PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G63650.2

Common Name

AtEGL3, ATMYC-2, BHLH2, EGL1, EGL3, EN30, F24D7.16, MYC146

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

bHLH

Protein Properties

Length: 596aa MW: 66620 Da PI: 4.8068

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G63650.2	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	45	2e-14	405	451	4	55
HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 +h E++RR+++N++f +Lr+++P+ + K +K++iL ++eY+++Lq AT1G63650.2 405 NHALSEKKRREKLNERFMTLRSIIPSiS------KIDKVSILDDTIEYLQDLQ 451 79999*******************66......****************9 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF14215	2.5E-54	13	202	IPR025610	Transcription factor MYC/MYB N-terminal
PROSITE profile	PS50888	16.869	401	450	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	2.52E-15	405	455	No hit	No description
Pfam	PF00010	6.5E-12	405	451	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	3.4E-18	405	468	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	1.1E-17	405	468	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	7.7E-17	407	456	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007275	Biological Process	multicellular organism development
GO:0009957	Biological Process	epidermal cell fate specification
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0005515	Molecular Function	protein binding
GO:0046983	Molecular Function	protein dimerization activity

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000037	anatomy	shoot apex
PO:0006036	anatomy	root epidermis
PO:0006504	anatomy	leaf trichome
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009052	anatomy	flower pedicel
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007039	developmental stage	leaf trichome development stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 596 aa Download sequence Send to blast
MATGENRTVP DNLKKQLAVS VRNIQWSYGI FWSVSASQPG VLEWGDGYYN GDIKTRKTIQ 60 AAEVKIDQLG LERSEQLREL YESLSLAESS ASGSSQVTRR ASAAALSPED LTDTEWYYLV 120 CMSFVFNIGE GIPGGALSNG EPIWLCNAET ADSKVFTRSL LAKSASLQTV VCFPFLGGVL 180 EIGTTEHIKE DMNVIQSVKT LFLEAPPYTT ISTRSDYQEI FDPLSDDKYT PVFITEAFPT 240 TSTSGFEQEP EDHDSFINDG GASQVQSWQF VGEEISNCIH QSLNSSDCVS QTFVGTTGRL 300 ACDPRKSRIQ RLGQIQEQSN HVNMDDDVHY QGVISTIFKT THQLILGPQF QNFDKRSSFT 360 RWKRSSSVKT LGEKSQKMIK KILFEVPLMN KKEELLPDTP EETGNHALSE KKRREKLNER 420 FMTLRSIIPS ISKIDKVSIL DDTIEYLQDL QKRVQELESC RESADTETRI TMMKRKKPDD 480 EEERASANCM NSKRKGSDVN VGEDEPADIG YAGLTDNLRI SSLGNEVVIE LRCAWREGIL 540 LEIMDVISDL NLDSHSVQSS TGDGLLCLTV NCKHKGTKIA TTGMIQEALQ RVAWIC

Sequence ? help Back to Top

Protein Sequence Length: 596 aa Download sequence Send to blast

MATGENRTVP DNLKKQLAVS VRNIQWSYGI FWSVSASQPG VLEWGDGYYN GDIKTRKTIQ  60
AAEVKIDQLG LERSEQLREL YESLSLAESS ASGSSQVTRR ASAAALSPED LTDTEWYYLV  120
CMSFVFNIGE GIPGGALSNG EPIWLCNAET ADSKVFTRSL LAKSASLQTV VCFPFLGGVL  180
EIGTTEHIKE DMNVIQSVKT LFLEAPPYTT ISTRSDYQEI FDPLSDDKYT PVFITEAFPT  240
TSTSGFEQEP EDHDSFINDG GASQVQSWQF VGEEISNCIH QSLNSSDCVS QTFVGTTGRL  300
ACDPRKSRIQ RLGQIQEQSN HVNMDDDVHY QGVISTIFKT THQLILGPQF QNFDKRSSFT  360
RWKRSSSVKT LGEKSQKMIK KILFEVPLMN KKEELLPDTP EETGNHALSE KKRREKLNER  420
FMTLRSIIPS ISKIDKVSIL DDTIEYLQDL QKRVQELESC RESADTETRI TMMKRKKPDD  480
EEERASANCM NSKRKGSDVN VGEDEPADIG YAGLTDNLRI SSLGNEVVIE LRCAWREGIL  540
LEIMDVISDL NLDSHSVQSS TGDGLLCLTV NCKHKGTKIA TTGMIQEALQ RVAWIC

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4rqw_A	9e-16	11	202	7	192	Transcription factor MYC3
4rqw_B	9e-16	11	202	7	192	Transcription factor MYC3
4rs9_A	9e-16	11	202	7	192	Transcription factor MYC3
4yz6_A	9e-16	11	202	7	192	Transcription factor MYC3
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	410	415	KKRREK

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.25024	0.0	flower\| seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
Genevisible	260242_at	0.0
Expression Atlas	AT1G63650	-
AtGenExpress	AT1G63650	-
ATTED-II	AT1G63650	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Localized in trichome developing region of leaves, prior to trichome initiation. Levels increase in initiating and young trichome cells, but dropped in the pavement cells between trichomes. Disappears in mature trichomes. {ECO:0000269\|PubMed:12917293}.
Uniprot	TISSUE SPECIFICITY: Ubiquitous with higher levels in buds and flowers. Specifically localized in developing root hair cells. Expressed in epidermal root hair cells (trichoblasts) and moves to root hairless cells (atrichoblasts) by a cell-to-cell movement through plasmodesmata (at protein level). {ECO:0000269\|PubMed:12956536, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:15590742}.

Functional Description ? help Back to Top
Source	Description
TAIR	Mutant has reduced trichomes, anthocyanin, and seed coat mucilage and abnormally patterned stomates. Encodes a bHLH Transcription Factor 1. The protein is functionally redundant with GL3 and TT8 and interacts with TTG1, the myb proteins GL1, PAP1 and 2, CPC and TRY, and it will form heterodimers with GL3. Expression in N (non-hair cell forming) cell layers is negatively regulated by WER. Expression in H cells (hair cell forming) is promoted by CPC/TRY.
UniProt	Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involved in seed mucilage production. Activates the transcription of GL2. {ECO:0000269\|PubMed:12917293, ECO:0000269\|PubMed:12956536, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:15361138, ECO:0000269\|PubMed:15590742}.

Function -- GeneRIF ? help Back to Top
GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis [EGL3] [PMID: 15590742] Anthocyanins accumulate in both wild type and egl3, but not in gl3 loss-of-function mutants when depleted of nitrogen. [PMID: 19621239] EGL3 activity is under proteasome-dependent proteolysis control. [PMID: 23373825] Localization of CPC in the nucleus requires the H-cell-expressed ENHANCER OF GLABRA3 (EGL3). [PMID: 23832626] WER expressed ubiquitously in the root induced GL2 expression only in the root epidermis, whereas co-expression of WER and EGL3 induced GL2 expression in the corresponding tissues. [PMID: 26408906] the C-terminal domain of the bHLH members (GLABRA3 [GL3], ENHANCER OF GLABRA3 [EGL3] and TRANSPARENT TESTA8 [TT8]) interacted with JAZs. [PMID: 29293407]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G63650.2

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By UV treatment. Negatively regulated by MYB66/WER, GL3 and BHLH2 in the developing non-hair cells, and positively regulated by CPC and TRY in the developing hair cells. {ECO:0000269\|PubMed:12679534, ECO:0000269\|PubMed:15590742}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G71030 (R), AT2G46410 (A), AT5G07100 (R)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT1G01380(A), AT1G71030(A), AT1G79840(A), AT2G23550(A), AT2G23580(A), AT2G37260(A), AT2G46410(A), AT4G01060(A), AT4G09820(A), AT4G22880(R), AT5G08640(R), AT5G13930(R), AT5G53200(A)

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	Jasmonic acid

Interaction -- BIND ? help Back to Top
Source	Intact With	Description
BIND	AT1G63650	EGL3 interacts with another molecule of EGL3 to form a dimer.
BIND	AT1G66370	EGL3 interacts with MYB113.
BIND	AT1G66380	EGL3 interacts with MYB114.
BIND	AT1G66390	EGL3 interacts with PAP2.

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G63650, AT1G66370, AT1G66380, AT1G66390
IntAct	Search Q9CAD0

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G63650

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF251687	0.0	AF251687.1 Arabidopsis thaliana putative transcription factor BHLH2 (BHLH2) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001185302.1	0.0	basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Refseq	NP_176552.1	0.0	basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Refseq	NP_974080.1	0.0	basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Swissprot	Q9CAD0	0.0	EGL1_ARATH; Transcription factor EGL1
TrEMBL	A0A384LNI2	0.0	A0A384LNI2_ARATH; EGL3
TrEMBL	C0SV14	0.0	C0SV14_ARATH; Uncharacterized protein At1g63650 (Fragment)
STRING	AT1G63650.3	0.0	(Arabidopsis thaliana)

Link Out ? help Back to Top
Phytozome	AT1G63650.2
Entrez Gene	842669
iHOP	AT1G63650
wikigenes	AT1G63650

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Sawa S Overexpression of the AtmybL2 gene represses trichome development in Arabidopsis. DNA Res., 2002. 9(2): p. 31-4 [PMID:12056412] Heim MA, et al. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol. Biol. Evol., 2003. 20(5): p. 735-47 [PMID:12679534] Toledo-Ortiz G,Huq E,Quail PH The Arabidopsis basic/helix-loop-helix transcription factor family. Plant Cell, 2003. 15(8): p. 1749-70 [PMID:12897250] Zhang F,Gonzalez A,Zhao M,Payne CT,Lloyd A A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis. Development, 2003. 130(20): p. 4859-69 [PMID:12917293] Ramsay NA,Walker AR,Mooney M,Gray JC Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant. Plant Mol. Biol., 2003. 52(3): p. 679-88 [PMID:12956536] Bernhardt C, et al. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Development, 2003. 130(26): p. 6431-9 [PMID:14627722] Zimmermann IM,Heim MA,Weisshaar B,Uhrig JF Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J., 2004. 40(1): p. 22-34 [PMID:15361138] Montiel G,Gantet P,Jay-Allemand C,Breton C Transcription factor networks. Pathways to the knowledge of root development. Plant Physiol., 2004. 136(3): p. 3478-85 [PMID:15542499] Bernhardt C,Zhao M,Gonzalez A,Lloyd A,Schiefelbein J The bHLH genes GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis. Development, 2005. 132(2): p. 291-8 [PMID:15590742] Broun P Transcriptional control of flavonoid biosynthesis: a complex network of conserved regulators involved in multiple aspects of differentiation in Arabidopsis. Curr. Opin. Plant Biol., 2005. 8(3): p. 272-9 [PMID:15860424] Serna L Epidermal cell patterning and differentiation throughout the apical-basal axis of the seedling. J. Exp. Bot., 2005. 56(418): p. 1983-9 [PMID:15967776] Xu CR, et al. Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. Proc. Natl. Acad. Sci. U.S.A., 2005. 102(40): p. 14469-74 [PMID:16176989] Kurata T, et al. Cell-to-cell movement of the CAPRICE protein in Arabidopsis root epidermal cell differentiation. Development, 2005. 132(24): p. 5387-98 [PMID:16291794] Dolan L Positional information and mobile transcriptional regulators determine cell pattern in the Arabidopsis root epidermis. J. Exp. Bot., 2006. 57(1): p. 51-4 [PMID:16317033] Baudry A,Caboche M,Lepiniec L TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana. Plant J., 2006. 46(5): p. 768-79 [PMID:16709193] Kwak SH,Schiefelbein J The role of the SCRAMBLED receptor-like kinase in patterning the Arabidopsis root epidermis. Dev. Biol., 2007. 302(1): p. 118-31 [PMID:17027738] Chen ZH,Nimmo GA,Jenkins GI,Nimmo HG BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis. Biochem. J., 2007. 405(1): p. 191-8 [PMID:17376028] Wang S,Chang Y,Guo J,Chen JG Arabidopsis Ovate Family Protein 1 is a transcriptional repressor that suppresses cell elongation. Plant J., 2007. 50(5): p. 858-72 [PMID:17461792] Dombrecht B, et al. MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis. Plant Cell, 2007. 19(7): p. 2225-45 [PMID:17616737] Tominaga R,Iwata M,Okada K,Wada T Functional analysis of the epidermal-specific MYB genes CAPRICE and WEREWOLF in Arabidopsis. Plant Cell, 2007. 19(7): p. 2264-77 [PMID:17644729] Cominelli E, et al. Expression analysis of anthocyanin regulatory genes in response to different light qualities in Arabidopsis thaliana. J. Plant Physiol., 2008. 165(8): p. 886-94 [PMID:17766004] Ishida T, et al. Arabidopsis TRANSPARENT TESTA GLABRA2 is directly regulated by R2R3 MYB transcription factors and is involved in regulation of GLABRA2 transcription in epidermal differentiation. Plant Cell, 2007. 19(8): p. 2531-43 [PMID:17766401] Morohashi K, et al. Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory events. Plant Physiol., 2007. 145(3): p. 736-46 [PMID:17885086] Gonzalez A,Zhao M,Leavitt JM,Lloyd AM Regulation of the anthocyanin biosynthetic pathway by the TTG1/bHLH/Myb transcriptional complex in Arabidopsis seedlings. Plant J., 2008. 53(5): p. 814-27 [PMID:18036197] Wang Y, et al. Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana. J. Plant Res., 2008. 121(1): p. 87-96 [PMID:18060349] Zhao M,Morohashi K,Hatlestad G,Grotewold E,Lloyd A The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci. Development, 2008. 135(11): p. 1991-9 [PMID:18434419] Dubos C, et al. MYBL2 is a new regulator of flavonoid biosynthesis in Arabidopsis thaliana. Plant J., 2008. 55(6): p. 940-53 [PMID:18532978] Wang S, et al. Comprehensive analysis of single-repeat R3 MYB proteins in epidermal cell patterning and their transcriptional regulation in Arabidopsis. BMC Plant Biol., 2008. 8: p. 81 [PMID:18644155] Gao Y, et al. SAD2 in Arabidopsis functions in trichome initiation through mediating GL3 function and regulating GL1, TTG1 and GL2 expression. J Integr Plant Biol, 2008. 50(7): p. 906-17 [PMID:18713401] Ben Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: a dynamic spatial model. BMC Syst Biol, 2008. 2: p. 98 [PMID:19014692] Li SF, et al. The Arabidopsis MYB5 transcription factor regulates mucilage synthesis, seed coat development, and trichome morphogenesis. Plant Cell, 2009. 21(1): p. 72-89 [PMID:19136646] Wester K, et al. Functional diversity of R3 single-repeat genes in trichome development. Development, 2009. 136(9): p. 1487-96 [PMID:19336467] Kang YH, et al. The MYB23 gene provides a positive feedback loop for cell fate specification in the Arabidopsis root epidermis. Plant Cell, 2009. 21(4): p. 1080-94 [PMID:19395683] Arsovski AA,Villota MM,Rowland O,Subramaniam R,Western TL MUM ENHANCERS are important for seed coat mucilage production and mucilage secretory cell differentiation in Arabidopsis thaliana. J. Exp. Bot., 2009. 60(9): p. 2601-12 [PMID:19401413] Feyissa DN,Løvdal T,Olsen KM,Slimestad R,Lillo C The endogenous GL3, but not EGL3, gene is necessary for anthocyanin accumulation as induced by nitrogen depletion in Arabidopsis rosette stage leaves. Planta, 2009. 230(4): p. 747-54 [PMID:19621239] Marks MD,Wenger JP,Gilding E,Jilk R,Dixon RA Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development. Mol Plant, 2009. 2(4): p. 803-22 [PMID:19626137] Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Qi T, et al. The Jasmonate-ZIM-domain proteins interact with the WD-Repeat/bHLH/MYB complexes to regulate Jasmonate-mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana. Plant Cell, 2011. 23(5): p. 1795-814 [PMID:21551388] Appelhagen I, et al. Leucoanthocyanidin Dioxygenase in Arabidopsis thaliana: characterization of mutant alleles and regulation by MYB-BHLH-TTG1 transcription factor complexes. Gene, 2011. 484(1-2): p. 61-8 [PMID:21683773] Song SK, et al. Cell fate in the Arabidopsis root epidermis is determined by competition between WEREWOLF and CAPRICE. Plant Physiol., 2011. 157(3): p. 1196-208 [PMID:21914815] Balkunde R,Bouyer D,H Nuclear trapping by GL3 controls intercellular transport and redistribution of TTG1 protein in Arabidopsis. Development, 2011. 138(22): p. 5039-48 [PMID:22028035] Gan L,Xia K,Chen JG,Wang S Functional characterization of TRICHOMELESS2, a new single-repeat R3 MYB transcription factor in the regulation of trichome patterning in Arabidopsis. BMC Plant Biol., 2011. 11: p. 176 [PMID:22168948] Tominaga-Wada R,Iwata M,Nukumizu Y,Sano R,Wada T A full-length R-like basic-helix-loop-helix transcription factor is required for anthocyanin upregulation whereas the N-terminal region regulates epidermal hair formation. Plant Sci., 2012. 183: p. 115-22 [PMID:22195584] Zhao H, et al. A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. J. Biol. Chem., 2012. 287(17): p. 14109-21 [PMID:22334670] Chiu LW,Li L Characterization of the regulatory network of BoMYB2 in controlling anthocyanin biosynthesis in purple cauliflower. Planta, 2012. 236(4): p. 1153-64 [PMID:22644767] Tominaga-Wada R,Nukumizu Y,Sato S,Wada T Control of plant trichome and root-hair development by a tomato (Solanum lycopersicum) R3 MYB transcription factor. PLoS ONE, 2013. 8(1): p. e54019 [PMID:23326563] Patra B,Pattanaik S,Yuan L Ubiquitin protein ligase 3 mediates the proteasomal degradation of GLABROUS 3 and ENHANCER OF GLABROUS 3, regulators of trichome development and flavonoid biosynthesis in Arabidopsis. Plant J., 2013. 74(3): p. 435-47 [PMID:23373825] Nukumizu Y,Wada T,Tominaga-Wada R Tomato (Solanum lycopersicum) homologs of TRIPTYCHON (SlTRY) and GLABRA3 (SlGL3) are involved in anthocyanin accumulation. Plant Signal Behav, 2013. 8(7): p. e24575 [PMID:23603939] Qi T,Song S,Xie D Modified bimolecular fluorescence complementation assay to study the inhibition of transcription complex formation by JAZ proteins. Methods Mol. Biol., 2013. 1011: p. 187-97 [PMID:23615997] Kang YH,Song SK,Schiefelbein J,Lee MM Nuclear trapping controls the position-dependent localization of CAPRICE in the root epidermis of Arabidopsis. Plant Physiol., 2013. 163(1): p. 193-204 [PMID:23832626] Liu Z,Shi MZ,Xie DY Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins. Planta, 2014. 239(4): p. 765-81 [PMID:24370633] Qi T, et al. Arabidopsis DELLA and JAZ proteins bind the WD-repeat/bHLH/MYB complex to modulate gibberellin and jasmonate signaling synergy. Plant Cell, 2014. 26(3): p. 1118-33 [PMID:24659329] Nayidu NK, et al. Comparison of five major trichome regulatory genes in Brassica villosa with orthologues within the Brassicaceae. PLoS ONE, 2014. 9(4): p. e95877 [PMID:24755905] Cheng Y, et al. Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases. Elife, 2018. [PMID:24771765] Ranocha P,Francoz E,Burlat V,Dunand C Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion. Plant Signal Behav, 2014. 9(11): p. e977734 [PMID:25531128] Nemie-Feyissa D,Heidari B,Blaise M,Lillo C Analysis of interactions between heterologously produced bHLH and MYB proteins that regulate anthocyanin biosynthesis: quantitative interaction kinetics by Microscale Thermophoresis. Phytochemistry, 2015. 111: p. 21-6 [PMID:25659750] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Song SK,Kwak SH,Chang SC,Schiefelbein J,Lee MM WEREWOLF and ENHANCER of GLABRA3 are interdependent regulators of the spatial expression pattern of GLABRA2 in Arabidopsis. Biochem. Biophys. Res. Commun., 2015. 467(1): p. 94-100 [PMID:26408906] Kwak SH,Song SK,Lee MM,Schiefelbein J TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana. Plant Signal Behav, 2015. 10(12): p. e1103407 [PMID:26451798] Dai X, et al. A single amino acid substitution in the R3 domain of GLABRA1 leads to inhibition of trichome formation in Arabidopsis without affecting its interaction with GLABRA3. Plant Cell Environ., 2016. 39(4): p. 897-907 [PMID:26667588] Friede A, et al. The Second Intron Is Essential for the Transcriptional Control of the Arabidopsis thaliana GLABRA3 Gene in Leaves. Front Plant Sci, 2017. 8: p. 1382 [PMID:28848584] Feng K, et al. An R2R3-MYB transcription factor, OjMYB1, functions in anthocyanin biosynthesis in Oenanthe javanica. Planta, 2018. 247(2): p. 301-315 [PMID:28965159] Wen J, et al. The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions. Plant Signal Behav, 2018. 13(1): p. e1422460 [PMID:29293407]