PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G46510.1
Common NameAIB, ATAIB, BHLH17, EN35, F13A10.4, JAM1
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 566aa    MW: 63305 Da    PI: 5.3323
Description ABA-inducible BHLH-type transcription factor
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G46510.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH43.75e-14395441455
                  HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                  +h e+Er+RR+++N++f  Lr+++P+ +      K++Ka+ L  A+ YIk+Lq
  AT2G46510.1 395 NHVEAERQRREKLNQRFYALRSVVPNiS------KMDKASLLGDAISYIKELQ 441
                  799***********************66......******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.3E-5148239IPR025610Transcription factor MYC/MYB N-terminal
SuperFamilySSF474594.97E-19390453IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088817.936391440IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000839.99E-16394445No hitNo description
Gene3DG3DSA:4.10.280.101.1E-18395454IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.9E-11395441IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003536.3E-18397446IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009611Biological Processresponse to wounding
GO:0009737Biological Processresponse to abscisic acid
GO:0009738Biological Processabscisic acid-activated signaling pathway
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000025anatomyroot tip
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000252anatomyendodermis
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0009062anatomygynoecium
PO:0009066anatomyanther
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020127anatomyprimary root
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 566 aa     Download sequence    Send to blast
MNMSDLGWDD EDKSVVSAVL GHLASDFLRA NSNSNQNLFL VMGTDDTLNK KLSSLVDWPN  60
SENFSWNYAI FWQQTMSRSG QQVLGWGDGC CREPNEEEES KVVRSYNFNN MGAEEETWQD  120
MRKRVLQKLH RLFGGSDEDN YALSLEKVTA TEIFFLASMY FFFNHGEGGP GRCYSSGKHV  180
WLSDAVNSES DYCFRSFMAK SAGIRTIVMV PTDAGVLELG SVWSLPENIG LVKSVQALFM  240
RRVTQPVMVT SNTNMTGGIH KLFGQDLSGA HAYPKKLEVR RNLDERFTPQ SWEGYNNNKG  300
PTFGYTPQRD DVKVLENVNM VVDNNNYKTQ IEFAGSSVAA SSNPSTNTQQ EKSESCTEKR  360
PVSLLAGAGI VSVVDEKRPR KRGRKPANGR EEPLNHVEAE RQRREKLNQR FYALRSVVPN  420
ISKMDKASLL GDAISYIKEL QEKVKIMEDE RVGTDKSLSE SNTITVEESP EVDIQAMNEE  480
VVVRVISPLD SHPASRIIQA MRNSNVSLME AKLSLAEDTM FHTFVIKSNN GSDPLTKEKL  540
IAAFYPETSS TQPPLPSSSS QVSGDI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A1e-28389460273Transcription factor MYC2
5gnj_B1e-28389460273Transcription factor MYC2
5gnj_E1e-28389460273Transcription factor MYC2
5gnj_F1e-28389460273Transcription factor MYC2
5gnj_G1e-28389460273Transcription factor MYC2
5gnj_I1e-28389460273Transcription factor MYC2
5gnj_M1e-28389460273Transcription factor MYC2
5gnj_N1e-28389460273Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1376384KRPRKRGRK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.198720.0flower| leaf| silique
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306904170.0
Genevisible265452_at0.0
Expression AtlasAT2G46510-
AtGenExpressAT2G46510-
ATTED-IIAT2G46510-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: In seedlings, mainly expressed in root tips, cotyledons, hypocotyls, and leaves, as well as its guard cells. In adult plant, detectable in stems, flowers, and siliques. {ECO:0000269|PubMed:17828375}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a nuclear localized BLH domain containing transcriptional activator involved in response to ABA. Overexpression confers enhanced ABA responsiveness while loss of function mutants are ABA sensitive.
UniProtTranscription activator. Regulates positively abscisic acid (ABA) response. Confers drought tolerance and sensitivity to ABA. {ECO:0000269|PubMed:17828375}.
Function -- GeneRIF ? help Back to Top
  1. AtAIB functions as a transcription activator involved in the regulation of ABA signaling in Arabidopsis.
    [PMID: 17828375]
  2. A few genes having either WRKY or bHLH cis elements in their promoter regions showed higher transcript levels than wild type.
    [PMID: 22948308]
  3. Data indicate that JAM1 (AT2G46510) and MYC2 competitively bind to the target sequence of MYC2, which likely provides the mechanism for negative regulation of jasmonates (JAs) signaling and suppression of MYC2 functions by JAM1.
    [PMID: 23673982]
  4. JAM1 (At2g46510) negatively regulates the JA response in a manner that is mostly antagonistic to MYC2.
    [PMID: 23852442]
  5. These results suggest that JAM1, JAM2, and JAM3 act redundantly as negative regulators of jasmonic acid-mediated male fertility.[JAM1]
    [PMID: 24056034]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00101PBM26531826Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G46510.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Transiently by ABA and polyethylene glycol (PEG). {ECO:0000269|PubMed:17828375}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G46510
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0064180.0AC006418.4 Arabidopsis thaliana chromosome 2 clone F13A10 map CIC06C03, complete sequence.
GenBankAC0065260.0AC006526.8 Arabidopsis thaliana chromosome 2 clone F11C10 map CIC02E07, complete sequence.
GenBankCP0026850.0CP002685.1 Arabidopsis thaliana chromosome 2, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_566078.10.0ABA-inducible BHLH-type transcription factor
SwissprotQ9ZPY80.0AIB_ARATH; Transcription factor ABA-INDUCIBLE bHLH-TYPE
TrEMBLA0A178VP130.0A0A178VP13_ARATH; JAM1
STRINGAT2G46510.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM37582759
Representative plantOGRP25311123
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Hoth S, et al.
    Genome-wide gene expression profiling in Arabidopsis thaliana reveals new targets of abscisic acid and largely impaired gene regulation in the abi1-1 mutant.
    J. Cell. Sci., 2002. 115(Pt 24): p. 4891-900
    [PMID:12432076]
  3. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  4. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  5. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  6. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  7. Truman W,de Zabala MT,Grant M
    Type III effectors orchestrate a complex interplay between transcriptional networks to modify basal defence responses during pathogenesis and resistance.
    Plant J., 2006. 46(1): p. 14-33
    [PMID:16553893]
  8. Mandaokar A, et al.
    Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling.
    Plant J., 2006. 46(6): p. 984-1008
    [PMID:16805732]
  9. Yan Y, et al.
    A downstream mediator in the growth repression limb of the jasmonate pathway.
    Plant Cell, 2007. 19(8): p. 2470-83
    [PMID:17675405]
  10. Li H, et al.
    The bHLH-type transcription factor AtAIB positively regulates ABA response in Arabidopsis.
    Plant Mol. Biol., 2007. 65(5): p. 655-65
    [PMID:17828375]
  11. Tominaga-Wada R,Iwata M,Nukumizu Y,Wada T
    Analysis of IIId, IIIe and IVa group basic-helix-loop-helix proteins expressed in Arabidopsis root epidermis.
    Plant Sci., 2011. 181(4): p. 471-8
    [PMID:21889054]
  12. Cui H, et al.
    Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis.
    Plant Physiol., 2011. 157(3): p. 1221-31
    [PMID:21951467]
  13. Babitha KC, et al.
    Co-expression of AtbHLH17 and AtWRKY28 confers resistance to abiotic stress in Arabidopsis.
    Transgenic Res., 2013. 22(2): p. 327-41
    [PMID:22948308]
  14. Nakata M, et al.
    A bHLH-type transcription factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, acts as a repressor to negatively regulate jasmonate signaling in arabidopsis.
    Plant Cell, 2013. 25(5): p. 1641-56
    [PMID:23673982]
  15. Sasaki-Sekimoto Y, et al.
    Basic helix-loop-helix transcription factors JASMONATE-ASSOCIATED MYC2-LIKE1 (JAM1), JAM2, and JAM3 are negative regulators of jasmonate responses in Arabidopsis.
    Plant Physiol., 2013. 163(1): p. 291-304
    [PMID:23852442]
  16. Song S, et al.
    The bHLH subgroup IIId factors negatively regulate jasmonate-mediated plant defense and development.
    PLoS Genet., 2013. 9(7): p. e1003653
    [PMID:23935516]
  17. Nakata M,Ohme-Takagi M
    Two bHLH-type transcription factors, JA-ASSOCIATED MYC2-LIKE2 and JAM3, are transcriptional repressors and affect male fertility.
    Plant Signal Behav, 2013. 8(12): p. e26473
    [PMID:24056034]
  18. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  19. Sasaki-Sekimoto Y,Saito H,Masuda S,Shirasu K,Ohta H
    Comprehensive analysis of protein interactions between JAZ proteins and bHLH transcription factors that negatively regulate jasmonate signaling.
    Plant Signal Behav, 2014. 9(1): p. e27639
    [PMID:24394987]
  20. Fonseca S, et al.
    bHLH003, bHLH013 and bHLH017 are new targets of JAZ repressors negatively regulating JA responses.
    PLoS ONE, 2014. 9(1): p. e86182
    [PMID:24465948]
  21. Thatcher LF, et al.
    Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum.
    J. Exp. Bot., 2016. 67(8): p. 2367-86
    [PMID:26896849]
  22. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]