PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G22890.1
Common NameSTOP2
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 373aa    MW: 42249.7 Da    PI: 8.5299
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G22890.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H223.21.7e-07217239123
                  EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  + C++Cgk F+r  nL+ H+r H
  AT5G22890.1 217 HYCQICGKGFKRDANLRMHMRAH 239
                  68*******************99 PP
2zf-C2H211.80.00074338353621
                  TTEEESSHHHHHHHHH CS
      zf-C2H2   6 CgksFsrksnLkrHir 21 
                  Cg+ Fsrk+ L++H +
  AT5G22890.1 338 CGTKFSRKDKLMSHVS 353
                  **************86 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576674.92E-6215242No hitNo description
PROSITE profilePS5015712.632217244IPR007087Zinc finger, C2H2
SMARTSM003550.0028217239IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.603.4E-6217244IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS000280219239IPR007087Zinc finger, C2H2
SMARTSM00355230268301IPR015880Zinc finger, C2H2-like
SMARTSM0035573306328IPR015880Zinc finger, C2H2-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010200Biological Processresponse to chitin
GO:0003676Molecular Functionnucleic acid binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0009005anatomyroot
Sequence ? help Back to Top
Protein Sequence    Length: 373 aa     Download sequence    Send to blast
MHIHMMNRDE HIAKKVEGSI SSFSGETSTS SKQIYVNPVT TTGTKSMEDD DVSLSLLYNL  60
STLHEKVHQI QSLVSFYMVS TNNINQSSGS TSLAVANIGS LVQEIITAAS SMLYTCQQLQ  120
IGSNNNNNDI DNDQTVDAMV LEFSRQETDP GHDFVQESTN LFGVQERGQI SFPDQNLDWY  180
NTETINPKKD KHRSKPSSGS YDILELDVAD LLAKYTHYCQ ICGKGFKRDA NLRMHMRAHG  240
DEYKTREALI SPTSQDKKGG YSLKKHYYSC PQHGCRWNQR HEKFQPLKSV ICAKNHYKRS  300
HCPKMYMCRR CSVKHFSVLS DLRTHEKHCG DIKWVCSCGT KFSRKDKLMS HVSLFLGHVP  360
AHGSSKPPTI TLK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.310360.0root
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible249882_at0.0
Expression AtlasAT5G22890-
AtGenExpressAT5G22890-
ATTED-IIAT5G22890-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed at low levels in roots (e.g. root tips and lateral roots), leaves (e.g. at the edge of mature leaves, possibly in hydathodes, and in vascular bundles), flowers (e.g. floral filaments), stems, siliques and cotyledons. {ECO:0000269|PubMed:23935008}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor. Together with STOP1, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269|PubMed:23935008}.
Function -- GeneRIF ? help Back to Top
  1. STOP2, a STOP1 homolog, partially recovered Al- and low pH-tolerance by recovering the expression of genes regulated by STOP1.
    [PMID: 23935008]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00522DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G22890.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G22890
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0052430.0AB005243.1 Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone:MRN17.
GenBankAK2277400.0AK227740.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL14-31-P16.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_197680.20.0C2H2 and C2HC zinc fingers superfamily protein
SwissprotQ0WT240.0STOP2_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 2
TrEMBLA0A178UH710.0A0A178UH71_ARATH; Uncharacterized protein
STRINGAT5G22890.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM57522547
Representative plantOGRP8301663
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  3. Iuchi S, et al.
    Zinc finger protein STOP1 is critical for proton tolerance in Arabidopsis and coregulates a key gene in aluminum tolerance.
    Proc. Natl. Acad. Sci. U.S.A., 2007. 104(23): p. 9900-5
    [PMID:17535918]
  4. Libault M,Wan J,Czechowski T,Udvardi M,Stacey G
    Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor.
    Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11
    [PMID:17722694]
  5. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  6. Kobayashi Y, et al.
    STOP2 activates transcription of several genes for Al- and low pH-tolerance that are regulated by STOP1 in Arabidopsis.
    Mol Plant, 2014. 7(2): p. 311-22
    [PMID:23935008]