PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT5G22570.1

Common Name

ATWRKY38, MQJ16.11, WRKY38

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

WRKY

Protein Properties

Length: 289aa MW: 33268.2 Da PI: 5.4096

Description

WRKY DNA-binding protein 38

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT5G22570.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	WRKY	63.4	3.8e-20	111	170	3	59
-SS-EEEEEEE--TT-SS-EEEEEE-ST...T---EEEEEE-SSSTTEEEEEEES--SS- CS WRKY 3 DgynWrKYGqKevkgsefprsYYrCtsa...gCpvkkkversaedpkvveitYegeHnhe 59 Dgy WrKYGqK++k+s++ rsYYrC+++ +C+++k+ ++ +++p v +tY g+H+++ AT5G22570.1 111 DGYLWRKYGQKSIKKSNHQRSYYRCSYNkdhNCEARKHEQKIKDNPPVYRTTYFGHHTCK 170 9************************99999************************97 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50811	19.749	104	172	IPR003657	WRKY domain
Gene3D	G3DSA:2.20.25.80	2.0E-21	104	170	IPR003657	WRKY domain
SuperFamily	SSF118290	6.54E-21	107	171	IPR003657	WRKY domain
SMART	SM00774	2.1E-31	109	171	IPR003657	WRKY domain
Pfam	PF03106	8.0E-21	111	170	IPR003657	WRKY domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009863	Biological Process	salicylic acid mediated signaling pathway
GO:0042742	Biological Process	defense response to bacterium
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0005515	Molecular Function	protein binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009047	anatomy	stem
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0025022	anatomy	collective leaf structure
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 289 aa Download sequence Send to blast
MEMNSPHEKA VQAIRYGHSC AMRLKRRLNH PMADGGPLSS YDLAKSIVES FSNAISILSA 60 KPETEDDQFS DLSSRDSSPP PQGSPSKKRK IDSTNSSENW RDDSPDPIYY DGYLWRKYGQ 120 KSIKKSNHQR SYYRCSYNKD HNCEARKHEQ KIKDNPPVYR TTYFGHHTCK TEHNLDAIFI 180 AGQDPLDDFK STQMIRFGKD QDQEKESRSN GFSLSVKHEE DIIKEQAIDQ YREITSNDQD 240 CQDVIEEYLS SPSGSYPPSS SSGSESADFN SDLLFDNPDS WDRYDQFYF

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6ir8_A	8e-15	111	170	10	69	OsWRKY45
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.27347	0.0	root

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30688539	0.0
Genevisible	249890_at	0.0
Expression Atlas	AT5G22570	-
AtGenExpress	AT5G22570	-
ATTED-II	AT5G22570	-

Functional Description ? help Back to Top
Source	Description
TAIR	member of WRKY Transcription Factor; Group III
UniProt	Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). {ECO:0000250}.

Function -- GeneRIF ? help Back to Top
WRKY38 and WRKY62 are transcriptional activators in plant cells that function additively as negative regulators of plant basal defense, but their activation activities are abolished by overexpressed HDA19. [PMID: 18776063] results suggest that PKS5 functions at the upstream of NPR1 and might mediate expression of WRKY38 and WRKY62 possibly by interacting with and phosphorylating NPR1. [PMID: 20621018]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00619	PBM	24477691	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT5G22570.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT2G14610(R)

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	salicylic acid

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G80840
IntAct	Search Q8GWF1

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT5G22570

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK118884	0.0	AK118884.1 Arabidopsis thaliana At5g22570 mRNA for putative WRKY transcription factor 38 (WRKY38), complete cds, clone: RAFL21-21-O16.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_197649.2	0.0	WRKY DNA-binding protein 38
Swissprot	Q8GWF1	0.0	WRK38_ARATH; Probable WRKY transcription factor 38
TrEMBL	A0A178UNG1	0.0	A0A178UNG1_ARATH; WRKY38
STRING	AT5G22570.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM13673	17	27
Representative plant	OGRP14	17	875

Link Out ? help Back to Top
Phytozome	AT5G22570.1
Entrez Gene	832320
iHOP	AT5G22570
wikigenes	AT5G22570

Publications ? help Back to Top
Eulgem T,Rushton PJ,Robatzek S,Somssich IE The WRKY superfamily of plant transcription factors. Trends Plant Sci., 2000. 5(5): p. 199-206 [PMID:10785665] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Seki M, et al. Functional annotation of a full-length Arabidopsis cDNA collection. Science, 2002. 296(5565): p. 141-5 [PMID:11910074] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Hoth S, et al. Monitoring genome-wide changes in gene expression in response to endogenous cytokinin reveals targets in Arabidopsis thaliana. FEBS Lett., 2003. 554(3): p. 373-80 [PMID:14623097] Gong W, et al. Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes. Plant Physiol., 2004. 135(2): p. 773-82 [PMID:15208423] Scheible WR, et al. Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen. Plant Physiol., 2004. 136(1): p. 2483-99 [PMID:15375205] Thilmony R,Underwood W,He SY Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7. Plant J., 2006. 46(1): p. 34-53 [PMID:16553894] Che P,Lall S,Nettleton D,Howell SH Gene expression programs during shoot, root, and callus development in Arabidopsis tissue culture. Plant Physiol., 2006. 141(2): p. 620-37 [PMID:16648215] Wang D,Amornsiripanitch N,Dong X A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants. PLoS Pathog., 2006. 2(11): p. e123 [PMID:17096590] Sato M, et al. A high-performance, small-scale microarray for expression profiling of many samples in Arabidopsis-pathogen studies. Plant J., 2007. 49(3): p. 565-77 [PMID:17181774] Krinke O, et al. Phosphatidylinositol 4-kinase activation is an early response to salicylic acid in Arabidopsis suspension cells. Plant Physiol., 2007. 144(3): p. 1347-59 [PMID:17496105] Wang Z, et al. Identification and characterization of COI1-dependent transcription factor genes involved in JA-mediated response to wounding in Arabidopsis plants. Plant Cell Rep., 2008. 27(1): p. 125-35 [PMID:17786451] Ciolkowski I,Wanke D,Birkenbihl RP,Somssich IE Studies on DNA-binding selectivity of WRKY transcription factors lend structural clues into WRKY-domain function. Plant Mol. Biol., 2008. 68(1-2): p. 81-92 [PMID:18523729] Ascencio-Ib Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. Plant Physiol., 2008. 148(1): p. 436-54 [PMID:18650403] Kim KC,Lai Z,Fan B,Chen Z Arabidopsis WRKY38 and WRKY62 transcription factors interact with histone deacetylase 19 in basal defense. Plant Cell, 2008. 20(9): p. 2357-71 [PMID:18776063] Xie C,Zhou X,Deng X,Guo Y PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62. J Genet Genomics, 2010. 37(6): p. 359-69 [PMID:20621018] Hanada K, et al. Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana. Mol. Biol. Evol., 2011. 28(1): p. 377-82 [PMID:20736450] Arabidopsis Interactome Mapping Consortium Evidence for network evolution in an Arabidopsis interactome map. Science, 2011. 333(6042): p. 601-7 [PMID:21798944] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Singh V,Roy S,Singh D,Nandi AK Arabidopsis flowering locus D influences systemic-acquired-resistance- induced expression and histone modifications of WRKY genes. J. Biosci., 2014. 39(1): p. 119-26 [PMID:24499796] Janda M, et al. Phospholipase D affects translocation of NPR1 to the nucleus in Arabidopsis thaliana. Front Plant Sci, 2015. 6: p. 59 [PMID:25741350] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178]