PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT2G41940.1

Common Name

T6D20.16, ZFP8

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

C2H2

Protein Properties

Length: 257aa MW: 29571.2 Da PI: 8.3017

Description

zinc finger protein 8

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT2G41940.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.4	5.3e-05	95	117	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C + F+++ L H++ H AT2G41940.1 95 FECHYCFRNFPTSQALGGHQNAH 117 89******************988 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	1.6E-5	91	123	No hit	No description
Pfam	PF13912	2.0E-5	94	119	IPR007087	Zinc finger, C2H2
PROSITE profile	PS50157	10.99	95	122	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	97	117	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007275	Biological Process	multicellular organism development
GO:0010026	Biological Process	trichome differentiation
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0008270	Molecular Function	zinc ion binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 257 aa Download sequence Send to blast
MDETNGRRET HDFMNVNVES FSQLPFIRRT PPKEKAAIIR LFGQELVGDN SDNLSAEPSD 60 HQTTTKNDES SENIKDKDKE KDKDKDKDNN NNRRFECHYC FRNFPTSQAL GGHQNAHKRE 120 RQHAKRGSMT SYLHHHQPHD PHHIYGFLNN HHHRHYPSWT TEARSYYGGG GHQTPSYYSR 180 NTLAPPSSNP PTINGSPLGL WRVPPSTSTN TIQGVYSSSP ASAFRSHEQE TNKEPNNWPY 240 RLMKPNVQDH VSLDLHL

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.20402	0.0	flower

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	42569852	0.0
Genevisible	267535_at	0.0
Expression Atlas	AT2G41940	-
AtGenExpress	AT2G41940	-
ATTED-II	AT2G41940	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in developing cauline leaves. {ECO:0000269\|PubMed:17507408}.

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes a zinc finger protein containing only a single zinc finger.
UniProt	Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Is not involved in the regulation of trichome branching. Is functionally equivalent to GIS2 (PubMed:17507408). Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development (PubMed:24808098). {ECO:0000269\|PubMed:17507408, ECO:0000269\|PubMed:24808098}.

Function -- GeneRIF ? help Back to Top
ZFP8 is the direct target of ZFP5 in controlling epidermal cell differentiation. [PMID: 21803862]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT2G41940.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By gibberellin. {ECO:0000269\|PubMed:17507408}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G66350 (R), AT2G01570 (A), AT2G36270 (R), AT3G03450 (R)

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G14920

Phenotype -- Disruption Phenotype ? help Back to Top
Source	Description
UniProt	DISRUPTION PHENOTYPE: Reduced trichome production on cauline leaves, stem branches and sepals. {ECO:0000269\|PubMed:17507408}.

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT2G41940

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY039597	0.0	AY039597.1 Arabidopsis thaliana At2g41940/T6D20.16 mRNA, complete cds.
GenBank	AY056093	0.0	AY056093.1 Arabidopsis thaliana At2g41940/T6D20.16 mRNA, complete cds.
GenBank	CP002685	0.0	CP002685.1 Arabidopsis thaliana chromosome 2, complete sequence.
GenBank	U90439	0.0	U90439.3 Arabidopsis thaliana chromosome 2 BAC T6D20 genomic sequence, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_181725.1	0.0	zinc finger protein 8
Swissprot	P93751	0.0	ZFP8_ARATH; Zinc finger protein 8
TrEMBL	A0A178W167	0.0	A0A178W167_ARATH; ZFP8
STRING	AT2G41940.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2495	19	49
Representative plant	OGRP2859	5	8

Link Out ? help Back to Top
Phytozome	AT2G41940.1
Entrez Gene	818794
iHOP	AT2G41940
wikigenes	AT2G41940

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Czechowski T,Bari RP,Stitt M,Scheible WR,Udvardi MK Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: unprecedented sensitivity reveals novel root- and shoot-specific genes. Plant J., 2004. 38(2): p. 366-79 [PMID:15078338] Englbrecht CC,Schoof H,B Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome. BMC Genomics, 2004. 5(1): p. 39 [PMID:15236668] Ramonell K, et al. Loss-of-function mutations in chitin responsive genes show increased susceptibility to the powdery mildew pathogen Erysiphe cichoracearum. Plant Physiol., 2005. 138(2): p. 1027-36 [PMID:15923325] Thilmony R,Underwood W,He SY Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7. Plant J., 2006. 46(1): p. 34-53 [PMID:16553894] Gan Y,Liu C,Yu H,Broun P Integration of cytokinin and gibberellin signalling by Arabidopsis transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate. Development, 2007. 134(11): p. 2073-81 [PMID:17507408] Gan Y,Yu H,Peng J,Broun P Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis. Plant Physiol., 2007. 145(3): p. 1031-42 [PMID:17704233] Ciftci-Yilmaz S,Mittler R The zinc finger network of plants. Cell. Mol. Life Sci., 2008. 65(7-8): p. 1150-60 [PMID:18193167] Yu N, et al. Temporal control of trichome distribution by microRNA156-targeted SPL genes in Arabidopsis thaliana. Plant Cell, 2010. 22(7): p. 2322-35 [PMID:20622149] Zhou Z, et al. Zinc finger protein5 is required for the control of trichome initiation by acting upstream of zinc finger protein8 in Arabidopsis. Plant Physiol., 2011. 157(2): p. 673-82 [PMID:21803862] Gaudinier A, et al. Enhanced Y1H assays for Arabidopsis. Nat. Methods, 2011. 8(12): p. 1053-5 [PMID:22037706] Causier B,Ashworth M,Guo W,Davies B The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol., 2012. 158(1): p. 423-38 [PMID:22065421] Zhou Z,An L,Sun L,Gan Y ZFP5 encodes a functionally equivalent GIS protein to control trichome initiation. Plant Signal Behav, 2012. 7(1): p. 28-30 [PMID:22301962] Zhou Z, et al. Zinc Finger Protein 6 (ZFP6) regulates trichome initiation by integrating gibberellin and cytokinin signaling in Arabidopsis thaliana. New Phytol., 2013. 198(3): p. 699-708 [PMID:23506479] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Joseph MP, et al. The Arabidopsis ZINC FINGER PROTEIN3 Interferes with Abscisic Acid and Light Signaling in Seed Germination and Plant Development. Plant Physiol., 2014. 165(3): p. 1203-1220 [PMID:24808098] Mar Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners. Plant Physiol., 2014. 166(2): p. 1022-32 [PMID:25118255] Sun L, et al. GLABROUS INFLORESCENCE STEMS3 (GIS3) regulates trichome initiation and development in Arabidopsis. New Phytol., 2015. 206(1): p. 220-30 [PMID:25640859] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Kim SY,Hyoung S,So WM,Shin JS The novel transcription factor TRP interacts with ZFP5, a trichome initiation-related transcription factor, and negatively regulates trichome initiation through gibberellic acid signaling. Plant Mol. Biol., 2018. 96(3): p. 315-326 [PMID:29335898] Tague BW,Goodman HM Characterization of a family of Arabidopsis zinc finger protein cDNAs. Plant Mol. Biol., 1995. 28(2): p. 267-79 [PMID:7599312]