PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT4G36060.1

Common Name

bHLH11, EN137, T19K4.190

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

bHLH

Protein Properties

Length: 286aa MW: 31784.5 Da PI: 5.9904

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G36060.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	21.3	4.7e-07	49	93	5	53
HHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHH CS HLH 5 hnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIks 53 + erE+ RRd++++ f eL l ++ +K +Ka++L+ +++ +k+ AT4G36060.1 49 KAEREKLRRDKLKEQFLELGNALDPN----RPKSDKASVLTDTIQMLKD 93 689******************997....79**********99885 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	11.255	44	94	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	9.16E-13	44	114	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	3.6E-11	48	115	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	9.9E-5	48	93	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	1.1E-5	50	100	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	0.00101	51	98	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0009507	Cellular Component	chloroplast
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0046983	Molecular Function	protein dimerization activity

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000293	anatomy	guard cell

Sequence ? help Back to Top
Protein Sequence Length: 286 aa Download sequence Send to blast
MDQPMKPKTC SESDFADDSS ASSSSSSGQN LRGAEMVVEV KKEAVCSQKA EREKLRRDKL 60 KEQFLELGNA LDPNRPKSDK ASVLTDTIQM LKDVMNQVDR LKAEYETLSQ ESRELIQEKS 120 ELREEKATLK SDIEILNAQY QHRIKTMVPW VPHYSYHIPF VAITQGQSSF IPYSASVNPL 180 TEQQASVQQH SSSSADASMK QDSKIKPLDL DLMMNSNHSG QGNDQKDDVR LKLELKIHAS 240 SLAQQDVSGK EKKVSLTTTA SSSNSYSLSQ AVQDSSPGTV NDMLKP

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	22329203	0.0
Genevisible	253127_at	1e-135
Expression Atlas	AT4G36060	-
AtGenExpress	AT4G36060	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed consitutively in roots, leaves, stems, and flowers. {ECO:0000269\|PubMed:12679534}.

Function -- GeneRIF ? help Back to Top
bHLH11 expression levels were high in the roots and up-regulated after plants were transferred to Fe sufficient conditions. Although T-DNA knockout mutants of bHLH11 were lethal, dominant negative (DN-) and overexpression (OX-) of bHLH11 plants exhibited sensitivity to Fe deficiency. [PMID: 30417276]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G36060.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G14920
IntAct	Search Q8W2F2

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G36060

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF251696	0.0	AF251696.2 Arabidopsis thaliana putative transcription factor BHLH11 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_849566.1	0.0	basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Swissprot	Q8W2F2	0.0	BH011_ARATH; Transcription factor bHLH11
TrEMBL	C0SVL7	0.0	C0SVL7_ARATH; Uncharacterized protein At4g36060 (Fragment)
STRING	AT4G36060.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2353	27	62
Representative plant	OGRP3401	14	25

Link Out ? help Back to Top
Phytozome	AT4G36060.1
Entrez Gene	829762
iHOP	AT4G36060
wikigenes	AT4G36060

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Heim MA, et al. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol. Biol. Evol., 2003. 20(5): p. 735-47 [PMID:12679534] Toledo-Ortiz G,Huq E,Quail PH The Arabidopsis basic/helix-loop-helix transcription factor family. Plant Cell, 2003. 15(8): p. 1749-70 [PMID:12897250] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Bailey PC, et al. Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. Plant Cell, 2003. 15(11): p. 2497-502 [PMID:14600211] Kleffmann T, et al. The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions. Curr. Biol., 2004. 14(5): p. 354-62 [PMID:15028209] Koroleva OA,Tomlinson ML,Leader D,Shaw P,Doonan JH High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions. Plant J., 2005. 41(1): p. 162-74 [PMID:15610358] Kawabe A,Hansson B,Forrest A,Hagenblad J,Charlesworth D Comparative gene mapping in Arabidopsis lyrata chromosomes 6 and 7 and A. thaliana chromosome IV: evolutionary history, rearrangements and local recombination rates. Genet. Res., 2006. 88(1): p. 45-56 [PMID:17014743] Krishnaswamy SS, et al. Transcriptional profiling of pea ABR17 mediated changes in gene expression in Arabidopsis thaliana. BMC Plant Biol., 2008. 8: p. 91 [PMID:18783601] Jaspers P, et al. Unequally redundant RCD1 and SRO1 mediate stress and developmental responses and interact with transcription factors. Plant J., 2009. 60(2): p. 268-79 [PMID:19548978] Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Long TA, et al. The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. Plant Cell, 2010. 22(7): p. 2219-36 [PMID:20675571] Hanada K, et al. Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana. Mol. Biol. Evol., 2011. 28(1): p. 377-82 [PMID:20736450] Mar Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners. Plant Physiol., 2014. 166(2): p. 1022-32 [PMID:25118255] Ezer D, et al. The G-Box Transcriptional Regulatory Code in Arabidopsis. Plant Physiol., 2017. 175(2): p. 628-640 [PMID:28864470] Min JH, et al. Arabidopsis Basic Helix-Loop-Helix 34 (bHLH34) Is Involved in Glucose Signaling through Binding to a GAGA Cis-Element. Front Plant Sci, 2017. 8: p. 2100 [PMID:29321786] Tanabe N, et al. The basic helix-loop-helix transcription factor, bHLH11 functions in the iron-uptake system in Arabidopsis thaliana. J. Plant Res., 2019. 132(1): p. 93-105 [PMID:30417276]