PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT4G17490.1

Common Name

ATERF6, dl4780c, ERF103, ERF6, ERF-6, ERF-6-6, FCAALL.120

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

ERF

Protein Properties

Length: 282aa MW: 32108.3 Da PI: 4.9266

Description

ethylene responsive element binding factor 6

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G17490.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	56.8	5.4e-18	136	186	2	55
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 +y+GVr ++ +g+++AeIrdp+ +g +r++lg+f ta eAa+a+++ + +l+g AT4G17490.1 136 HYRGVRMRP-WGKFAAEIRDPTRRG--TRVWLGTFETAIEAARAYDKEAFRLRG 186 7******.******97665..***********************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.730.10	1.5E-31	135	195	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	23.406	136	194	IPR001471	AP2/ERF domain
SuperFamily	SSF54171	5.95E-22	136	196	IPR016177	DNA-binding domain
Pfam	PF00847	2.3E-11	136	186	IPR001471	AP2/ERF domain
CDD	cd00018	3.42E-29	136	194	No hit	No description
SMART	SM00380	1.1E-34	136	200	IPR001471	AP2/ERF domain
PRINTS	PR00367	2.2E-10	137	148	IPR001471	AP2/ERF domain
PRINTS	PR00367	2.2E-10	160	176	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000302	Biological Process	response to reactive oxygen species
GO:0001944	Biological Process	vasculature development
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0006952	Biological Process	defense response
GO:0009644	Biological Process	response to high light intensity
GO:0009873	Biological Process	ethylene-activated signaling pathway
GO:0010200	Biological Process	response to chitin
GO:0051301	Biological Process	cell division
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0005515	Molecular Function	protein binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000037	anatomy	shoot apex
PO:0000084	anatomy	plant sperm cell
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 282 aa Download sequence Send to blast
MATPNEVSAL FLIKKYLLDE LSPLPTTATT NRWMNDFTSF DQTGFEFSEF ETKPEIIDLV 60 TPKPEIFDFD VKSEIPSESN DSFTFQSNPP RVTVQSNRKP PLKIAPPNRT KWIQFATGNP 120 KPELPVPVVA AEEKRHYRGV RMRPWGKFAA EIRDPTRRGT RVWLGTFETA IEAARAYDKE 180 AFRLRGSKAI LNFPLEVDKW NPRAEDGRGL YNKRKRDGEE EEVTVVEKVL KTEESYDVSG 240 GENVESGLTA IDDWDLTEFL SMPLLSPLSP HPPFGYPQLT VV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2gcc_A	5e-29	135	198	4	67	ATERF1
3gcc_A	5e-29	135	198	4	67	ATERF1
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.24407	0.0	root\| seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30684062	0.0
Genevisible	245250_at	0.0
Expression Atlas	AT4G17490	-
AtGenExpress	AT4G17490	-
ATTED-II	AT4G17490	-

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes a member of the ERF (ethylene response factor) subfamily B-3 of ERF/AP2 transcription factor family (ATERF-6). The protein contains one AP2 domain. There are 18 members in this subfamily including ATERF-1, ATERF-2, AND ATERF-5.
UniProt	Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250, ECO:0000269\|PubMed:9756931}.

Function -- GeneRIF ? help Back to Top
Reduced inducibilty in ERF6 constitutive overexepressors was consistent with suppression of SA-mediated signalling, as was an increased susceptibility to avirulent Pseudomonas syringae. [PMID: 22563431] These data might provide new insight into the mechanisms that regulate reactive oxygen species-responsive gene transcription via a complex of MPK6, ERF6, and the ROSE7/GCC box under oxidative stress. [PMID: 23300166] ERF6, a substrate of MPK3 and MPK6, plays important roles downstream of the MPK3/MPK6 cascade in regulating plant defense against fungal pathogens. [PMID: 23524660] ERF5 and ERF6 form a missing link between the previously observed stress-induced 1-aminocyclopropane-1-carboxylic acid accumulation and DELLA-mediated cell cycle exit and execute a dual role by regulating both stress tolerance and growth inhibition. [PMID: 23553636] Results indicate that ERF6 plays an important role as a positive antioxidant regulator during plant growth and in response to biotic and abiotic stresses. [PMID: 23940555] Our data demonstrate that dynamic mechanisms exist to fine-tune the stress response and that ERF11 counteracts ERF6 to maintain a balance between plant growth and stress defense. [PMID: 25995327] Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity. [PMID: 27081184]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00437	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G17490.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G32640 (R)

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	ethylene

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G17490

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AL161546	0.0	AL161546.2 Arabidopsis thaliana DNA chromosome 4, contig fragment No. 46.
GenBank	CP002687	0.0	CP002687.1 Arabidopsis thaliana chromosome 4 sequence.
GenBank	Z97343	0.0	Z97343.1 Arabidopsis thaliana DNA chromosome 4, ESSA I FCA contig fragment No. 8.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_567529.1	0.0	ethylene responsive element binding factor 6
Swissprot	Q8VZ91	0.0	EF103_ARATH; Ethylene-responsive transcription factor 6
TrEMBL	A0A178UUL9	0.0	A0A178UUL9_ARATH; ERF6
STRING	AT4G17490.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM10	28	1650
Representative plant	OGRP6	16	1718

Link Out ? help Back to Top
Phytozome	AT4G17490.1
Entrez Gene	827463
iHOP	AT4G17490
wikigenes	AT4G17490

Publications ? help Back to Top
Durrant WE,Rowland O,Piedras P,Hammond-Kosack KE,Jones JD cDNA-AFLP reveals a striking overlap in race-specific resistance and wound response gene expression profiles. Plant Cell, 2000. 12(6): p. 963-77 [PMID:10852940] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Menges M,Hennig L,Gruissem W,Murray JA Cell cycle-regulated gene expression in Arabidopsis. J. Biol. Chem., 2002. 277(44): p. 41987-2002 [PMID:12169696] Forsbach A,Schubert D,Lechtenberg B,Gils M,Schmidt R A comprehensive characterization of single-copy T-DNA insertions in the Arabidopsis thaliana genome. Plant Mol. Biol., 2003. 52(1): p. 161-76 [PMID:12825697] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Goda H, et al. Comprehensive comparison of auxin-regulated and brassinosteroid-regulated genes in Arabidopsis. Plant Physiol., 2004. 134(4): p. 1555-73 [PMID:15047898] Navarro L, et al. The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis. Plant Physiol., 2004. 135(2): p. 1113-28 [PMID:15181213] Teige M, et al. The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis. Mol. Cell, 2004. 15(1): p. 141-52 [PMID:15225555] Guan Y,Nothnagel EA Binding of arabinogalactan proteins by Yariv phenylglycoside triggers wound-like responses in Arabidopsis cell cultures. Plant Physiol., 2004. 135(3): p. 1346-66 [PMID:15235117] Scheible WR, et al. Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen. Plant Physiol., 2004. 136(1): p. 2483-99 [PMID:15375205] Chang S,Pikaard CS Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. J. Biol. Chem., 2005. 280(1): p. 796-804 [PMID:15516340] Danon A,Miersch O,Felix G,Camp RG,Apel K Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana. Plant J., 2005. 41(1): p. 68-80 [PMID:15610350] Stanley Kim H, et al. Transcriptional divergence of the duplicated oxidative stress-responsive genes in the Arabidopsis genome. Plant J., 2005. 41(2): p. 212-20 [PMID:15634198] Cominelli E, et al. A guard-cell-specific MYB transcription factor regulates stomatal movements and plant drought tolerance. Curr. Biol., 2005. 15(13): p. 1196-200 [PMID:16005291] Lee BH,Henderson DA,Zhu JK The Arabidopsis cold-responsive transcriptome and its regulation by ICE1. Plant Cell, 2005. 17(11): p. 3155-75 [PMID:16214899] Suzuki N, et al. Enhanced tolerance to environmental stress in transgenic plants expressing the transcriptional coactivator multiprotein bridging factor 1c. Plant Physiol., 2005. 139(3): p. 1313-22 [PMID:16244138] Raghavan C,Ong EK,Dalling MJ,Stevenson TW Regulation of genes associated with auxin, ethylene and ABA pathways by 2,4-dichlorophenoxyacetic acid in Arabidopsis. Funct. Integr. Genomics, 2006. 6(1): p. 60-70 [PMID:16317577] Nakano T,Suzuki K,Fujimura T,Shinshi H Genome-wide analysis of the ERF gene family in Arabidopsis and rice. Plant Physiol., 2006. 140(2): p. 411-32 [PMID:16407444] Laskowski M,Biller S,Stanley K,Kajstura T,Prusty R Expression profiling of auxin-treated Arabidopsis roots: toward a molecular analysis of lateral root emergence. Plant Cell Physiol., 2006. 47(6): p. 788-92 [PMID:16621846] Town CD, et al. Comparative genomics of Brassica oleracea and Arabidopsis thaliana reveal gene loss, fragmentation, and dispersal after polyploidy. Plant Cell, 2006. 18(6): p. 1348-59 [PMID:16632643] AbuQamar S, et al. Expression profiling and mutant analysis reveals complex regulatory networks involved in Arabidopsis response to Botrytis infection. Plant J., 2006. 48(1): p. 28-44 [PMID:16925600] Jung J, et al. The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis. Planta, 2007. 225(3): p. 575-88 [PMID:16937017] Xin Z,Mandaokar A,Chen J,Last RL,Browse J Arabidopsis ESK1 encodes a novel regulator of freezing tolerance. Plant J., 2007. 49(5): p. 786-99 [PMID:17316173] Ma S,Bohnert HJ Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression. Genome Biol., 2007. 8(4): p. R49 [PMID:17408486] Dombrecht B, et al. MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis. Plant Cell, 2007. 19(7): p. 2225-45 [PMID:17616737] Libault M,Wan J,Czechowski T,Udvardi M,Stacey G Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor. Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11 [PMID:17722694] Ferreira FJ,Guo C,Coleman JR Reduction of plastid-localized carbonic anhydrase activity results in reduced Arabidopsis seedling survivorship. Plant Physiol., 2008. 147(2): p. 585-94 [PMID:18434607] Hu J, et al. Transcriptional responses of Arabidopsis thaliana during wilt disease caused by the soil-borne phytopathogenic bacterium, Ralstonia solanacearum. PLoS ONE, 2008. 3(7): p. e2589 [PMID:18596930] Xu J, et al. Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis. J. Biol. Chem., 2008. 283(40): p. 26996-7006 [PMID:18693252] Son GH, et al. Ethylene-responsive element-binding factor 5, ERF5, is involved in chitin-induced innate immunity response. Mol. Plant Microbe Interact., 2012. 25(1): p. 48-60 [PMID:21936663] Moffat CS, et al. ERF5 and ERF6 play redundant roles as positive regulators of JA/Et-mediated defense against Botrytis cinerea in Arabidopsis. PLoS ONE, 2012. 7(4): p. e35995 [PMID:22563431] Etchells JP,Provost CM,Turner SR Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling. PLoS Genet., 2012. 8(11): p. e1002997 [PMID:23166504] Wang P,Du Y,Zhao X,Miao Y,Song CP The MPK6-ERF6-ROS-responsive cis-acting Element7/GCC box complex modulates oxidative gene transcription and the oxidative response in Arabidopsis. Plant Physiol., 2013. 161(3): p. 1392-408 [PMID:23300166] Meng X, et al. Phosphorylation of an ERF transcription factor by Arabidopsis MPK3/MPK6 regulates plant defense gene induction and fungal resistance. Plant Cell, 2013. 25(3): p. 1126-42 [PMID:23524660] Dubois M, et al. Ethylene Response Factor6 acts as a central regulator of leaf growth under water-limiting conditions in Arabidopsis. Plant Physiol., 2013. 162(1): p. 319-32 [PMID:23553636] Sewelam N, et al. Ethylene response factor 6 is a regulator of reactive oxygen species signaling in Arabidopsis. PLoS ONE, 2013. 8(8): p. e70289 [PMID:23940555] Dubois M, et al. The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 Antagonistically Regulate Mannitol-Induced Growth Inhibition in Arabidopsis. Plant Physiol., 2015. 169(1): p. 166-79 [PMID:25995327] Xu J, et al. Pathogen-Responsive MPK3 and MPK6 Reprogram the Biosynthesis of Indole Glucosinolates and Their Derivatives in Arabidopsis Immunity. Plant Cell, 2016. 28(5): p. 1144-62 [PMID:27081184] Riechmann JL,Meyerowitz EM The AP2/EREBP family of plant transcription factors. Biol. Chem., 1998. 379(6): p. 633-46 [PMID:9687012] Hao D,Ohme-Takagi M,Sarai A Unique mode of GCC box recognition by the DNA-binding domain of ethylene-responsive element-binding factor (ERF domain) in plant. J. Biol. Chem., 1998. 273(41): p. 26857-61 [PMID:9756931]