PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G03415.2
Common NameATDPB, DP1, DPB, F12E4.160
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 379aa    MW: 41991.3 Da    PI: 6.1372
Description Transcription factor DP
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G03415.2genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.91.7e-231051761671
      E2F_TDP  16 lleksee.givtlnevakeLvse................dvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  l+ek+e+ g++t+neva+eLv+e                d+kn+rRR+YD+lNVL+a+++i+k +k+ei+w+g
  AT5G03415.2 105 LCEKVESkGRTTYNEVADELVAEfalpnndgtspdqqqyDEKNIRRRVYDALNVLMAMDIISK-DKKEIQWRG 176
                  79999999*******************************************************.*******98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PIRSFPIRSF0094041.1E-1341379IPR015648Transcription factor DP
SMARTSM013729.6E-2748176IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.109.8E-38105182IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.5E-17105177IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.9E-21105176IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd144585.14E-43181284IPR014889Transcription factor DP, C-terminal
SMARTSM011381.6E-69183338IPR014889Transcription factor DP, C-terminal
SuperFamilySSF1440747.32E-43183334No hitNo description
PfamPF087811.6E-42184301IPR014889Transcription factor DP, C-terminal
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000082Biological ProcessG1/S transition of mitotic cell cycle
GO:0006357Biological Processregulation of transcription from RNA polymerase II promoter
GO:0042023Biological ProcessDNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0000981Molecular FunctionRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677Molecular FunctionDNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 379 aa     Download sequence    Send to blast
MTTTGSNSNH NHHESNNNNN NPSTRSWGTA VSGQSVSTSG SMGSPSSRSE QTITVVTSTS  60
DTTFQRLNNL DIQGDDAGSQ GASGVKKKKR GQRAAGPDKT GRGLLCEKVE SKGRTTYNEV  120
ADELVAEFAL PNNDGTSPDQ QQYDEKNIRR RVYDALNVLM AMDIISKDKK EIQWRGLPRT  180
SLSDIEELKN ERLSLRNRIE KKTAYSQELE EQYVGLQNLI QRNEHLYSSG NAPSGGVALP  240
FILVQTRPHA TVEVEISEDM QLVHFDFNST PFELHDDNFV LKTMKFCDQP PQQPNGRNNS  300
QLVCHNFTPE NPNKGPSTGP TPQLDMYETH LQSQQHQQHS QLQIIPMPET NNVTSSADTA  360
PVKSPSLPGI MNSSMKPEN
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_B6e-3093181193PROTEIN (TRANSCRIPTION FACTOR DP-2)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.48640.0flower| root
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible250953_at0.0
Expression AtlasAT5G03415-
AtGenExpressAT5G03415-
ATTED-IIAT5G03415-
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed during the whole cell cycle. {ECO:0000269|PubMed:11669580}.
UniprotTISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16920782}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a homolog of the animal DP protein. DP, in animals, forms a heterodimer with E2F and plays a central role in G1/S transition in the cell division cycle. DPB has been shown to interact with non phosphorylated E2Fc; when E2Fc is phosphorylated, the formation of the E2Fc/DPB heterodimer is lost.
UniProtInvolved in the regulation of the G1/S transition. Increases the DNA binding activity of E2F proteins after heterodimerization. The complex DPB/E2FC restricts cell division and lateral root initiation and may function as a negative regulator of E2F-regulated genes. The interaction with SKP2A is controlled by auxin. {ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:16920782}.
Function -- GeneRIF ? help Back to Top
  1. The interaction of E2FC with DPB is a key factor in controlling the balance between cell proliferation and the switch to the endocycle program.
    [PMID: 16920782]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G03415.2
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G22220, AT1G47870
IntActSearch Q9FNY2
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G03415
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ2945320.0AJ294532.1 Arabidopsis thaliana mRNA for DP-like protein (dpb gene).
GenBankAK2281480.0AK228148.1 Arabidopsis thaliana mRNA for transcription factor - like protein, complete cds, clone: RAFL14-61-J08.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001190214.10.0Transcription factor DP
SwissprotQ9FNY20.0DPB_ARATH; Transcription factor-like protein DPB
TrEMBLA0A178UIJ90.0A0A178UIJ9_ARATH; DPB
STRINGBostr.2128s0112.1.p0.0(Boechera stricta)
Publications ? help Back to Top
  1. Magyar Z,Atanassova A,De Veylder L,Rombauts S,Inzé D
    Characterization of two distinct DP-related genes from Arabidopsis thaliana.
    FEBS Lett., 2000. 486(1): p. 79-87
    [PMID:11108847]
  2. de Jager SM,Menges M,Bauer UM,Murra JA
    Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities.
    Plant Mol. Biol., 2001. 47(4): p. 555-68
    [PMID:11669580]
  3. Mariconti L, et al.
    The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.
    J. Biol. Chem., 2002. 277(12): p. 9911-9
    [PMID:11786543]
  4. Kosugi S,Ohashi Y
    E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form.
    J. Biol. Chem., 2002. 277(19): p. 16553-8
    [PMID:11867638]
  5. Kosugi S,Ohashi Y
    Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation.
    Plant Physiol., 2002. 128(3): p. 833-43
    [PMID:11891240]
  6. Kosugi S,Ohashi Y
    E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters.
    Plant J., 2002. 29(1): p. 45-59
    [PMID:12060226]
  7. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
    [PMID:14576160]
  8. Magyar Z, et al.
    The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division.
    Plant Cell, 2005. 17(9): p. 2527-41
    [PMID:16055635]
  9. del Pozo JC,Diaz-Trivino S,Cisneros N,Gutierrez C
    The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.
    Plant Cell, 2006. 18(9): p. 2224-35
    [PMID:16920782]
  10. Wagner R,Pfannschmidt T
    Eukaryotic transcription factors in plastids--Bioinformatic assessment and implications for the evolution of gene expression machineries in plants.
    Gene, 2006. 381: p. 62-70
    [PMID:16934950]
  11. Jurado S, et al.
    SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway.
    Plant J., 2008. 53(5): p. 828-41
    [PMID:18036202]
  12. Yuan J, et al.
    In silico comparison of transcript abundances during Arabidopsis thaliana and Glycine max resistance to Fusarium virguliforme.
    BMC Genomics, 2008. 9 Suppl 2: p. S6
    [PMID:18831797]
  13. Boruc J, et al.
    Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network.
    Plant Cell, 2010. 22(4): p. 1264-80
    [PMID:20407024]
  14. Van Leene J, et al.
    Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.
    Mol. Syst. Biol., 2010. 6: p. 397
    [PMID:20706207]
  15. Jurado S, et al.
    The Arabidopsis cell cycle F-box protein SKP2A binds to auxin.
    Plant Cell, 2010. 22(12): p. 3891-904
    [PMID:21139066]