 9(2): p. 31-4 [PMID:12056412] Schiefelbein J Cell-fate specification in the epidermis: a common patterning mechanism in the root and shoot. Curr. Opin. Plant Biol., 2003. 6(1): p. 74-8 [PMID:12495754] Heim MA, et al. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol. Biol. Evol., 2003. 20(5): p. 735-47 [PMID:12679534] Toledo-Ortiz G,Huq E,Quail PH The Arabidopsis basic/helix-loop-helix transcription factor family. Plant Cell, 2003. 15(8): p. 1749-70 [PMID:12897250] Zhang F,Gonzalez A,Zhao M,Payne CT,Lloyd A A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis. Development, 2003. 130(20): p. 4859-69 [PMID:12917293] Ramsay NA,Walker AR,Mooney M,Gray JC Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant. Plant Mol. Biol., 2003. 52(3): p. 679-88 [PMID:12956536] Kurata T, et al. The YORE-YORE gene regulates multiple aspects of epidermal cell differentiation in Arabidopsis. Plant J., 2003. 36(1): p. 55-66 [PMID:12974811] Esch JJ, et al. A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis. Development, 2003. 130(24): p. 5885-94 [PMID:14561633] Bernhardt C, et al. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Development, 2003. 130(26): p. 6431-9 [PMID:14627722] Zimmermann IM,Heim MA,Weisshaar B,Uhrig JF Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J., 2004. 40(1): p. 22-34 [PMID:15361138] Montiel G,Gantet P,Jay-Allemand C,Breton C Transcription factor networks. Pathways to the knowledge of root development. Plant Physiol., 2004. 136(3): p. 3478-85 [PMID:15542499] Esch JJ,Chen MA,Hillestad M,Marks MD Comparison of TRY and the closely related At1g01380 gene in controlling Arabidopsis trichome patterning. Plant J., 2004. 40(6): p. 860-9 [PMID:15584952] Bernhardt C,Zhao M,Gonzalez A,Lloyd A,Schiefelbein J The bHLH genes GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis. Development, 2005. 132(2): p. 291-8 [PMID:15590742] Kirik V,Simon M,Wester K,Schiefelbein J,Hulskamp M ENHANCER of TRY and CPC 2 (ETC2) reveals redundancy in the region-specific control of trichome development of Arabidopsis. Plant Mol. Biol., 2004. 55(3): p. 389-98 [PMID:15604688] Kirik V, et al. Functional diversification of MYB23 and GL1 genes in trichome morphogenesis and initiation. Development, 2005. 132(7): p. 1477-85 [PMID:15728674] Serna L Epidermal cell patterning and differentiation throughout the apical-basal axis of the seedling. J. Exp. Bot., 2005. 56(418): p. 1983-9 [PMID:15967776] Dolan L Positional information and mobile transcriptional regulators determine cell pattern in the Arabidopsis root epidermis. J. Exp. Bot., 2006. 57(1): p. 51-4 [PMID:16317033] Gan Y, et al. GLABROUS INFLORESCENCE STEMS modulates the regulation by gibberellins of epidermal differentiation and shoot maturation in Arabidopsis. Plant Cell, 2006. 18(6): p. 1383-95 [PMID:16679458] Baudry A,Caboche M,Lepiniec L TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana. Plant J., 2006. 46(5): p. 768-79 [PMID:16709193] Kwak SH,Schiefelbein J The role of the SCRAMBLED receptor-like kinase in patterning the Arabidopsis root epidermis. Dev. Biol., 2007. 302(1): p. 118-31 [PMID:17027738] Lea US,Slimestad R,Smedvig P,Lillo C Nitrogen deficiency enhances expression of specific MYB and bHLH transcription factors and accumulation of end products in the flavonoid pathway. Planta, 2007. 225(5): p. 1245-53 [PMID:17053893] Chen ZH,Nimmo GA,Jenkins GI,Nimmo HG BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis. Biochem. J., 2007. 405(1): p. 191-8 [PMID:17376028] Wang S,Chang Y,Guo J,Chen JG Arabidopsis Ovate Family Protein 1 is a transcriptional repressor that suppresses cell elongation. Plant J., 2007. 50(5): p. 858-72 [PMID:17461792] Tominaga R,Iwata M,Okada K,Wada T Functional analysis of the epidermal-specific MYB genes CAPRICE and WEREWOLF in Arabidopsis. Plant Cell, 2007. 19(7): p. 2264-77 [PMID:17644729] Gan Y,Yu H,Peng J,Broun P Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis. Plant Physiol., 2007. 145(3): p. 1031-42 [PMID:17704233] Marks MD,Gilding E,Wenger JP Genetic interaction between glabra3-shapeshifter and siamese in Arabidopsis thaliana converts trichome precursors into cells with meristematic activity. Plant J., 2007. 52(2): p. 352-61 [PMID:17764505] Cominelli E, et al. Expression analysis of anthocyanin regulatory genes in response to different light qualities in Arabidopsis thaliana. J. Plant Physiol., 2008. 165(8): p. 886-94 [PMID:17766004] Ishida T, et al. Arabidopsis TRANSPARENT TESTA GLABRA2 is directly regulated by R2R3 MYB transcription factors and is involved in regulation of GLABRA2 transcription in epidermal differentiation. Plant Cell, 2007. 19(8): p. 2531-43 [PMID:17766401] Morohashi K, et al. Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory events. Plant Physiol., 2007. 145(3): p. 736-46 [PMID:17885086] Lillo C,Lea US,Ruoff P Nutrient depletion as a key factor for manipulating gene expression and product formation in different branches of the flavonoid pathway. Plant Cell Environ., 2008. 31(5): p. 587-601 [PMID:18031469] Gonzalez A,Zhao M,Leavitt JM,Lloyd AM Regulation of the anthocyanin biosynthetic pathway by the TTG1/bHLH/Myb transcriptional complex in Arabidopsis seedlings. Plant J., 2008. 53(5): p. 814-27 [PMID:18036197] Wang Y, et al. Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana. J. Plant Res., 2008. 121(1): p. 87-96 [PMID:18060349] Basu D,Le J,Zakharova T,Mallery EL,Szymanski DB A SPIKE1 signaling complex controls actin-dependent cell morphogenesis through the heteromeric WAVE and ARP2/3 complexes. Proc. Natl. Acad. Sci. U.S.A., 2008. 105(10): p. 4044-9 [PMID:18308939] Marks MD,Esch J,Herman P,Sivakumaran S,Oppenheimer D A model for cell-type determination and differentiation in plants. Symp. Soc. Exp. Biol., 1991. 45: p. 77-87 [PMID:1843415] Zhao M,Morohashi K,Hatlestad G,Grotewold E,Lloyd A The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci. Development, 2008. 135(11): p. 1991-9 [PMID:18434419] Dubos C, et al. MYBL2 is a new regulator of flavonoid biosynthesis in Arabidopsis thaliana. Plant J., 2008. 55(6): p. 940-53 [PMID:18532978] Bouyer D, et al. Two-dimensional patterning by a trapping/depletion mechanism: the role of TTG1 and GL3 in Arabidopsis trichome formation. PLoS Biol., 2008. 6(6): p. e141 [PMID:18547143] Kaminuma E,Yoshizumi T,Wada T,Matsui M,Toyoda T Quantitative analysis of heterogeneous spatial distribution of Arabidopsis leaf trichomes using micro X-ray computed tomography. Plant J., 2008. 56(3): p. 470-82 [PMID:18643999] Wang S, et al. Comprehensive analysis of single-repeat R3 MYB proteins in epidermal cell patterning and their transcriptional regulation in Arabidopsis. BMC Plant Biol., 2008. 8: p. 81 [PMID:18644155] Shangguan XX,Xu B,Yu ZX,Wang LJ,Chen XY Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco. J. Exp. Bot., 2008. 59(13): p. 3533-42 [PMID:18711121] Gao Y, et al. SAD2 in Arabidopsis functions in trichome initiation through mediating GL3 function and regulating GL1, TTG1 and GL2 expression. J Integr Plant Biol, 2008. 50(7): p. 906-17 [PMID:18713401] Digiuni S, et al. A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves. Mol. Syst. Biol., 2008. 4: p. 217 [PMID:18766177] Savage NS, et al. A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis. PLoS Biol., 2008. 6(9): p. e235 [PMID:18816165] Wang S,Chen JG Arabidopsis transient expression analysis reveals that activation of GLABRA2 may require concurrent binding of GLABRA1 and GLABRA3 to the promoter of GLABRA2. Plant Cell Physiol., 2008. 49(12): p. 1792-804 [PMID:18948276] Ben Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: a dynamic spatial model. BMC Syst Biol, 2008. 2: p. 98 [PMID:19014692] Olsen KM, et al. Temperature and nitrogen effects on regulators and products of the flavonoid pathway: experimental and kinetic model studies. Plant Cell Environ., 2009. 32(3): p. 286-99 [PMID:19054348] Yoshida Y,Sano R,Wada T,Takabayashi J,Okada K Jasmonic acid control of GLABRA3 links inducible defense and trichome patterning in Arabidopsis. Development, 2009. 136(6): p. 1039-48 [PMID:19234066] Morohashi K,Grotewold E A systems approach reveals regulatory circuitry for Arabidopsis trichome initiation by the GL3 and GL1 selectors. PLoS Genet., 2009. 5(2): p. e1000396 [PMID:19247443] Wester K, et al. Functional diversity of R3 single-repeat genes in trichome development. Development, 2009. 136(9): p. 1487-96 [PMID:19336467] Kang YH, et al. The MYB23 gene provides a positive feedback loop for cell fate specification in the Arabidopsis root epidermis. Plant Cell, 2009. 21(4): p. 1080-94 [PMID:19395683] Shan X,Zhang Y,Peng W,Wang Z,Xie D Molecular mechanism for jasmonate-induction of anthocyanin accumulation in Arabidopsis. J. Exp. Bot., 2009. 60(13): p. 3849-60 [PMID:19596700] Tominaga-Wada R, et al. The GLABRA2 homeodomain protein directly regulates CESA5 and XTH17 gene expression in Arabidopsis roots. Plant J., 2009. 60(3): p. 564-74 [PMID:19619157] Feyissa DN,Løvdal T,Olsen KM,Slimestad R,Lillo C The endogenous GL3, but not EGL3, gene is necessary for anthocyanin accumulation as induced by nitrogen depletion in Arabidopsis rosette stage leaves. Planta, 2009. 230(4): p. 747-54 [PMID:19621239] Marks MD,Wenger JP,Gilding E,Jilk R,Dixon RA Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development. 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