PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G30970.1
Common NameF17F8.14, SUF4
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 367aa    MW: 39801.5 Da    PI: 8.7845
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G30970.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.10.000593659123
                 EEETTTTEEESSHHHHHHHHHH.T CS
      zf-C2H2  1 ykCpdCgksFsrksnLkrHirt.H 23
                 +kC+ C+k  s+ s ++ H    H
  AT1G30970.1 36 FKCHVCHKKLSTASGMVIHVLQvH 59
                 89*****************87656 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5080812.716766IPR003656Zinc finger, BED-type
SuperFamilySSF576674.2E-51261No hitNo description
SMARTSM00355201235IPR015880Zinc finger, C2H2-like
PROSITE patternPS0002801435IPR007087Zinc finger, C2H2
SMARTSM003550.0843659IPR015880Zinc finger, C2H2-like
PROSITE patternPS0002803859IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009910Biological Processnegative regulation of flower development
GO:0030154Biological Processcell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0042803Molecular Functionprotein homodimerization activity
GO:0046872Molecular Functionmetal ion binding
GO:0046982Molecular Functionprotein heterodimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000014anatomyrosette leaf
PO:0000025anatomyroot tip
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001016developmental stageL mature pollen stage
PO:0001017developmental stageM germinated pollen stage
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 367 aa     Download sequence    Send to blast
MGKKKKRATE KVWCYYCDRE FDDEKILVQH QKAKHFKCHV CHKKLSTASG MVIHVLQVHK  60
ENVTKVPNAK DGRDSTDIEI YGMQGIPPHV LTAHYGEEED EPPAKVAKVE IPSAPLGGVV  120
PRPYGMVYPP QQVPGAVPAR PMYYPGPPMR HPAPVWQMPP PRPQQWYPQN PALSVPPAAH  180
LGYRPQPLFP VQNMGMTPTP TSAPAIQPSP VTGVTPPGIP TSSPAMPVPQ PLFPVVNNSI  240
PSQAPPFSAP LPVGGAQQPS HADALGSADA YPPNNSIPGG TNAHSYASGP NTSGPSIGPP  300
PVIANKAPSN QPNEVYLVWD DEAMSMEERR MSLPKYKVHD ETSQMNSINA AIDRRISESR  360
LAGRMAF
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.252540.0floral meristem| flower| leaf| root| vegetative tissue
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO134307290.0
Genevisible265129_at0.0
Expression AtlasAT1G30970-
AtGenExpressAT1G30970-
ATTED-IIAT1G30970-
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Barely detectable in 3-days-old seedling, and then increases. {ECO:0000269|PubMed:17138694}.
UniprotTISSUE SPECIFICITY: Expressed in root, shoot apex, leaves, stem and flowers. Expressed in expanding leaves, in the vasculature of fully expanded leaves, in the inflorescence, throughout young floral primordia, in the carpels of older flowers and in fertilized ovules. {ECO:0000269|PubMed:17079264, ECO:0000269|PubMed:17138694}.
Functional Description ? help Back to Top
Source Description
TAIREncodes SUF4 (SUPPRESSOR of FRI 4), a putative zinc-finger-containing transcription factor that is required for delayed flowering in winter-annual Arabidopsis. suf4 mutations strongly suppress the late-flowering phenotype of FRI (FRIGIDA) mutants. suf4 mutants also show reduced H3K4 trimethylation at FLC (FLOWERING LOCUS C), a floral inhibitor. SUF4 may act to specifically recruit a putative histone H3 methyltransferase EFS (EARLY FLOWERING IN SHORT DAYS) and the PAF1-like complex to the FLC locus.
UniProtSequence-specific DNA binding factor that recognizes the 5'-CCAAATTTTAAGTTT-3' sequence. Recruits the FRI-C complex to the FLC promoter. Required for FRI-mediated FLC activation, but has no effect on the expression of MAF1, MAF2, MAF3, MAF5, UFC and CO. Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development. {ECO:0000269|PubMed:17079264, ECO:0000269|PubMed:17138694, ECO:0000269|PubMed:19121105, ECO:0000269|PubMed:21282526}.
Function -- GeneRIF ? help Back to Top
  1. SUF4 forms a protein complex with FRI and FRL1 and functions as a transcriptional activator of FLC. [SUF4]
    [PMID: 17138694]
  2. MOM1 contributes to the regulation of SUF4 and EC1 gene expression.
    [PMID: 27920160]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G30970.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Not regulated by photoperiod or vernalization. {ECO:0000269|PubMed:17079264, ECO:0000269|PubMed:17138694}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Interaction ? help Back to Top
Source Intact With
IntActSearch Q9C5G0
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Early flowering. {ECO:0000269|PubMed:17079264, ECO:0000269|PubMed:17138694}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G30970
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF3602770.0AF360277.1 Arabidopsis thaliana putative zinc finger protein (At1g30970) mRNA, complete cds.
GenBankAY0510390.0AY051039.1 Arabidopsis thaliana putative zinc finger protein (At1g30970) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_564369.10.0zinc finger (C2H2 type) family protein
SwissprotQ9C5G00.0SUF4_ARATH; Protein SUPPRESSOR OF FRI 4
TrEMBLA0A178W1B60.0A0A178W1B6_ARATH; SUF4
STRINGAT1G30970.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM76951720
Representative plantOGRP4587810
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  3. Hoth S, et al.
    Monitoring genome-wide changes in gene expression in response to endogenous cytokinin reveals targets in Arabidopsis thaliana.
    FEBS Lett., 2003. 554(3): p. 373-80
    [PMID:14623097]
  4. Gong W, et al.
    Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes.
    Plant Physiol., 2004. 135(2): p. 773-82
    [PMID:15208423]
  5. Kim SY,Michaels SD
    SUPPRESSOR OF FRI 4 encodes a nuclear-localized protein that is required for delayed flowering in winter-annual Arabidopsis.
    Development, 2006. 133(23): p. 4699-707
    [PMID:17079264]
  6. Kim S,Choi K,Park C,Hwang HJ,Lee I
    SUPPRESSOR OF FRIGIDA4, encoding a C2H2-Type zinc finger protein, represses flowering by transcriptional activation of Arabidopsis FLOWERING LOCUS C.
    Plant Cell, 2006. 18(11): p. 2985-98
    [PMID:17138694]
  7. Choi J, et al.
    Resetting and regulation of Flowering Locus C expression during Arabidopsis reproductive development.
    Plant J., 2009. 57(5): p. 918-31
    [PMID:19121105]
  8. Van Leene J, et al.
    Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.
    Mol. Syst. Biol., 2010. 6: p. 397
    [PMID:20706207]
  9. Ko JH, et al.
    Growth habit determination by the balance of histone methylation activities in Arabidopsis.
    EMBO J., 2010. 29(18): p. 3208-15
    [PMID:20711170]
  10. Choi K, et al.
    The FRIGIDA complex activates transcription of FLC, a strong flowering repressor in Arabidopsis, by recruiting chromatin modification factors.
    Plant Cell, 2011. 23(1): p. 289-303
    [PMID:21282526]
  11. Ding L,Kim SY,Michaels SD
    FLOWERING LOCUS C EXPRESSOR family proteins regulate FLOWERING LOCUS C expression in both winter-annual and rapid-cycling Arabidopsis.
    Plant Physiol., 2013. 163(1): p. 243-52
    [PMID:23899645]
  12. Lai Z, et al.
    MED18 interaction with distinct transcription factors regulates multiple plant functions.
    Nat Commun, 2014. 5: p. 3064
    [PMID:24451981]
  13. Bao Z,Zhang N,Hua J
    Endopolyploidization and flowering time are antagonistically regulated by checkpoint component MAD1 and immunity modulator MOS1.
    Nat Commun, 2014. 5: p. 5628
    [PMID:25429892]
  14. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]
  15. Resentini F, et al.
    SUPPRESSOR OF FRIGIDA (SUF4) Supports Gamete Fusion via Regulating Arabidopsis EC1 Gene Expression.
    Plant Physiol., 2017. 173(1): p. 155-166
    [PMID:27920160]