PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G42300.1
Common NameBHLH48, EN97, MHK10.2
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 327aa    MW: 36192.4 Da    PI: 6.4428
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G42300.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH26.21.4e-08195242455
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                  +h+ +Er RR++iN ++  L+el+P +    +k    a +L + +++++ Lq
  AT2G42300.1 195 NHSLAERARREKINARMKLLQELVPGC----DKIQGTALVLDEIINHVQTLQ 242
                  79************************9....788999999999999999998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474592.09E-15189260IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.08E-9189246No hitNo description
PROSITE profilePS5088814.342191241IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.105.9E-15191259IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.9E-6195242IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003539.4E-8197247IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 327 aa     Download sequence    Send to blast
MDLTQGFRAR SGVVGPVAGL ESLNFSDEFR HLVTTMPPET TGGSFTALLE MPVTQAMELL  60
HFPDSSSSQA RTVTSGDISP TTLHPFGALT FPSNSLLLDR AARFSVIATE QNGNFSGETA  120
NSLPSNPGAN LDRVKAEPAE TDSMVENQNQ SYSSGKRKER EKKVKSSTKK NKSSVESDKL  180
PYVHVRARRG QATDNHSLAE RARREKINAR MKLLQELVPG CDKIQGTALV LDEIINHVQT  240
LQRQVEMLSM RLAAVNPRID FNLDSILASE NGSLMDGSFN AESYHQLQQW PFDGYHQPEW  300
GREEDHHQAN FSMGSATLHP NQVKMEL
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.284950.0flower| inflorescence| leaf
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible265880_at1e-151
Expression AtlasAT2G42300-
AtGenExpressAT2G42300-
ATTED-IIAT2G42300-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in leaves, stems, and flowers. {ECO:0000269|PubMed:12679534}.
Function -- GeneRIF ? help Back to Top
  1. bHLH48 and bHLH60 positively regulate gibberellin-mediated flowering
    [PMID: 28591805]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G42300.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G63090
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G42300
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK1766340.0AK176634.1 Arabidopsis thaliana mRNA for putative bHLH transcription factor (bHLH048), complete cds, clone: RAFL25-17-F11.
GenBankAY0654110.0AY065411.1 Arabidopsis thaliana unknown protein (At2g42300) mRNA, complete cds.
GenBankAY0965210.0AY096521.1 Arabidopsis thaliana unknown protein (At2g42300) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_850368.10.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
SwissprotQ8VZ020.0BH048_ARATH; Transcription factor bHLH48
TrEMBLD7LI390.0D7LI39_ARALL; Uncharacterized protein
STRINGAT2G42300.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM25762771
Representative plantOGRP5816313
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
    [PMID:14576160]
  5. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  6. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  7. Mandaokar A, et al.
    Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling.
    Plant J., 2006. 46(6): p. 984-1008
    [PMID:16805732]
  8. Husbands A,Bell EM,Shuai B,Smith HM,Springer PS
    LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins.
    Nucleic Acids Res., 2007. 35(19): p. 6663-71
    [PMID:17913740]
  9. Borges F, et al.
    Comparative transcriptomics of Arabidopsis sperm cells.
    Plant Physiol., 2008. 148(2): p. 1168-81
    [PMID:18667720]
  10. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  11. Li Y,Wang H,Li X,Liang G,Yu D
    Two DELLA-interacting proteins bHLH48 and bHLH60 regulate flowering under long-day conditions in Arabidopsis thaliana.
    J. Exp. Bot., 2017. 68(11): p. 2757-2767
    [PMID:28591805]