PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT5G02470.3

Common Name

DP2, DP2A, DPA, T22P11.60

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

E2F/DP

Protein Properties

Length: 292aa MW: 33038.5 Da PI: 7.2385

Description

Transcription factor DP

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT5G02470.3	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	75	7.4e-24	51	133	3	71
E2F_TDP 3 eksLrlltqkflklleksee.givtlnevakeLvse.................dvknkrRRiYDilNVLealnliekkekneirwkg 71 + +Lr+++ + +++k e+ +i+t++eva+e++s+ ++kn+rRR+YD+lNV++al++i++ +k+eirwkg AT5G02470.3 51 GGGLRQFSVM---VCQKLEAkKITTYKEVADEIISDfatikqnaekplneneyNEKNIRRRVYDALNVFMALDIIAR-DKKEIRWKG 133 6799999999...**9999****************************************************.*****98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PIRSF	PIRSF009404	4.6E-99	2	290	IPR015648	Transcription factor DP
Gene3D	G3DSA:1.10.10.10	5.0E-36	46	137	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	4.4E-29	49	133	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	7.6E-20	52	133	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.35E-18	52	134	IPR011991	Winged helix-turn-helix DNA-binding domain
CDD	cd14458	1.32E-28	140	241	IPR014889	Transcription factor DP, C-terminal
SuperFamily	SSF144074	2.04E-38	140	282	No hit	No description
SMART	SM01138	1.8E-52	140	292	IPR014889	Transcription factor DP, C-terminal
Pfam	PF08781	8.1E-33	141	264	IPR014889	Transcription factor DP, C-terminal

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006357	Biological Process	regulation of transcription from RNA polymerase II promoter
GO:0007049	Biological Process	cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0000981	Molecular Function	RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677	Molecular Function	DNA binding
GO:0005515	Molecular Function	protein binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000084	anatomy	plant sperm cell
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 292 aa Download sequence Send to blast
MSMEMELFVT PEKQRQHPSV SVEKTPVRRK LIVDDDSEIG SEKKGQSRTS GGGLRQFSVM 60 VCQKLEAKKI TTYKEVADEI ISDFATIKQN AEKPLNENEY NEKNIRRRVY DALNVFMALD 120 IIARDKKEIR WKGLPITCKK DVEEVKMDRN KVMSSVQKKA AFLKELREKV SSLESLMSRN 180 QEMVVKTQGP AEGFTLPFIL LETNPHAVVE IEISEDMQLV HLDFNSTPFS VHDDAYILKL 240 MQEQKQEQNR VSSSSSTHHQ SQHSSAHSSS SSCIASGTSG PVCWNSGSID TR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_B	8e-26	43	135	3	90	PROTEIN (TRANSCRIPTION FACTOR DP-2)
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.4941	0.0	bud\| flower\| seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	11125650	0.0
Genevisible	251052_at	0.0
Expression Atlas	AT5G02470	-
AtGenExpress	AT5G02470	-
ATTED-II	AT5G02470	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Low expression at the G1/S transition and increases during the S phase. S/G2 transitions. {ECO:0000269\|PubMed:11669580}.
Uniprot	TISSUE SPECIFICITY: Strongly expressed in the actively dividing tissues of the shoot apical meristem, young leaf primordia, the vascular tissues of the maturing leaf primordia and axillary buds. {ECO:0000269\|PubMed:11889041}.

Functional Description ? help Back to Top
Source	Description
TAIR	core cell cycle genes
UniProt	Involved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specific genes. {ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT5G02470.3

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by the transcription factor ERF114. {ECO:0000269\|PubMed:23616605}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT2G29680(A), AT3G54180(A)

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT5G22220, AT1G47870
IntAct	Search Q9FNY3

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT5G02470

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AJ319027	0.0	AJ319027.1 Arabidopsis thaliana partial mRNA for E2F dimerisation partner protein (dp2a gene).
GenBank	AK117135	0.0	AK117135.1 Arabidopsis thaliana At5g02470 mRNA for putative DP-2 transcription factor, complete cds, clone: RAFL16-67-D16.
GenBank	BT005286	0.0	BT005286.1 Arabidopsis thaliana At5g02470 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_195867.2	0.0	Transcription factor DP
Refseq	NP_851027.1	0.0	Transcription factor DP
Refseq	NP_851028.1	0.0	Transcription factor DP
Swissprot	Q9FNY3	0.0	DPA_ARATH; Transcription factor-like protein DPA
TrEMBL	A0A178ULD9	0.0	A0A178ULD9_ARATH; DPA
STRING	AT5G02470.2	0.0	(Arabidopsis thaliana)

Link Out ? help Back to Top
Phytozome	AT5G02470.3
Entrez Gene	830987
iHOP	AT5G02470
wikigenes	AT5G02470

Publications ? help Back to Top
Magyar Z,Atanassova A,De Veylder L,Rombauts S,Inzé D Characterization of two distinct DP-related genes from Arabidopsis thaliana. FEBS Lett., 2000. 486(1): p. 79-87 [PMID:11108847] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] de Jager SM,Menges M,Bauer UM,Murra JA Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities. Plant Mol. Biol., 2001. 47(4): p. 555-68 [PMID:11669580] Mariconti L, et al. The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants. J. Biol. Chem., 2002. 277(12): p. 9911-9 [PMID:11786543] Kosugi S,Ohashi Y E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form. J. Biol. Chem., 2002. 277(19): p. 16553-8 [PMID:11867638] De Veylder L, et al. Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO J., 2002. 21(6): p. 1360-8 [PMID:11889041] Kosugi S,Ohashi Y Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation. Plant Physiol., 2002. 128(3): p. 833-43 [PMID:11891240] Seki M, et al. Functional annotation of a full-length Arabidopsis cDNA collection. Science, 2002. 296(5565): p. 141-5 [PMID:11910074] Kosugi S,Ohashi Y E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters. Plant J., 2002. 29(1): p. 45-59 [PMID:12060226] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Vlieghe K, et al. The DP-E2F-like gene DEL1 controls the endocycle in Arabidopsis thaliana. Curr. Biol., 2005. 15(1): p. 59-63 [PMID:15649366] Magyar Z, et al. The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division. Plant Cell, 2005. 17(9): p. 2527-41 [PMID:16055635] Vandepoele K, et al. Genome-wide identification of potential plant E2F target genes. Plant Physiol., 2005. 139(1): p. 316-28 [PMID:16126853] Yoshizumi T, et al. Increased level of polyploidy1, a conserved repressor of CYCLINA2 transcription, controls endoreduplication in Arabidopsis. Plant Cell, 2006. 18(10): p. 2452-68 [PMID:17012601] Gusti A, et al. The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development. PLoS ONE, 2009. 4(3): p. e4780 [PMID:19277118] Boruc J, et al. Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network. Plant Cell, 2010. 22(4): p. 1264-80 [PMID:20407024] Henriques R, et al. Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1-E2F pathway activity. EMBO J., 2010. 29(17): p. 2979-93 [PMID:20683442] Van Leene J, et al. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Mol. Syst. Biol., 2010. 6: p. 397 [PMID:20706207] Elrouby N,Coupland G Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Proc. Natl. Acad. Sci. U.S.A., 2010. 107(40): p. 17415-20 [PMID:20855607] Arabidopsis Interactome Mapping Consortium Evidence for network evolution in an Arabidopsis interactome map. Science, 2011. 333(6042): p. 601-7 [PMID:21798944] Efroni I, et al. Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses. Dev. Cell, 2013. 24(4): p. 438-45 [PMID:23449474] Mehrnia M,Balazadeh S,Zanor MI,Mueller-Roeber B EBE, an AP2/ERF transcription factor highly expressed in proliferating cells, affects shoot architecture in Arabidopsis. Plant Physiol., 2013. 162(2): p. 842-57 [PMID:23616605] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178]