PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G53170.1

Common Name

ATERF8, ATERF-8, ERF079, ERF8, ERF-8, F12M16.6

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

ERF

Protein Properties

Length: 185aa MW: 20024.8 Da PI: 9.7802

Description

ethylene response factor 8

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G53170.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	59	1.2e-18	30	79	2	55
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 +y+GVr ++ +gr++AeIrdp++ ++r++lg+f+ta++Aa+a++aa++ ++g AT1G53170.1 30 RYRGVRKRP-WGRYAAEIRDPVK---KTRVWLGTFDTAQQAARAYDAAARDFRG 79 59*****.******654...5********************98876 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51032	23.288	30	87	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	2.1E-30	30	86	IPR001471	AP2/ERF domain
Pfam	PF00847	2.8E-12	30	78	IPR001471	AP2/ERF domain
SMART	SM00380	1.4E-34	30	93	IPR001471	AP2/ERF domain
SuperFamily	SSF54171	2.42E-21	30	88	IPR016177	DNA-binding domain
CDD	cd00018	4.51E-19	30	86	No hit	No description
PRINTS	PR00367	3.5E-11	31	42	IPR001471	AP2/ERF domain
PRINTS	PR00367	3.5E-11	53	69	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009873	Biological Process	ethylene-activated signaling pathway
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025034	anatomy	leaf
PO:0025281	anatomy	pollen
PO:0001017	developmental stage	M germinated pollen stage
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007131	developmental stage	seedling development stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 185 aa Download sequence Send to blast
MPNITMGLKP DPVAPTNPTH HESNAAKEIR YRGVRKRPWG RYAAEIRDPV KKTRVWLGTF 60 DTAQQAARAY DAAARDFRGV KAKTNFGVIV GSSPTQSSTV VDSPTAARFI TPPHLELSLG 120 GGGACRRKIP LVHPVYYYNM ATYPKMTTCG VQSESETSSV VDFEGGAGKI SPPLDLDLNL 180 APPAE

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5wx9_A	2e-19	25	86	9	71	Ethylene-responsive transcription factor ERF096
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.4604	0.0	flower

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	42562721	0.0
Genevisible	261315_at	0.0
Expression Atlas	AT1G53170	-
AtGenExpress	AT1G53170	-
ATTED-II	AT1G53170	-

Functional Description ? help Back to Top
Source	Description
TAIR	encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (ATERF-8). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole.
UniProt	Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis-related promoter element. Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11487705}.

Function -- GeneRIF ? help Back to Top
AtERF4 and AtERF8 regulated the expression of many genes involved in the progression of leaf senescence. [PMID: 23629833] Transcriptional repressor ERF8 has dual roles in abscisic acid signaling, pathogen defense and immunity. [PMID: 30261844]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00202	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G53170.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	ethylene

Interaction ? help Back to Top
Source	Intact With
IntAct	Search Q9MAI5

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G53170

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AB036884	0.0	AB036884.1 Arabidopsis thaliana AtERF8 mRNA for ERF transcription factor8, complete cds.
GenBank	AC008007	0.0	AC008007.7 Genomic sequence for Arabidopsis thaliana BAC F12M16 from chromosome I, complete sequence.
GenBank	AC022520	0.0	AC022520.2 Arabidopsis thaliana chromosome I BAC F8L10 genomic sequence, complete sequence.
GenBank	AK117541	0.0	AK117541.1 Arabidopsis thaliana At1g53170 mRNA for putative ethylene responsive element binding factor 8 (ERF8), complete cds, clone: RAFL17-19-H19.
GenBank	BT005401	0.0	BT005401.1 Arabidopsis thaliana clone U50346 putative ethylene responsive element binding factor 8 (At1g53170) mRNA, complete cds.
GenBank	CP002684	0.0	CP002684.1 Arabidopsis thaliana chromosome 1 sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_175725.1	1e-136	ethylene response factor 8
Swissprot	Q9MAI5	1e-137	ERF79_ARATH; Ethylene-responsive transcription factor 8
TrEMBL	A0A178WCR7	1e-133	A0A178WCR7_ARATH; ERF8
STRING	AT1G53170.1	1e-136	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM10	28	1650
Representative plant	OGRP6	16	1718

Link Out ? help Back to Top
Phytozome	AT1G53170.1
Entrez Gene	841751
iHOP	AT1G53170
wikigenes	AT1G53170

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Ohta M,Matsui K,Hiratsu K,Shinshi H,Ohme-Takagi M Repression domains of class II ERF transcriptional repressors share an essential motif for active repression. Plant Cell, 2001. 13(8): p. 1959-68 [PMID:11487705] Seki M, et al. Functional annotation of a full-length Arabidopsis cDNA collection. Science, 2002. 296(5565): p. 141-5 [PMID:11910074] Bray EA Classification of genes differentially expressed during water-deficit stress in Arabidopsis thaliana: an analysis using microarray and differential expression data. Ann. Bot., 2002. 89 Spec No: p. 803-11 [PMID:12102506] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Hu W,Wang Y,Bowers C,Ma H Isolation, sequence analysis, and expression studies of florally expressed cDNAs in Arabidopsis. Plant Mol. Biol., 2003. 53(4): p. 545-63 [PMID:15010618] Wang J, et al. Genomewide nonadditive gene regulation in Arabidopsis allotetraploids. Genetics, 2006. 172(1): p. 507-17 [PMID:16172500] Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Nakano T,Suzuki K,Fujimura T,Shinshi H Genome-wide analysis of the ERF gene family in Arabidopsis and rice. Plant Physiol., 2006. 140(2): p. 411-32 [PMID:16407444] Nemhauser JL,Hong F,Chory J Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses. Cell, 2006. 126(3): p. 467-75 [PMID:16901781] Jung J, et al. The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis. Planta, 2007. 225(3): p. 575-88 [PMID:16937017] Lee J, et al. Analysis of transcription factor HY5 genomic binding sites revealed its hierarchical role in light regulation of development. Plant Cell, 2007. 19(3): p. 731-49 [PMID:17337630] Yamamoto YY, et al. Identification of plant promoter constituents by analysis of local distribution of short sequences. BMC Genomics, 2007. 8: p. 67 [PMID:17346352] Dombrecht B, et al. MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis. Plant Cell, 2007. 19(7): p. 2225-45 [PMID:17616737] Dortay H, et al. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. J. Proteome Res., 2008. 7(9): p. 3649-60 [PMID:18642946] Chen YY,Wang LF,Dai LJ,Yang SG,Tian WM Characterization of HbEREBP1, a wound-responsive transcription factor gene in laticifers of Hevea brasiliensis Muell. Arg. Mol. Biol. Rep., 2012. 39(4): p. 3713-9 [PMID:21761140] Son GH, et al. Ethylene-responsive element-binding factor 5, ERF5, is involved in chitin-induced innate immunity response. Mol. Plant Microbe Interact., 2012. 25(1): p. 48-60 [PMID:21936663] Causier B,Ashworth M,Guo W,Davies B The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol., 2012. 158(1): p. 423-38 [PMID:22065421] Koyama T, et al. A regulatory cascade involving class II ETHYLENE RESPONSE FACTOR transcriptional repressors operates in the progression of leaf senescence. Plant Physiol., 2013. 162(2): p. 991-1005 [PMID:23629833] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Lumba S, et al. A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis. Dev. Cell, 2014. 29(3): p. 360-72 [PMID:24823379] Van den Broeck L, et al. From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress. Mol. Syst. Biol., 2017. 13(12): p. 961 [PMID:29269383] Cao FY, et al. Arabidopsis ETHYLENE RESPONSE FACTOR 8 (ERF8) has dual functions in ABA signaling and immunity. BMC Plant Biol., 2018. 18(1): p. 211 [PMID:30261844] Riechmann JL,Meyerowitz EM The AP2/EREBP family of plant transcription factors. Biol. Chem., 1998. 379(6): p. 633-46 [PMID:9687012]