PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G38340.1
Common NameDREB19, DREB2E, ERF046, T19C21.17
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 244aa    MW: 27370.2 Da    PI: 8.5804
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G38340.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2   1 55 
                  ++++GVr++  +g+WvAeIr+p++ +g    ++kr +lg+f ta eAa a+++a+  ++g
                  689*****99.**********888777877555*********************988776 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008471.5E-1368126IPR001471AP2/ERF domain
CDDcd000184.58E-1968136No hitNo description
SMARTSM003803.8E-3069140IPR001471AP2/ERF domain
SuperFamilySSF541715.62E-1969135IPR016177DNA-binding domain
PROSITE profilePS5103221.4369134IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.102.6E-2769135IPR001471AP2/ERF domain
PRINTSPR003673.2E-97081IPR001471AP2/ERF domain
PRINTSPR003673.2E-9100116IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009414Biological Processresponse to water deprivation
GO:0009651Biological Processresponse to salt stress
GO:0009738Biological Processabscisic acid-activated signaling pathway
GO:0034605Biological Processcellular response to heat
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000293anatomyguard cell
PO:0025195anatomypollen tube cell
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 244 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT2G38340-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in xylem tissues, stigma, anthers and region where sepals and petals attach the peduncle. {ECO:0000269|PubMed:21069430}.
Functional Description ? help Back to Top
Source Description
TAIRencodes a member of the DREB subfamily A-2 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are eight members in this subfamily including DREB2A AND DREB2B that are involved in response to drought.
UniProtTranscriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates abscisic acid-inducible transcription. Involved in the regulation of plant development and tolerance to abiotic stresses (PubMed:21069430). {ECO:0000269|PubMed:11798174, ECO:0000269|PubMed:21069430}.
Function -- GeneRIF ? help Back to Top
  1. Data demonstrate that RAP2.6 (At1g43160), RAP2.6L (At5g13330), DREB 26 (At1g21910) and DREB19 (At2g38340) are transactivators, they exhibit tissue specific expression, and participate in developmental processes as well as biotic/abiotic stress signaling.
    [PMID: 21069430]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By abscisic acid (ABA) treatment (PubMed:11798174). Induced by salt, heat and drought stresses. {ECO:0000269|PubMed:11798174}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G38340
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0046830.0AC004683.3 Arabidopsis thaliana chromosome 2 clone T19C21 map ve018, complete sequence.
GenBankAY0724210.0AY072421.1 Arabidopsis thaliana DREB-like AP2 domain transcription factor (At2g38340) mRNA, complete cds.
GenBankBT0062760.0BT006276.1 Arabidopsis thaliana At2g38340 mRNA, complete cds.
GenBankCP0026850.0CP002685.1 Arabidopsis thaliana chromosome 2, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001318372.10.0Integrase-type DNA-binding superfamily protein
SwissprotO809170.0DRE2E_ARATH; Dehydration-responsive element-binding protein 2E
TrEMBLA0A178W1W21e-178A0A178W1W2_ARATH; DREB19
STRINGAT2G38340.11e-180(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. Sakuma Y, et al.
    DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expression.
    Biochem. Biophys. Res. Commun., 2002. 290(3): p. 998-1009
  3. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  5. Scheible WR, et al.
    Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen.
    Plant Physiol., 2004. 136(1): p. 2483-99
  6. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  7. Truman W,de Zabala MT,Grant M
    Type III effectors orchestrate a complex interplay between transcriptional networks to modify basal defence responses during pathogenesis and resistance.
    Plant J., 2006. 46(1): p. 14-33
  8. Che P,Lall S,Nettleton D,Howell SH
    Gene expression programs during shoot, root, and callus development in Arabidopsis tissue culture.
    Plant Physiol., 2006. 141(2): p. 620-37
  9. Mandaokar A, et al.
    Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling.
    Plant J., 2006. 46(6): p. 984-1008
  10. Michel K,Abderhalden O,Bruggmann R,Dudler R
    Transcriptional changes in powdery mildew infected wheat and Arabidopsis leaves undergoing syringolin-triggered hypersensitive cell death at infection sites.
    Plant Mol. Biol., 2006. 62(4-5): p. 561-78
  11. Sattler SE, et al.
    Nonenzymatic lipid peroxidation reprograms gene expression and activates defense markers in Arabidopsis tocopherol-deficient mutants.
    Plant Cell, 2006. 18(12): p. 3706-20
  12. Culligan KM,Robertson CE,Foreman J,Doerner P,Britt AB
    ATR and ATM play both distinct and additive roles in response to ionizing radiation.
    Plant J., 2006. 48(6): p. 947-61
  13. Veyres N, et al.
    The Arabidopsis sweetie mutant is affected in carbohydrate metabolism and defective in the control of growth, development and senescence.
    Plant J., 2008. 55(4): p. 665-86
  14. Welling A,Palva ET
    Involvement of CBF transcription factors in winter hardiness in birch.
    Plant Physiol., 2008. 147(3): p. 1199-211
  15. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
  16. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
  17. Krishnaswamy SS, et al.
    Transcriptional profiling of pea ABR17 mediated changes in gene expression in Arabidopsis thaliana.
    BMC Plant Biol., 2008. 8: p. 91
  18. Dubos C, et al.
    MYB transcription factors in Arabidopsis.
    Trends Plant Sci., 2010. 15(10): p. 573-81
  19. Krishnaswamy S,Verma S,Rahman MH,Kav NN
    Functional characterization of four APETALA2-family genes (RAP2.6, RAP2.6L, DREB19 and DREB26) in Arabidopsis.
    Plant Mol. Biol., 2011. 75(1-2): p. 107-27
  20. Gaudinier A, et al.
    Enhanced Y1H assays for Arabidopsis.
    Nat. Methods, 2011. 8(12): p. 1053-5
  21. Mehterov N, et al.
    Oxidative stress provokes distinct transcriptional responses in the stress-tolerant atr7 and stress-sensitive loh2 Arabidopsis thaliana mutants as revealed by multi-parallel quantitative real-time PCR analysis of ROS marker and antioxidant genes.
    Plant Physiol. Biochem., 2012. 59: p. 20-9
  22. Huang KC,Lin WC,Cheng WH
    Salt hypersensitive mutant 9, a nucleolar APUM23 protein, is essential for salt sensitivity in association with the ABA signaling pathway in Arabidopsis.
    BMC Plant Biol., 2018. 18(1): p. 40