PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G68640.1

Common Name

F24J5.12, PAN, TGA8

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

bZIP

Protein Properties

Length: 452aa MW: 50457.5 Da PI: 6.2365

Description

bZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G68640.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	bZIP_1	32	2.6e-10	166	206	5	42
CHHHCHHHHHHHHHHHHHHHHHHHHHHHH...HHHHHHHHH CS bZIP_1 5 krerrkqkNReAArrsRqRKkaeieeLee...kvkeLeaeN 42 + rr+++NReAAr+sR+RKka++++Le+ + ++Le+e AT1G68640.1 166 RTLRRLAQNREAARKSRLRKKAYVQQLENsriRLAQLEEEL 206 456999*********************98333455555554 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.20.5.170	8.5E-8	158	211	No hit	No description
SMART	SM00338	7.1E-7	162	233	IPR004827	Basic-leucine zipper domain
PROSITE profile	PS50217	9.404	164	208	IPR004827	Basic-leucine zipper domain
Pfam	PF00170	5.2E-7	166	206	IPR004827	Basic-leucine zipper domain
CDD	cd14708	9.23E-21	166	214	No hit	No description
SuperFamily	SSF57959	2.17E-6	166	209	No hit	No description
PROSITE pattern	PS00036	0	169	184	IPR004827	Basic-leucine zipper domain
Pfam	PF14144	1.3E-27	251	324	IPR025422	Transcription factor TGA like domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009909	Biological Process	regulation of flower development
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0005515	Molecular Function	protein binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000037	anatomy	shoot apex
PO:0006081	anatomy	primary root apical meristem
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009031	anatomy	sepal
PO:0009046	anatomy	flower
PO:0009049	anatomy	inflorescence
PO:0020003	anatomy	plant ovule
PO:0020130	anatomy	central root cap
PO:0020149	anatomy	quiescent center
PO:0025022	anatomy	collective leaf structure
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007611	developmental stage	petal differentiation and expansion stage

Sequence ? help Back to Top
Protein Sequence Length: 452 aa Download sequence Send to blast
MQSSFKTVPF TPDFYSQSSY FFRGDSCLEE FHQPVNGFHH EEAIDLSPNV TIASANLHYT 60 TFDTVMDCGG GGGGGLRERL EGGEEECLDT GQLVYQKGTR LVGGGVGEVN SSWCDSVSAM 120 ADNSQHTDTS TDIDTDDKTQ LNGGHQGMLL ATNCSDQSNV KSSDQRTLRR LAQNREAARK 180 SRLRKKAYVQ QLENSRIRLA QLEEELKRAR QQGSLVERGV SADHTHLAAG NGVFSFELEY 240 TRWKEEHQRM INDLRSGVNS QLGDNDLRVL VDAVMSHYDE IFRLKGIGTK VDVFHMLSGM 300 WKTPAERFFM WLGGFRSSEL LKILGNHVDP LTDQQLIGIC NLQQSSQQAE DALSQGMEAL 360 QQSLLETLSS ASMGPNSSAN VADYMGHMAM AMGKLGTLEN FLRQADLLRQ QTLQQLHRIL 420 TTRQAARAFL VIHDYISRLR ALSSLWLARP RD

Sequence ? help Back to Top

Protein Sequence Length: 452 aa Download sequence Send to blast

MQSSFKTVPF TPDFYSQSSY FFRGDSCLEE FHQPVNGFHH EEAIDLSPNV TIASANLHYT  60
TFDTVMDCGG GGGGGLRERL EGGEEECLDT GQLVYQKGTR LVGGGVGEVN SSWCDSVSAM  120
ADNSQHTDTS TDIDTDDKTQ LNGGHQGMLL ATNCSDQSNV KSSDQRTLRR LAQNREAARK  180
SRLRKKAYVQ QLENSRIRLA QLEEELKRAR QQGSLVERGV SADHTHLAAG NGVFSFELEY  240
TRWKEEHQRM INDLRSGVNS QLGDNDLRVL VDAVMSHYDE IFRLKGIGTK VDVFHMLSGM  300
WKTPAERFFM WLGGFRSSEL LKILGNHVDP LTDQQLIGIC NLQQSSQQAE DALSQGMEAL  360
QQSLLETLSS ASMGPNSSAN VADYMGHMAM AMGKLGTLEN FLRQADLLRQ QTLQQLHRIL  420
TTRQAARAFL VIHDYISRLR ALSSLWLARP RD

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	42563054	0.0
Genevisible	262278_at	0.0
Expression Atlas	AT1G68640	-
AtGenExpress	AT1G68640	-
ATTED-II	AT1G68640	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in the apical meristem, the floral meristem, each whorl of organ primordia, and in ovule primordia during wild-type flower development. {ECO:0000269\|PubMed:9990857}.

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes bZIP-transcription factor. Mutant plants have extra floral organs. PAN is essential for AG activation in early flowers of short-day-grown plants.
UniProt	Transcriptional activator involved in the determination of floral organ number. Acts to determine floral organ patterning by establishing floral organ primordia in specific numbers and positions. Plays a role in regulating stem cell fate by directly controlling AG expression. Binds to the 5'-AAGAAT-3' cis-acting element found in AG promoter. Might represent a target for a post-translational modification by GRXC7/ROXY1. {ECO:0000269\|PubMed:19395638, ECO:0000269\|PubMed:19395639, ECO:0000269\|PubMed:9990857}.

Function -- GeneRIF ? help Back to Top
PERIANTHIA (PAN) plays a role in regulating stem cell fate by directly controlling AG expression and suggest that this activity is spatially restricted to the centermost region of the AG expression domain. [PMID: 19395638] PAN and AG are engaged in a negative-feedback loop, which might be mediated by the stem-cell-inducing transcription factor WUSCHEL (WUS). [PMID: 19395639] The N-terminal PAN cysteines participate in a redox-dependent control of the PAN interaction with a highly conserved regulatory AG cis-element, emphasizing the importance of redox-modifications in the regulation of flower developmental processes. [PMID: 27128442]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G68640.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT4G18960 (R)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT2G17950(R), AT4G18960(A)

Interaction ? help Back to Top
Source	Intact With
IntAct	Search Q9SX27

Phenotype -- Disruption Phenotype ? help Back to Top
Source	Description
UniProt	DISRUPTION PHENOTYPE: Mutant plants have extra floral organs. The modal numbers of organs in mutant flowers are 5 sepals, 5 petals, 5 stamens, and 2 carpels in contrast with the tetramerous pattern of the wild type. {ECO:0000269\|PubMed:8620853, ECO:0000269\|PubMed:9990857}.

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G68640

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK118286	0.0	AK118286.1 Arabidopsis thaliana At1g68640 mRNA for putative bZip transcription factor PERIANTHIA (PAN) / AtbZip46, complete cds, clone: RAFL19-57-M21.
GenBank	BT008586	0.0	BT008586.1 Arabidopsis thaliana clone U50929 putative bZIP transcription factor, PERIANTHIA (At1g68640) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_177031.1	0.0	bZIP transcription factor family protein
Swissprot	Q9SX27	0.0	PAN_ARATH; Transcription factor PERIANTHIA
TrEMBL	A0A178W5Z4	0.0	A0A178W5Z4_ARATH; TGA8
STRING	AT1G68640.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM667	28	133
Representative plant	OGRP722	16	67

Link Out ? help Back to Top
Phytozome	AT1G68640.1
Entrez Gene	843194
iHOP	AT1G68640
wikigenes	AT1G68640

Publications ? help Back to Top
Meyerowitz EM,Running MP,Sakai H,Williams RW Multiple modes of cell division control in Arabidopsis flower development. Symp. Soc. Exp. Biol., 1998. 51: p. 19-26 [PMID:10645419] Chuang CF,Meyerowitz EM Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A., 2000. 97(9): p. 4985-90 [PMID:10781109] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Fletcher JC The ULTRAPETALA gene controls shoot and floral meristem size in Arabidopsis. Development, 2001. 128(8): p. 1323-33 [PMID:11262233] Jakoby M, et al. bZIP transcription factors in Arabidopsis. Trends Plant Sci., 2002. 7(3): p. 106-11 [PMID:11906833] Seki M, et al. Functional annotation of a full-length Arabidopsis cDNA collection. Science, 2002. 296(5565): p. 141-5 [PMID:11910074] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Hepworth SR,Zhang Y,McKim S,Li X,Haughn GW BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis. Plant Cell, 2005. 17(5): p. 1434-48 [PMID:15805484] Nawy T, et al. Transcriptional profile of the Arabidopsis root quiescent center. Plant Cell, 2005. 17(7): p. 1908-25 [PMID:15937229] Li S, et al. Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana. Plant Cell, 2009. 21(2): p. 429-41 [PMID:19218396] Skinner DJ,Gasser CS Expression-based discovery of candidate ovule development regulators through transcriptional profiling of ovule mutants. BMC Plant Biol., 2009. 9: p. 29 [PMID:19291320] Das P, et al. Floral stem cell termination involves the direct regulation of AGAMOUS by PERIANTHIA. Development, 2009. 136(10): p. 1605-11 [PMID:19395638] Maier AT, et al. Dual roles of the bZIP transcription factor PERIANTHIA in the control of floral architecture and homeotic gene expression. Development, 2009. 136(10): p. 1613-20 [PMID:19395639] Krizek B AINTEGUMENTA and AINTEGUMENTA-LIKE6 act redundantly to regulate Arabidopsis floral growth and patterning. Plant Physiol., 2009. 150(4): p. 1916-29 [PMID:19542297] Irish VF The flowering of Arabidopsis flower development. Plant J., 2010. 61(6): p. 1014-28 [PMID:20409275] Xu M, et al. Arabidopsis BLADE-ON-PETIOLE1 and 2 promote floral meristem fate and determinacy in a previously undefined pathway targeting APETALA1 and AGAMOUS-LIKE24. Plant J., 2010. 63(6): p. 974-89 [PMID:20626659] Li S,Gutsche N,Zachgo S The ROXY1 C-terminal L**LL motif is essential for the interaction with TGA transcription factors. Plant Physiol., 2011. 157(4): p. 2056-68 [PMID:21960138] Zander M,Chen S,Imkampe J,Thurow C,Gatz C Repression of the Arabidopsis thaliana jasmonic acid/ethylene-induced defense pathway by TGA-interacting glutaredoxins depends on their C-terminal ALWL motif. Mol Plant, 2012. 5(4): p. 831-40 [PMID:22207719] Z JAIBA, a class-II HD-ZIP transcription factor involved in the regulation of meristematic activity, and important for correct gynoecium and fruit development in Arabidopsis. Plant J., 2012. 71(2): p. 314-26 [PMID:22409594] Maier AT,Stehling-Sun S,Offenburger SL,Lohmann JU The bZIP Transcription Factor PERIANTHIA: A Multifunctional Hub for Meristem Control. Front Plant Sci, 2011. 2: p. 79 [PMID:22645551] Canet JV,Dob The BLADE-ON-PETIOLE genes of Arabidopsis are essential for resistance induced by methyl jasmonate. BMC Plant Biol., 2012. 12: p. 199 [PMID:23116333] Chandler JW,Werr W Arabidopsis floral phytomer development: auxin response relative to biphasic modes of organ initiation. J. Exp. Bot., 2014. 65(12): p. 3097-110 [PMID:24744428] Wynn AN,Seaman AA,Jones AL,Franks RG Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development. Front Plant Sci, 2014. 5: p. 130 [PMID:24778638] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Gutsche N,Zachgo S The N-Terminus of the Floral Arabidopsis TGA Transcription Factor PERIANTHIA Mediates Redox-Sensitive DNA-Binding. PLoS ONE, 2016. 11(4): p. e0153810 [PMID:27128442] de Luis Balaguer MA, et al. Predicting gene regulatory networks by combining spatial and temporal gene expression data in Arabidopsis root stem cells. Proc. Natl. Acad. Sci. U.S.A., 2017. 114(36): p. E7632-E7640 [PMID:28827319] Running MP,Meyerowitz EM Mutations in the PERIANTHIA gene of Arabidopsis specifically alter floral organ number and initiation pattern. Development, 1996. 122(4): p. 1261-9 [PMID:8620853] Roe JL,Nemhauser JL,Zambryski PC TOUSLED participates in apical tissue formation during gynoecium development in Arabidopsis. Plant Cell, 1997. 9(3): p. 335-53 [PMID:9090879] Sessions A, et al. ETTIN patterns the Arabidopsis floral meristem and reproductive organs. Development, 1997. 124(22): p. 4481-91 [PMID:9409666] Chuang CF,Running MP,Williams RW,Meyerowitz EM The PERIANTHIA gene encodes a bZIP protein involved in the determination of floral organ number in Arabidopsis thaliana. Genes Dev., 1999. 13(3): p. 334-44 [PMID:9990857]