PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G22750.1
Common NameBHLH18, EN28, T30L20.1
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 304aa    MW: 33733.6 Da    PI: 9.5557
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G22750.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.79e-13126172455
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                   h  +Er+RR+++ ++f  L  l+P +     kK++Ka++L  A+++Ik+Lq
  AT2G22750.1 126 DHILAERKRREKLTQRFVALSALIPGL-----KKMDKASVLGDAIKHIKYLQ 172
                  5899***********************.....9******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088815.44122171IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.1E-17126186IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.6E-10126172IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474596.15E-17127190IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000836.53E-12127175No hitNo description
SMARTSM003533.2E-15128177IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0009031anatomysepal
PO:0007611developmental stagepetal differentiation and expansion stage
Sequence ? help Back to Top
Protein Sequence    Length: 304 aa     Download sequence    Send to blast
MNSLVGDVPQ SLSSLDDTTT CYNLDASCNK SLVEERPSKI LKTTHISPNL HPFSSSNPPP  60
PKHQPSSRIL SFEKTGLHVM NHNSPNLIFS PKDEEIGLPE HKKAELIIRG TKRAQSLTRS  120
QSNAQDHILA ERKRREKLTQ RFVALSALIP GLKKMDKASV LGDAIKHIKY LQESVKEYEE  180
QKKEKTMESV VLVKKSSLVL DENHQPSSSS SSDGNRNSSS SNLPEIEVRV SGKDVLIKIL  240
CEKQKGNVIK IMGEIEKLGL SITNSNVLPF GPTFDISIIA QNNNFDMKIE DVVKNLSFGL  300
SKLT
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1130135ERKRRE
2131136RKRREK
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible266454_at0.0
Expression AtlasAT2G22750-
AtGenExpressAT2G22750-
ATTED-IIAT2G22750-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots. {ECO:0000269|PubMed:12679534}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00273DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G22750.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cold treatment. {ECO:0000269|PubMed:12679534}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT1G14920
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G22750
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4885620.0AF488562.1 Arabidopsis thaliana clone bHLH018 putative bHLH transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001324634.10.0basic helix-loop-helix (bHLH) DNA-binding superfamily protein
SwissprotQ1PF170.0BH018_ARATH; Transcription factor bHLH18
TrEMBLA0A1P8B0Q30.0A0A1P8B0Q3_ARATH; Basic helix-loop-helix (BHLH) DNA-binding superfamily protein
STRINGAT2G22750.20.0(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  5. Matsushima R,Fukao Y,Nishimura M,Hara-Nishimura I
    NAI1 gene encodes a basic-helix-loop-helix-type putative transcription factor that regulates the formation of an endoplasmic reticulum-derived structure, the ER body.
    Plant Cell, 2004. 16(6): p. 1536-49
    [PMID:15155889]
  6. Underwood BA,Vanderhaeghen R,Whitford R,Town CD,Hilson P
    Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.
    Plant Biotechnol. J., 2006. 4(3): p. 317-24
    [PMID:17147637]
  7. Kanaoka MM, et al.
    SCREAM/ICE1 and SCREAM2 specify three cell-state transitional steps leading to arabidopsis stomatal differentiation.
    Plant Cell, 2008. 20(7): p. 1775-85
    [PMID:18641265]
  8. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  9. Tominaga-Wada R,Iwata M,Nukumizu Y,Wada T
    Analysis of IIId, IIIe and IVa group basic-helix-loop-helix proteins expressed in Arabidopsis root epidermis.
    Plant Sci., 2011. 181(4): p. 471-8
    [PMID:21889054]
  10. Mar
    Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners.
    Plant Physiol., 2014. 166(2): p. 1022-32
    [PMID:25118255]