PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G77850.1

Common Name

ARF17, F28K19.6, T32E8.16

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

ARF

Protein Properties

Length: 585aa MW: 63742 Da PI: 5.6001

Description

auxin response factor 17

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G77850.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	B3	76.2	3.7e-24	119	220	1	99
EEEE-..-HHHHTT-EE--HHH.HTT......---..--SEEEEEETTS-EEEEEE..EEETTEEEE-TTHHHHHHHHT--TT-EEEEEE-SSSEE.. CS B3 1 ffkvltpsdvlksgrlvlpkkfaeeh......ggkkeesktltledesgrsWevkliyrkksgryvltkGWkeFvkangLkegDfvvFkldgrsefel 92 f k+ltpsd+++ g +++p+ +a++ +++++ ++l ++d +g +W++++iyr++++r++lt+GW++Fv++++L +gD+vvF+ ++s e+ AT1G77850.1 119 FAKILTPSDANNGGGFSVPRFCADSVfpllnfQIDPPV-QKLYVTDIHGAVWDFRHIYRGTPRRHLLTTGWSKFVNSKKLIAGDSVVFM--RKSADEM 213 89***************9999999*9666655.49********************************************..4478889 PP EEEEE-S CS B3 93 vvkvfrk 99 +++v+r+ AT1G77850.1 214 FIGVRRT 220 9*997 PP
2	Auxin_resp	89.4	6.5e-30	274	356	1	83
Auxin_resp 1 aahaastksvFevvYnPrastseFvvkvekvekalkvkvsvGmRfkmafetedsserrl.sGtvvgvsdldpvrWpnSkWrsLk 83 a+++as++ +Fevv++P a++seFvv++e+ve+++++ +++G+R+kma+etedss++++ +G+v+++ + ++ W++S+W++L+ AT1G77850.1 274 AINRASQGLPFEVVFYPAAGWSEFVVRAEDVESSMSMYWTPGTRVKMAMETEDSSRITWfQGIVSSTYQ-ETGPWRGSPWKQLQ 356 67899****************************************************9999999999.888*******97 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:2.40.330.10	1.5E-32	112	223	IPR015300	DNA-binding pseudobarrel domain
SuperFamily	SSF101936	1.7E-27	113	225	IPR015300	DNA-binding pseudobarrel domain
PROSITE profile	PS50863	12.59	119	221	IPR003340	B3 DNA binding domain
SMART	SM01019	1.2E-20	119	221	IPR003340	B3 DNA binding domain
Pfam	PF02362	1.1E-21	119	220	IPR003340	B3 DNA binding domain
CDD	cd10017	4.70E-20	119	215	No hit	No description
Pfam	PF06507	2.7E-24	274	356	IPR010525	Auxin response factor

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009734	Biological Process	auxin-activated signaling pathway
GO:0010208	Biological Process	pollen wall assembly
GO:0048830	Biological Process	adventitious root development
GO:0052543	Biological Process	callose deposition in cell wall
GO:0005634	Cellular Component	nucleus
GO:0000987	Molecular Function	core promoter proximal region sequence-specific DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020094	anatomy	plant egg cell
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 585 aa Download sequence Send to blast
MSPPSATAGD INHREVDPTI WRACAGASVQ IPVLHSRVYY FPQGHVEHCC PLLSTLPSST 60 SPVPCIITSI QLLADPVTDE VFAHLILQPM TQQQFTPTNY SRFGRFDGDV DDNNKVTTFA 120 KILTPSDANN GGGFSVPRFC ADSVFPLLNF QIDPPVQKLY VTDIHGAVWD FRHIYRGTPR 180 RHLLTTGWSK FVNSKKLIAG DSVVFMRKSA DEMFIGVRRT PISSSDGGSS YYGGDEYNGY 240 YSQSSVAKED DGSPKKTFRR SGNGKLTAEA VTDAINRASQ GLPFEVVFYP AAGWSEFVVR 300 AEDVESSMSM YWTPGTRVKM AMETEDSSRI TWFQGIVSST YQETGPWRGS PWKQLQITWD 360 EPEILQNVKR VNPWQVEIAA HATQLHTPFP PAKRLKYPQP GGGFLSGDDG EILYPQSGLS 420 SAAAPDPSPS MFSYSTFPAG MQGARQYDFG SFNPTGFIGG NPPQLFTNNF LSPLPDLGKV 480 STEMMNFGSP PSDNLSPNSN TTNLSSGNDL VGNRGPLSKK VNSIQLFGKI ITVEEHSESG 540 PAESGLCEED GSKESSDNET QLSLSHAPPS VPKHSNSNAG SSSQG

Sequence ? help Back to Top

Protein Sequence Length: 585 aa Download sequence Send to blast

MSPPSATAGD INHREVDPTI WRACAGASVQ IPVLHSRVYY FPQGHVEHCC PLLSTLPSST  60
SPVPCIITSI QLLADPVTDE VFAHLILQPM TQQQFTPTNY SRFGRFDGDV DDNNKVTTFA  120
KILTPSDANN GGGFSVPRFC ADSVFPLLNF QIDPPVQKLY VTDIHGAVWD FRHIYRGTPR  180
RHLLTTGWSK FVNSKKLIAG DSVVFMRKSA DEMFIGVRRT PISSSDGGSS YYGGDEYNGY  240
YSQSSVAKED DGSPKKTFRR SGNGKLTAEA VTDAINRASQ GLPFEVVFYP AAGWSEFVVR  300
AEDVESSMSM YWTPGTRVKM AMETEDSSRI TWFQGIVSST YQETGPWRGS PWKQLQITWD  360
EPEILQNVKR VNPWQVEIAA HATQLHTPFP PAKRLKYPQP GGGFLSGDDG EILYPQSGLS  420
SAAAPDPSPS MFSYSTFPAG MQGARQYDFG SFNPTGFIGG NPPQLFTNNF LSPLPDLGKV  480
STEMMNFGSP PSDNLSPNSN TTNLSSGNDL VGNRGPLSKK VNSIQLFGKI ITVEEHSESG  540
PAESGLCEED GSKESSDNET QLSLSHAPPS VPKHSNSNAG SSSQG

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4ldu_A	1e-60	16	377	51	388	Auxin response factor 5
4ldv_A	4e-61	20	377	23	353	Auxin response factor 1
4ldw_A	4e-61	20	377	23	353	Auxin response factor 1
4ldw_B	4e-61	20	377	23	353	Auxin response factor 1
4ldx_A	5e-61	20	377	23	353	Auxin response factor 1
4ldx_B	5e-61	20	377	23	353	Auxin response factor 1
4ldy_A	5e-61	20	377	23	353	Auxin response factor 1
4ldy_B	5e-61	20	377	23	353	Auxin response factor 1
Search in ModeBase

Expression -- Microarray ? help Back to Top
Source	ID	E-value
Genevisible	262136_at	0.0
Expression Atlas	AT1G77850	-
AtGenExpress	AT1G77850	-
ATTED-II	AT1G77850	-

Functional Description ? help Back to Top
Source	Description
TAIR	Posttranscriptionally regulated by miR160 and is essential for proper development.Regulates early auxin response genes.
UniProt	Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. {ECO:0000269\|PubMed:12036261}.

Function -- GeneRIF ? help Back to Top
Phenotypic plasticity of adventitious rooting is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance. ARF17, a target of miR160, is a negative regulator. [PMID: 19820192] ARF17 is essential for pollen wall patterning in Arabidopsis by modulating primexine formation at least partially through direct regulation of CalS5 gene expression. [PMID: 23580594] This work shows that ARF17 plays an essential role in anther development and pollen formation, and ARF17 expression under miR160 regulation is critical for its function during anther development. [PMID: 29258431]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G77850.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT4G27260(R), AT5G54510(R)

Regulation -- MicroRNA ? help Back to Top
Source	Description
miRTarBase	Regulated by ath-miR160c, ath-miR160b, ath-miR160a

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	auxin

Interaction ? help Back to Top
Source	Intact With
IntAct	Search Q84WU6

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G77850

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	BT002749	0.0	BT002749.1 Arabidopsis thaliana clone C104833 auxin response factor ARF17 (At1g77850) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001322496.1	0.0	auxin response factor 17
Swissprot	Q84WU6	0.0	ARFQ_ARATH; Auxin response factor 17
TrEMBL	A0A1P8AU56	0.0	A0A1P8AU56_ARATH; Auxin response factor
STRING	AT1G77850.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM580	27	130
Representative plant	OGRP526	15	78

Link Out ? help Back to Top
Phytozome	AT1G77850.1
Entrez Gene	844120
iHOP	AT1G77850
wikigenes	AT1G77850

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Hagen G,Guilfoyle T Auxin-responsive gene expression: genes, promoters and regulatory factors. Plant Mol. Biol., 2002 Jun-Jul. 49(3-4): p. 373-85 [PMID:12036261] Kasschau KD, et al. P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction. Dev. Cell, 2003. 4(2): p. 205-17 [PMID:12586064] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Vazquez F,Gasciolli V,Cr The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing. Curr. Biol., 2004. 14(4): p. 346-51 [PMID:14972688] Vaucheret H,Vazquez F,Cr The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev., 2004. 18(10): p. 1187-97 [PMID:15131082] Remington DL,Vision TJ,Guilfoyle TJ,Reed JW Contrasting modes of diversification in the Aux/IAA and ARF gene families. Plant Physiol., 2004. 135(3): p. 1738-52 [PMID:15247399] Souret FF,Kastenmayer JP,Green PJ AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets. Mol. Cell, 2004. 15(2): p. 173-83 [PMID:15260969] Hass C, et al. The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis. EMBO J., 2004. 23(16): p. 3290-302 [PMID:15282545] Okushima Y, et al. Functional genomic analysis of the AUXIN RESPONSE FACTOR gene family members in Arabidopsis thaliana: unique and overlapping functions of ARF7 and ARF19. Plant Cell, 2005. 17(2): p. 444-63 [PMID:15659631] Mallory AC,Bartel DP,Bartel B MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes. Plant Cell, 2005. 17(5): p. 1360-75 [PMID:15829600] Sorin C, et al. Auxin and light control of adventitious rooting in Arabidopsis require ARGONAUTE1. Plant Cell, 2005. 17(5): p. 1343-59 [PMID:15829601] Axtell MJ,Bartel DP Antiquity of microRNAs and their targets in land plants. Plant Cell, 2005. 17(6): p. 1658-73 [PMID:15849273] Wang JW, et al. Control of root cap formation by MicroRNA-targeted auxin response factors in Arabidopsis. Plant Cell, 2005. 17(8): p. 2204-16 [PMID:16006581] Siemens J, et al. Transcriptome analysis of Arabidopsis clubroots indicate a key role for cytokinins in disease development. Mol. Plant Microbe Interact., 2006. 19(5): p. 480-94 [PMID:16673935] Wu F, et al. The N-terminal double-stranded RNA binding domains of Arabidopsis HYPONASTIC LEAVES1 are sufficient for pre-microRNA processing. Plant Cell, 2007. 19(3): p. 914-25 [PMID:17337628] Lewsey M,Robertson FC,Canto T,Palukaitis P,Carr JP Selective targeting of miRNA-regulated plant development by a viral counter-silencing protein. Plant J., 2007. 50(2): p. 240-52 [PMID:17444907] Goeres DC, et al. Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Plant Cell, 2007. 19(5): p. 1549-64 [PMID:17513503] Axtell MJ,Snyder JA,Bartel DP Common functions for diverse small RNAs of land plants. Plant Cell, 2007. 19(6): p. 1750-69 [PMID:17601824] Gifford ML,Dean A,Gutierrez RA,Coruzzi GM,Birnbaum KD Cell-specific nitrogen responses mediate developmental plasticity. Proc. Natl. Acad. Sci. U.S.A., 2008. 105(2): p. 803-8 [PMID:18180456] Ehrenreich IM,Purugganan MD Sequence variation of MicroRNAs and their binding sites in Arabidopsis. Plant Physiol., 2008. 146(4): p. 1974-82 [PMID:18305205] Ascencio-Ib Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. Plant Physiol., 2008. 148(1): p. 436-54 [PMID:18650403] Swaminathan K,Peterson K,Jack T The plant B3 superfamily. Trends Plant Sci., 2008. 13(12): p. 647-55 [PMID:18986826] Gutierrez L, et al. Phenotypic plasticity of adventitious rooting in Arabidopsis is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance. Plant Cell, 2009. 21(10): p. 3119-32 [PMID:19820192] Wuest SE, et al. Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes. Curr. Biol., 2010. 20(6): p. 506-12 [PMID:20226671] Varaud E, et al. AUXIN RESPONSE FACTOR8 regulates Arabidopsis petal growth by interacting with the bHLH transcription factor BIGPETALp. Plant Cell, 2011. 23(3): p. 973-83 [PMID:21421811] Vernoux T, et al. The auxin signalling network translates dynamic input into robust patterning at the shoot apex. Mol. Syst. Biol., 2011. 7: p. 508 [PMID:21734647] Causier B,Ashworth M,Guo W,Davies B The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol., 2012. 158(1): p. 423-38 [PMID:22065421] Reňák D,Dupl'áková N,Honys D Wide-scale screening of T-DNA lines for transcription factor genes affecting male gametophyte development in Arabidopsis. Sex. Plant Reprod., 2012. 25(1): p. 39-60 [PMID:22101548] Gutierrez L, et al. Auxin controls Arabidopsis adventitious root initiation by regulating jasmonic acid homeostasis. Plant Cell, 2012. 24(6): p. 2515-27 [PMID:22730403] Yang J, et al. AUXIN RESPONSE FACTOR17 is essential for pollen wall pattern formation in Arabidopsis. Plant Physiol., 2013. 162(2): p. 720-31 [PMID:23580594] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Shi ZH, et al. Overexpression of AtTTP affects ARF17 expression and leads to male sterility in Arabidopsis. PLoS ONE, 2015. 10(3): p. e0117317 [PMID:25822980] de Lucas M, et al. Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation. Plant Cell, 2016. 28(10): p. 2616-2631 [PMID:27650334] Wójcikowska B,Gaj MD Expression profiling of AUXIN RESPONSE FACTOR genes during somatic embryogenesis induction in Arabidopsis. Plant Cell Rep., 2017. 36(6): p. 843-858 [PMID:28255787] Wang B, et al. Fine regulation of ARF17 for anther development and pollen formation. BMC Plant Biol., 2017. 17(1): p. 243 [PMID:29258431] Wójcik AM,Nodine MD,Gaj MD miR160 and miR166/165 Contribute to the LEC2-Mediated Auxin Response Involved in the Somatic Embryogenesis Induction in Arabidopsis. Front Plant Sci, 2017. 8: p. 2024 [PMID:29321785] Lin JS, et al. MicroRNA160 Modulates Plant Development and Heat Shock Protein Gene Expression to Mediate Heat Tolerance in Arabidopsis. Front Plant Sci, 2018. 9: p. 68 [PMID:29449855]