PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G27730.1

Common Name

STZ, T22C5.18, ZAT10

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

C2H2

Protein Properties

Length: 227aa MW: 24614.5 Da PI: 8.3939

Description

salt tolerance zinc finger

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G27730.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.2	6.1e-05	80	102	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ykC+ C+k+Fs+ L H +H AT1G27730.1 80 YKCSVCDKTFSSYQALGGHKASH 102 9***********99999998887 PP
2	zf-C2H2	11	0.0013	136	155	1	20
EEETTTTEEESSHHHHHHHH CS zf-C2H2 1 ykCpdCgksFsrksnLkrHi 20 ++C++C+ksF++ L H AT1G27730.1 136 HVCTICNKSFPSGQALGGHK 155 79*********988776665 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	5.9E-4	80	102	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.003	80	102	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.201	80	107	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	1.24E-9	80	102	No hit	No description
Pfam	PF13912	1.1E-13	80	104	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	82	102	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	1.24E-9	131	158	No hit	No description
SMART	SM00355	0.036	136	158	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	9.411	136	163	IPR007087	Zinc finger, C2H2
Pfam	PF13912	1.6E-13	136	160	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	138	158	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006979	Biological Process	response to oxidative stress
GO:0009409	Biological Process	response to cold
GO:0009414	Biological Process	response to water deprivation
GO:0009611	Biological Process	response to wounding
GO:0009644	Biological Process	response to high light intensity
GO:0009651	Biological Process	response to salt stress
GO:0009737	Biological Process	response to abscisic acid
GO:0010117	Biological Process	photoprotection
GO:0010200	Biological Process	response to chitin
GO:0015979	Biological Process	photosynthesis
GO:0035264	Biological Process	multicellular organism growth
GO:0045892	Biological Process	negative regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0008270	Molecular Function	zinc ion binding
GO:0043565	Molecular Function	sequence-specific DNA binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000034	anatomy	vascular system
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 227 aa Download sequence Send to blast
MALEALTSPR LASPIPPLFE DSSVFHGVEH WTKGKRSKRS RSDFHHQNLT EEEYLAFCLM 60 LLARDNRQPP PPPAVEKLSY KCSVCDKTFS SYQALGGHKA SHRKNLSQTL SGGGDDHSTS 120 SATTTSAVTT GSGKSHVCTI CNKSFPSGQA LGGHKRCHYE GNNNINTSSV SNSEGAGSTS 180 HVSSSHRGFD LNIPPIPEFS MVNGDDEVMS PMPAKKPRFD FPVKLQL

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.24624	0.0	leaf\| root\| seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	1565226	0.0
Genevisible	261648_at	0.0
Expression Atlas	AT1G27730	-
AtGenExpress	AT1G27730	-
ATTED-II	AT1G27730	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in roots, stems and leaves. {ECO:0000269\|PubMed:10806347, ECO:0000269\|PubMed:15333755, ECO:0000269\|PubMed:8662738, ECO:0000269\|PubMed:9132053}.

Functional Description ? help Back to Top
Source	Description
TAIR	Related to Cys2/His2-type zinc-finger proteins found in higher plants. Compensated for a subset of calcineurin deficiency in yeast. Salt tolerance produced by ZAT10 appeared to be partially dependent on ENA1/PMR2, a P-type ATPase required for Li+ and Na+ efflux in yeast. The protein is localized to the nucleus, acts as a transcriptional repressor and is responsive to chitin oligomers. Also involved in response to photooxidative stress.
UniProt	Transcriptional repressor involved in abiotic stress responses. Can repress the stress responsive genes DREB1A and LTI78. Probably involved in jasmonate (JA) early signaling response. May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade. {ECO:0000269\|PubMed:12032082, ECO:0000269\|PubMed:15333755, ECO:0000269\|PubMed:17112521, ECO:0000269\|PubMed:18216250, ECO:0000269\|PubMed:20140232, ECO:0000269\|PubMed:8662738}.

Function -- GeneRIF ? help Back to Top
Zat10 plays a key role as both a positive and a negative regulator of plant defenses. [PMID: 17112521] Data show thatZAT10 overexpression resulted in enhanced tolerance to photoinhibitory light and exogenous H2O2, increased expression of antioxidative genes whose products are targeted to multiple subcellular compartments. [PMID: 18156220] a C(2)H(2)-type zinc finger transcription factor from Arabidopsis, ZAT10, is a substrate of Mitogen-activated protein kinases. [PMID: 22134874] Overall, our findings indicate that H(2) acts as a novel and cytoprotective regulator in coupling ZAT10/12-mediated antioxidant defence and maintenance of ion homeostasis in the improvement of Arabidopsis salt tolerance [PMID: 23185443]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00162	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G27730.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By salt, cold and drought stresses. Down-regulated by gibberellin. {ECO:0000269\|PubMed:10806347, ECO:0000269\|PubMed:11351099, ECO:0000269\|PubMed:12837949, ECO:0000269\|PubMed:15333755, ECO:0000269\|PubMed:17112521, ECO:0000269\|PubMed:8662738}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G32640 (R)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT1G07890(A), AT1G17420(R), AT1G19180(R), AT3G09640(A), AT4G25100(A), AT5G52310(R)

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	abscisic acid

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G27730

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC012375	0.0	AC012375.3 Genomic sequence for Arabidopsis thaliana BAC T22C5 from chromosome I, complete sequence.
GenBank	AF250336	0.0	AF250336.1 Arabidopsis thaliana zinc finger protein STZ/ZAT10 (STZ/ZAT10) mRNA, complete cds.
GenBank	AY034998	0.0	AY034998.1 Arabidopsis thaliana putative salt-tolerance zinc finger protein (At1g27730) mRNA, complete cds.
GenBank	AY063006	0.0	AY063006.1 Arabidopsis thaliana putative salt-tolerance zinc finger protein (At1g27730) mRNA, complete cds.
GenBank	CP002684	0.0	CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
GenBank	X95573	0.0	X95573.1 A.thaliana mRNA for salt-tolerance zinc finger protein.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_174094.1	1e-169	salt tolerance zinc finger
Swissprot	Q96289	1e-170	ZAT10_ARATH; Zinc finger protein ZAT10
TrEMBL	A0A178WMS3	1e-168	A0A178WMS3_ARATH; ZAT10
STRING	AT1G27730.1	1e-169	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1211	28	98
Representative plant	OGRP131	15	149

Link Out ? help Back to Top
Phytozome	AT1G27730.1
Entrez Gene	839666
iHOP	AT1G27730
wikigenes	AT1G27730

Publications ? help Back to Top
Takatsuji H Zinc-finger proteins: the classical zinc finger emerges in contemporary plant science. Plant Mol. Biol., 1999. 39(6): p. 1073-8 [PMID:10380795] Sakamoto H,Araki T,Meshi T,Iwabuchi M Expression of a subset of the Arabidopsis Cys(2)/His(2)-type zinc-finger protein gene family under water stress. Gene, 2000. 248(1-2): p. 23-32 [PMID:10806347] Kleinow T, et al. Functional identification of an Arabidopsis snf4 ortholog by screening for heterologous multicopy suppressors of snf4 deficiency in yeast. Plant J., 2000. 23(1): p. 115-22 [PMID:10929106] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Gong Z, et al. Genes that are uniquely stress regulated in salt overly sensitive (sos) mutants. Plant Physiol., 2001. 126(1): p. 363-75 [PMID:11351099] Lee H, et al. LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase. EMBO J., 2002. 21(11): p. 2692-702 [PMID:12032082] Ogawa M, et al. Gibberellin biosynthesis and response during Arabidopsis seed germination. Plant Cell, 2003. 15(7): p. 1591-604 [PMID:12837949] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Sakamoto H, et al. Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription repressors under drought, cold, and high-salinity stress conditions. Plant Physiol., 2004. 136(1): p. 2734-46 [PMID:15333755] Ramonell K, et al. Loss-of-function mutations in chitin responsive genes show increased susceptibility to the powdery mildew pathogen Erysiphe cichoracearum. Plant Physiol., 2005. 138(2): p. 1027-36 [PMID:15923325] Taki N, et al. 12-oxo-phytodienoic acid triggers expression of a distinct set of genes and plays a role in wound-induced gene expression in Arabidopsis. Plant Physiol., 2005. 139(3): p. 1268-83 [PMID:16258017] Mitsuya Y, et al. Identification of a novel Cys2/His2-type zinc-finger protein as a component of a spermine-signaling pathway in tobacco. J. Plant Physiol., 2007. 164(6): p. 785-93 [PMID:16882456] Mittler R, et al. Gain- and loss-of-function mutations in Zat10 enhance the tolerance of plants to abiotic stress. FEBS Lett., 2006. 580(28-29): p. 6537-42 [PMID:17112521] Panadero J,Hern Overexpression of the calcineurin target CRZ1 provides freeze tolerance and enhances the fermentative capacity of baker's yeast. Appl. Environ. Microbiol., 2007. 73(15): p. 4824-31 [PMID:17557846] Rossel JB, et al. Systemic and intracellular responses to photooxidative stress in Arabidopsis. Plant Cell, 2007. 19(12): p. 4091-110 [PMID:18156220] Pauwels L, et al. Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells. Proc. Natl. Acad. Sci. U.S.A., 2008. 105(4): p. 1380-5 [PMID:18216250] Zhou QY, et al. Soybean WRKY-type transcription factor genes, GmWRKY13, GmWRKY21, and GmWRKY54, confer differential tolerance to abiotic stresses in transgenic Arabidopsis plants. Plant Biotechnol. J., 2008. 6(5): p. 486-503 [PMID:18384508] Ascencio-Ib Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. Plant Physiol., 2008. 148(1): p. 436-54 [PMID:18650403] Wilson PB, et al. The nucleotidase/phosphatase SAL1 is a negative regulator of drought tolerance in Arabidopsis. Plant J., 2009. 58(2): p. 299-317 [PMID:19170934] Zhou X,Hua D,Chen Z,Zhou Z,Gong Z Elongator mediates ABA responses, oxidative stress resistance and anthocyanin biosynthesis in Arabidopsis. Plant J., 2009. 60(1): p. 79-90 [PMID:19500300] Bai L,Zhou Y,Song CP Arabidopsis proline-rich extensin-like receptor kinase 4 modulates the early event toward abscisic acid response in root tip growth. Plant Signal Behav, 2009. 4(11): p. 1075-7 [PMID:20009554] Pauwels L,Goossens A Fine-tuning of early events in the jasmonate response. Plant Signal Behav, 2008. 3(10): p. 846-7 [PMID:20140232] Tseng CC, et al. Editing of accD and ndhF chloroplast transcripts is partially affected in the Arabidopsis vanilla cream1 mutant. Plant Mol. Biol., 2010. 73(3): p. 309-23 [PMID:20143129] Causier B,Ashworth M,Guo W,Davies B The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol., 2012. 158(1): p. 423-38 [PMID:22065421] Nguyen XC, et al. Identification of a C2H2-type zinc finger transcription factor (ZAT10) from Arabidopsis as a substrate of MAP kinase. Plant Cell Rep., 2012. 31(4): p. 737-45 [PMID:22134874] Niu CF, et al. Wheat WRKY genes TaWRKY2 and TaWRKY19 regulate abiotic stress tolerance in transgenic Arabidopsis plants. Plant Cell Environ., 2012. 35(6): p. 1156-70 [PMID:22220579] Mehterov N, et al. Oxidative stress provokes distinct transcriptional responses in the stress-tolerant atr7 and stress-sensitive loh2 Arabidopsis thaliana mutants as revealed by multi-parallel quantitative real-time PCR analysis of ROS marker and antioxidant genes. Plant Physiol. Biochem., 2012. 59: p. 20-9 [PMID:22710144] Xie Y,Mao Y,Lai D,Zhang W,Shen W H(2) enhances arabidopsis salt tolerance by manipulating ZAT10/12-mediated antioxidant defence and controlling sodium exclusion. PLoS ONE, 2012. 7(11): p. e49800 [PMID:23185443] Dubois M, et al. Ethylene Response Factor6 acts as a central regulator of leaf growth under water-limiting conditions in Arabidopsis. Plant Physiol., 2013. 162(1): p. 319-32 [PMID:23553636] Hahn A, et al. Plant core environmental stress response genes are systemically coordinated during abiotic stresses. Int J Mol Sci, 2013. 14(4): p. 7617-41 [PMID:23567274] Xie Y, et al. Roles of NIA/NR/NOA1-dependent nitric oxide production and HY1 expression in the modulation of Arabidopsis salt tolerance. J. Exp. Bot., 2013. 64(10): p. 3045-60 [PMID:23744476] Li C,Chang PP,Ghebremariam KM,Qin L,Liang Y Overexpression of tomato SpMPK3 gene in Arabidopsis enhances the osmotic tolerance. Biochem. Biophys. Res. Commun., 2014. 443(2): p. 357-62 [PMID:24275141] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Zhan GM, et al. Cosuppression of RBCS3B in Arabidopsis leads to severe photoinhibition caused by ROS accumulation. Plant Cell Rep., 2014. 33(7): p. 1091-108 [PMID:24682522] Shi H,Chan Z The cysteine2/histidine2-type transcription factor ZINC FINGER OF ARABIDOPSIS THALIANA 6-activated C-REPEAT-BINDING FACTOR pathway is essential for melatonin-mediated freezing stress resistance in Arabidopsis. J. Pineal Res., 2014. 57(2): p. 185-91 [PMID:24962049] Munekage YN,Inoue S,Yoneda Y,Yokota A Distinct palisade tissue development processes promoted by leaf autonomous signalling and long-distance signalling in Arabidopsis thaliana. Plant Cell Environ., 2015. 38(6): p. 1116-26 [PMID:25293694] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] van Buer J,Cvetkovic J,Baier M Cold regulation of plastid ascorbate peroxidases serves as a priming hub controlling ROS signaling in Arabidopsis thaliana. BMC Plant Biol., 2016. 16(1): p. 163 [PMID:27439459] Corrales AR, et al. Multifaceted role of cycling DOF factor 3 (CDF3) in the regulation of flowering time and abiotic stress responses in Arabidopsis. Plant Cell Environ., 2017. 40(5): p. 748-764 [PMID:28044345] Nguyen HM, et al. Ethanol Enhances High-Salinity Stress Tolerance by Detoxifying Reactive Oxygen Species in Arabidopsis thaliana and Rice. Front Plant Sci, 2017. 8: p. 1001 [PMID:28717360] Geilen K,Heilmann M,Hillmer S,Böhmer M WRKY43 regulates polyunsaturated fatty acid content and seed germination under unfavourable growth conditions. Sci Rep, 2017. 7(1): p. 14235 [PMID:29079824] Liu X, et al. Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis. Mol Plant, 2017. 10(12): p. 1510-1522 [PMID:29107034] Huang K, et al. Arabidopsis calcium-dependent protein kinase AtCPK1 plays a positive role in salt/drought-stress response. Biochem. Biophys. Res. Commun., 2018. 498(1): p. 92-98 [PMID:29196259] Lippuner V,Cyert MS,Gasser CS Two classes of plant cDNA clones differentially complement yeast calcineurin mutants and increase salt tolerance of wild-type yeast. J. Biol. Chem., 1996. 271(22): p. 12859-66 [PMID:8662738] Meissner R,Michael AJ Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs. Plant Mol. Biol., 1997. 33(4): p. 615-24 [PMID:9132053]