PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G72360.1

Common Name

AtERF73, ERF073, ERF73, HRE1, T10D10.17

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

ERF

Protein Properties

Length: 211aa MW: 23661.2 Da PI: 4.5542

Description

ERF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G72360.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	63.5	4.6e-20	23	74	1	56
AP2 1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkklege 56 s+ykG+r+++ +grW+AeIrdp + r++lg+f taeeAa+a++ +k+++g+ AT1G72360.1 23 SRYKGIRRRP-WGRWAAEIRDPI----KgVRVWLGTFNTAEEAARAYDLEAKRIRGA 74 79******.******72....46***********************985 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54171	9.81E-23	23	82	IPR016177	DNA-binding domain
CDD	cd00018	3.55E-33	23	82	No hit	No description
Pfam	PF00847	1.5E-13	23	73	IPR001471	AP2/ERF domain
SMART	SM00380	6.6E-37	24	87	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	24.144	24	81	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	9.9E-31	24	82	IPR001471	AP2/ERF domain
PRINTS	PR00367	3.8E-11	25	36	IPR001471	AP2/ERF domain
PRINTS	PR00367	3.8E-11	47	63	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009873	Biological Process	ethylene-activated signaling pathway
GO:0034059	Biological Process	response to anoxia
GO:0071456	Biological Process	cellular response to hypoxia
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0009005	anatomy	root
PO:0009025	anatomy	vascular leaf
PO:0009030	anatomy	carpel
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0020030	anatomy	cotyledon
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 211 aa Download sequence Send to blast
MSQSFELYPW LGSASDGKKK QSSRYKGIRR RPWGRWAAEI RDPIKGVRVW LGTFNTAEEA 60 ARAYDLEAKR IRGAKAKLNF PNESSGKRKA KAKTVQQVEE NHEADLDVAV VSSAPSSSCL 120 DFLWEENNPD TLLIDTQWLE DIIMGDANKK HEPNDSEEAN NVDASLLSEE LLAFENQTEY 180 FSQMPFTEGN CDSSTSLSSL FDGGNDMGLW S

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5wx9_A	2e-21	21	83	11	74	Ethylene-responsive transcription factor ERF096
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	17	30	KKKQSSRYKGIRRR

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30698868	0.0
Genevisible	260451_at	0.0
Expression Atlas	AT1G72360	-
AtGenExpress	AT1G72360	-
ATTED-II	AT1G72360	-

Functional Description ? help Back to Top
Source	Description
TAIR	encodes a member of the ERF (ethylene response factor) subfamily B-2 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 5 members in this subfamily including RAP2.2 AND RAP2.12.
UniProt	Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250}.

Function -- GeneRIF ? help Back to Top
rotein localized in the nucleus and functioned as an in vivo transcription activator as confirmed in transient assays and experiments. [PMID: 15980186] HRE1 and HRE2 encode two nuclear-localized ethylene response factors specifically up-regulated under low oxygen conditions. [PMID: 20113439] AtERF73/HRE1 is involved in modulating ethylene responses under both normoxia and hypoxia. [PMID: 21398256] controlled by 3 pathways during hypoxia: an ethylene-dependent pathway, an ethylene-independent/H 2O 2-dependent pathway, and an ethylene and H 2O 2-independent pathway [PMID: 24698791] HRE1alpha functions as a transcription activator in the nucleus, and plays an important role in root development through regulation of root meristem cell division. [PMID: 24728113] AtERF73/HRE1 plays a role in H2O2 production by affecting the hypoxia-induced expression of Rboh genes in hypoxia signal transduction. [PMID: 27995331]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00230	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G72360.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	ethylene

Interaction ? help Back to Top
Source	Intact With
IntAct	Search Q8H0T5

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G72360

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC016529	0.0	AC016529.7 Arabidopsis thaliana chromosome 1 BAC T10D10 genomic sequence, complete sequence.
GenBank	BT002063	0.0	BT002063.1 Arabidopsis thaliana putative AP2 domain transcription factor (At1g72360) mRNA, complete cds.
GenBank	BT006259	0.0	BT006259.1 Arabidopsis thaliana At1g72360 mRNA, complete cds.
GenBank	CP002684	0.0	CP002684.1 Arabidopsis thaliana chromosome 1 sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_177380.2	1e-156	Integrase-type DNA-binding superfamily protein
Swissprot	Q8H0T5	1e-157	ERF73_ARATH; Ethylene-responsive transcription factor ERF073
TrEMBL	A0A178W8F1	1e-144	A0A178W8F1_ARATH; HRE1
TrEMBL	F4IDA7	1e-144	F4IDA7_ARATH; Integrase-type DNA-binding superfamily protein
STRING	AT1G72360.2	1e-145	(Arabidopsis thaliana)

Link Out ? help Back to Top
Phytozome	AT1G72360.1
Entrez Gene	843568
iHOP	AT1G72360
wikigenes	AT1G72360

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Shin R,Schachtman DP Hydrogen peroxide mediates plant root cell response to nutrient deprivation. Proc. Natl. Acad. Sci. U.S.A., 2004. 101(23): p. 8827-32 [PMID:15173595] Sahr T,Voigt G,Paretzke HG,Schramel P,Ernst D Caesium-affected gene expression in Arabidopsis thaliana. New Phytol., 2005. 165(3): p. 747-54 [PMID:15720685] Nawy T, et al. Transcriptional profile of the Arabidopsis root quiescent center. Plant Cell, 2005. 17(7): p. 1908-25 [PMID:15937229] Ogawa T, et al. Functional analysis of Arabidopsis ethylene-responsive element binding protein conferring resistance to Bax and abiotic stress-induced plant cell death. Plant Physiol., 2005. 138(3): p. 1436-45 [PMID:15980186] Nakayama N, et al. Gene trap lines define domains of gene regulation in Arabidopsis petals and stamens. Plant Cell, 2005. 17(9): p. 2486-506 [PMID:16055634] Nakano T,Suzuki K,Fujimura T,Shinshi H Genome-wide analysis of the ERF gene family in Arabidopsis and rice. Plant Physiol., 2006. 140(2): p. 411-32 [PMID:16407444] Licausi F, et al. HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect anaerobic responses in Arabidopsis thaliana. Plant J., 2010. 62(2): p. 302-15 [PMID:20113439] Licausi F, et al. Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability. New Phytol., 2011. 190(2): p. 442-56 [PMID:20840511] Yang CY,Hsu FC,Li JP,Wang NN,Shih MC The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis. Plant Physiol., 2011. 156(1): p. 202-12 [PMID:21398256] Hess N,Klode M,Anders M,Sauter M The hypoxia responsive transcription factor genes ERF71/HRE2 and ERF73/HRE1 of Arabidopsis are differentially regulated by ethylene. Physiol Plant, 2011. 143(1): p. 41-9 [PMID:21615413] Arabidopsis Interactome Mapping Consortium Evidence for network evolution in an Arabidopsis interactome map. Science, 2011. 333(6042): p. 601-7 [PMID:21798944] Gibbs DJ, et al. Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants. Nature, 2011. 479(7373): p. 415-8 [PMID:22020279] Yang CY Ethylene and hydrogen peroxide are involved in hypoxia signaling that modulates AtERF73/HRE1 expression. Plant Signal Behav, 2014. 9(3): p. e28583 [PMID:24698791] Seok HY,Tarte VN,Lee SY,Park HY,Moon YH Arabidopsis HRE1α, a splicing variant of AtERF73/HRE1, functions as a nuclear transcription activator in hypoxia response and root development. Plant Cell Rep., 2014. 33(8): p. 1255-62 [PMID:24728113] Yang CY,Huang YC,Ou SL ERF73/HRE1 is involved in H2O2 production via hypoxia-inducible Rboh gene expression in hypoxia signaling. Protoplasma, 2017. 254(4): p. 1705-1714 [PMID:27995331] Riechmann JL,Meyerowitz EM The AP2/EREBP family of plant transcription factors. Biol. Chem., 1998. 379(6): p. 633-46 [PMID:9687012]