PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G39760.1
Common NameAtHB23, HB23, MKM21.8, ZHD10
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ZF-HD
Protein Properties Length: 334aa    MW: 36386 Da    PI: 8.4372
Description homeobox protein 23
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G39760.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1ZF-HD_dimer107.38.9e-3454110459
  ZF-HD_dimer   4 vrYkeClkNhAaslGghavDGCgEfmpsegee.gtaaalkCaACgCHRnFHRrevee 59 
                  ++YkeClkNhAa+lGgha+DGCgEfmps+++  +++++lkCaACgCHRnFHRr++++
  AT5G39760.1  54 FTYKECLKNHAAALGGHALDGCGEFMPSPSSIsSDPTSLKCAACGCHRNFHRRDPDN 110
                  68**************************9999899******************9886 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF047706.9E-2855108IPR006456ZF-HD homeobox protein, Cys/His-rich dimerisation domain
TIGRFAMsTIGR015661.8E-3155107IPR006456ZF-HD homeobox protein, Cys/His-rich dimerisation domain
PROSITE profilePS5152327.62956107IPR006456ZF-HD homeobox protein, Cys/His-rich dimerisation domain
ProDomPD1257742.0E-1956123IPR006456ZF-HD homeobox protein, Cys/His-rich dimerisation domain
SuperFamilySSF466891.73E-17188261IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.602.4E-28189261IPR009057Homeodomain-like
TIGRFAMsTIGR015657.3E-25200257IPR006455Homeodomain, ZF-HD class
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009739Biological Processresponse to gibberellin
GO:0009740Biological Processgibberellic acid mediated signaling pathway
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0046872Molecular Functionmetal ion binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 334 aa     Download sequence    Send to blast
MMDMTPTITT TTTPTPKSPE PESETPTRIQ PAKPISFSNG IIKRHHHHHH PLLFTYKECL  60
KNHAAALGGH ALDGCGEFMP SPSSISSDPT SLKCAACGCH RNFHRRDPDN NNDSSQIPPP  120
PSTAVEYQPH HRHHPPPPPP PPPPRSPNSA SPPPISSSYM LLSLSGTNNN NNNLASFSDL  180
NFSAGNNHHH HHQHTLHGSR KRFRTKFSQF QKEKMHEFAE RVGWKMQKRD EDDVRDFCRQ  240
IGVDKSVLKV WMHNNKNTFN RRDIAGNEIR QIDNGGGNHT PILAGEINNH NNGHHGVGGG  300
GELHQSVSSG GGGGGFDSDS GGANGGNVNG SSSS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1wh7_A7e-201992581675ZF-HD homeobox family protein
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.93610.0bud| root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306934730.0
Genevisible249422_at0.0
Expression AtlasAT5G39760-
AtGenExpressAT5G39760-
ATTED-IIAT5G39760-
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: In young leaves, accumulates in the adaxial domain of leaf primordia and the rib meristem. {ECO:0000269|PubMed:17387478}.
UniprotTISSUE SPECIFICITY: Mostly expressed in rosettes (e.g. young leaves), flowers (e.g. styles), siliques and inflorescence. {ECO:0000269|PubMed:16428600, ECO:0000269|PubMed:17387478}.
Functional Description ? help Back to Top
Source Description
UniProtPutative transcription factor. Probably involved in establishing polarity during leaf development through the gibberellic acid (GA) signaling pathway. {ECO:0000269|PubMed:17387478}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00536DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G39760.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By gibberellic acid (GA). {ECO:0000269|PubMed:17387478}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G42780, AT5G65410, AT1G14687
IntActSearch Q9FIW9
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G39760
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0168760.0AB016876.1 Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MKM21.
GenBankAK2284840.0AK228484.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL15-09-C01.
GenBankAY0910340.0AY091034.1 Arabidopsis thaliana unknown protein (At5g39760) mRNA, complete cds.
GenBankAY1173470.0AY117347.1 Arabidopsis thaliana unknown protein (At5g39760) mRNA, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_568570.10.0homeobox protein 23
SwissprotQ9FIW90.0ZHD10_ARATH; Zinc-finger homeodomain protein 10
TrEMBLA0A178UJT30.0A0A178UJT3_ARATH; ZHD10
STRINGAT5G39760.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM22202575
Representative plantOGRP9116237
Publications ? help Back to Top
  1. Windhövel A,Hein I,Dabrowa R,Stockhaus J
    Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.
    Plant Mol. Biol., 2001. 45(2): p. 201-14
    [PMID:11289511]
  2. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  3. Tan QK,Irish VF
    The Arabidopsis zinc finger-homeodomain genes encode proteins with unique biochemical properties that are coordinately expressed during floral development.
    Plant Physiol., 2006. 140(3): p. 1095-108
    [PMID:16428600]
  4. Kim YK, et al.
    ATHB23, an Arabidopsis class I homeodomain-leucine zipper gene, is expressed in the adaxial region of young leaves.
    Plant Cell Rep., 2007. 26(8): p. 1179-85
    [PMID:17387478]
  5. Ballvora A, et al.
    Comparative sequence analysis of Solanum and Arabidopsis in a hot spot for pathogen resistance on potato chromosome V reveals a patchwork of conserved and rapidly evolving genome segments.
    BMC Genomics, 2007. 8: p. 112
    [PMID:17474978]
  6. Hu W,dePamphilis CW,Ma H
    Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini zinc finger gene families.
    J Integr Plant Biol, 2008. 50(8): p. 1031-45
    [PMID:18713354]
  7. Hong SY,Kim OK,Kim SG,Yang MS,Park CM
    Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor in Arabidopsis.
    J. Biol. Chem., 2011. 286(2): p. 1659-68
    [PMID:21059647]
  8. Brady SM, et al.
    A stele-enriched gene regulatory network in the Arabidopsis root.
    Mol. Syst. Biol., 2011. 7: p. 459
    [PMID:21245844]
  9. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  10. Kazama D,Kurusu T,Mitsuda N,Ohme-Takagi M,Tada Y
    Involvement of elevated proline accumulation in enhanced osmotic stress tolerance in Arabidopsis conferred by chimeric repressor gene silencing technology.
    Plant Signal Behav, 2014. 9(3): p. e28211
    [PMID:24614501]
  11. Ribone PA,Capella M,Chan RL
    Functional characterization of the homeodomain leucine zipper I transcription factor AtHB13 reveals a crucial role in Arabidopsis development.
    J. Exp. Bot., 2015. 66(19): p. 5929-43
    [PMID:26136262]
  12. Kazama D, et al.
    Identification of Chimeric Repressors that Confer Salt and Osmotic Stress Tolerance in Arabidopsis.
    Plants (Basel), 2013. 2(4): p. 769-85
    [PMID:27137403]