PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT4G33880.1

Common Name

BHLH85, EN115, F17I5.70, RSL2

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

bHLH

Protein Properties

Length: 352aa MW: 38770.4 Da PI: 4.5879

Description

ROOT HAIR DEFECTIVE 6-LIKE 2

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G33880.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	31.9	2.4e-10	282	322	10	55
HHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 10 rrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 r+RR+riN+++ L+ l+P+ +K++ +++Le+Av+Y+k Lq AT4G33880.1 282 RKRRERINERLRILQNLVPNG-----TKVDISTMLEEAVHYVKFLQ 322 9****************97.....8****************9 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	14.85	272	321	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	5.89E-14	274	338	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	4.8E-12	277	331	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	4.1E-11	278	327	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	1.44E-11	281	326	No hit	No description
Pfam	PF00010	1.4E-7	282	322	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009733	Biological Process	response to auxin
GO:0016049	Biological Process	cell growth
GO:0045944	Biological Process	positive regulation of transcription from RNA polymerase II promoter
GO:0048766	Biological Process	root hair initiation
GO:0005634	Cellular Component	nucleus
GO:0001046	Molecular Function	core promoter sequence-specific DNA binding
GO:0001228	Molecular Function	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 352 aa Download sequence Send to blast
MEAMGEWSNN LGGMYTYATE EADFMNQLLA SYDHPGTGSS SGAAASGDHQ GLYWNLGSHH 60 NHLSLVSEAG SFCFSQESSS YSAGNSGYYT VVPPTVEENQ NETMDFGMED VTINTNSYLV 120 GEETSECDVE KYSSGKTLMP LETVVENHDD EESLLQSEIS VTTTKSLTGS KKRSRATSTD 180 KNKRARVNKR AQKNVEMSGD NNEGEEEEGE TKLKKRKNGA MMSRQNSSTT FCTEEESNCA 240 DQDGGGEDSS SKEDDPSKAL NLNGKTRASR GAATDPQSLY ARKRRERINE RLRILQNLVP 300 NGTKVDISTM LEEAVHYVKF LQLQIKLLSS DDLWMYAPIA FNGMDIGLSS PR

Sequence ? help Back to Top

Protein Sequence Length: 352 aa Download sequence Send to blast

MEAMGEWSNN LGGMYTYATE EADFMNQLLA SYDHPGTGSS SGAAASGDHQ GLYWNLGSHH  60
NHLSLVSEAG SFCFSQESSS YSAGNSGYYT VVPPTVEENQ NETMDFGMED VTINTNSYLV  120
GEETSECDVE KYSSGKTLMP LETVVENHDD EESLLQSEIS VTTTKSLTGS KKRSRATSTD  180
KNKRARVNKR AQKNVEMSGD NNEGEEEEGE TKLKKRKNGA MMSRQNSSTT FCTEEESNCA  240
DQDGGGEDSS SKEDDPSKAL NLNGKTRASR GAATDPQSLY ARKRRERINE RLRILQNLVP  300
NGTKVDISTM LEEAVHYVKF LQLQIKLLSS DDLWMYAPIA FNGMDIGLSS PR

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.31542	0.0	root

Expression -- Microarray ? help Back to Top
Source	ID
Expression Atlas	AT4G33880
AtGenExpress	AT4G33880

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Roots. {ECO:0000269\|PubMed:12679534}.

Functional Description ? help Back to Top
Source	Description
TAIR	RSL2 was expressed concurrently with RSL4 and its expression was controlled by RHD6 and RSL1. Required for root-hair growth.

Function -- GeneRIF ? help Back to Top
Results suggest that OBF BINDING PROTEIN4 (OBP4)-mediated transcriptional repression of ROOT HAIR DEFECTIVE6-LIKE2 (RSL2) promoter to repress RSL2 contributes to the abscisic acid (ABA)-dependent inhibition of root hair growth. [PMID: 28167701]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G33880.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By jasmonic acid (JA) treatment. {ECO:0000269\|PubMed:12679534}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G33880

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK228110	0.0	AK228110.1 Arabidopsis thaliana mRNA for putative bHLH transcription factor, complete cds, clone: RAFL14-58-P18.
GenBank	BT003137	0.0	BT003137.1 Arabidopsis thaliana At4g33880 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_195114.2	0.0	ROOT HAIR DEFECTIVE 6-LIKE 2
Swissprot	Q84WK0	0.0	BH085_ARATH; Transcription factor bHLH85
TrEMBL	A0A178V243	0.0	A0A178V243_ARATH; RSL2
STRING	AT4G33880.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2834	26	63
Representative plant	OGRP1048	14	54

Link Out ? help Back to Top
Phytozome	AT4G33880.1
Entrez Gene	829531
iHOP	AT4G33880
wikigenes	AT4G33880

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Heim MA, et al. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol. Biol. Evol., 2003. 20(5): p. 735-47 [PMID:12679534] Toledo-Ortiz G,Huq E,Quail PH The Arabidopsis basic/helix-loop-helix transcription factor family. Plant Cell, 2003. 15(8): p. 1749-70 [PMID:12897250] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Bailey PC, et al. Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. Plant Cell, 2003. 15(11): p. 2497-502 [PMID:14600211] Czechowski T,Bari RP,Stitt M,Scheible WR,Udvardi MK Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: unprecedented sensitivity reveals novel root- and shoot-specific genes. Plant J., 2004. 38(2): p. 366-79 [PMID:15078338] Yi K,Menand B,Bell E,Dolan L A basic helix-loop-helix transcription factor controls cell growth and size in root hairs. Nat. Genet., 2010. 42(3): p. 264-7 [PMID:20139979] Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Efroni I, et al. Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses. Dev. Cell, 2013. 24(4): p. 438-45 [PMID:23449474] Rymen B, et al. ABA Suppresses Root Hair Growth via the OBP4 Transcriptional Regulator. Plant Physiol., 2017. 173(3): p. 1750-1762 [PMID:28167701] Han H, et al. Altered expression of the TaRSL2 gene contributed to variation in root hair length during allopolyploid wheat evolution. Planta, 2017. 246(5): p. 1019-1028 [PMID:28770336]