PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G18400.1

Common Name

BEE1, BHLH44, EN77, F15H18.11, F15H18.16

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

bHLH

Protein Properties

Length: 260aa MW: 29363.6 Da PI: 6.9192

Description

BR enhanced expression 1

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G18400.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	26	1.7e-08	155	202	4	55
HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +h+ +Er RR +iN+++ L++++P + k + a++L + ++Y++sLq AT1G18400.1 155 SHSLAERVRRGKINERLRCLQDMVPGC----YKAMGMATMLDEIINYVQSLQ 202 8***********************8....355999***********99 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00083	8.01E-10	149	206	No hit	No description
SuperFamily	SSF47459	1.7E-16	149	219	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.364	151	201	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	2.4E-16	151	212	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	7.4E-6	155	202	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	8.8E-9	157	207	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006351	Biological Process	transcription, DNA-templated
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:1902448	Biological Process	positive regulation of shade avoidance
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0005515	Molecular Function	protein binding
GO:0046983	Molecular Function	protein dimerization activity

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 260 aa Download sequence Send to blast
MANFENLSSD FQTIAMDIYS SITQAADLNN NNSNLHFQTF HPSSTSLESL FLHHHQQQLL 60 HFPGNSPDSS NNFSSTSSFL HSDHNIVDET KKRKALLPTL SSSETSGVSD NTNVIATETG 120 SLRRGKRLKK KKEEEDEKER EVVHVRARRG QATDSHSLAE RVRRGKINER LRCLQDMVPG 180 CYKAMGMATM LDEIINYVQS LQNQVEFLSM KLTAASSFYD FNSETDAVDS MQRAKARETV 240 EMGRQTRDGS PVFHLSTWSL

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	126	132	RLKKKKE

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30685839	0.0
Genevisible	261717_at	0.0
Expression Atlas	AT1G18400	-
AtGenExpress	AT1G18400	-
ATTED-II	AT1G18400	-

Functional Description ? help Back to Top
Source	Description
UniProt	Positive regulator of brassinosteroid signaling. {ECO:0000269\|PubMed:12454087}.

Function -- GeneRIF ? help Back to Top
These results provide new insight into the regulatory control of phenylpropanoid metabolism at low temperatures, and reveal that BEE1 and GFR act as important components of the signal transduction chain. [PMID: 27125220]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G18400.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by brassinosteroid, auxin, ethylene and cytokinin, and repressed by abscisic acid. Insensitive to gibberellic acid. {ECO:0000269\|PubMed:12454087}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	brassinosteroid

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT1G25330
IntAct	Search Q8GZ13

Phenotype -- Disruption Phenotype ? help Back to Top
Source	Description
UniProt	DISRUPTION PHENOTYPE: No visible phenotype. Redundant with BEE2 and BEE3. {ECO:0000269\|PubMed:12454087}.

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G18400

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK117269	0.0	AK117269.1 Arabidopsis thaliana At1g18400 mRNA for putative bHLH transcription factor (bHLH044), complete cds, clone: RAFL16-82-F22.
GenBank	AY138253	0.0	AY138253.1 Arabidopsis thaliana putative bHLH transcription factor (BEE1) mRNA, complete cds.
GenBank	BT005268	0.0	BT005268.1 Arabidopsis thaliana At1g18400 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_173276.2	0.0	BR enhanced expression 1
Swissprot	Q8GZ13	0.0	BEE1_ARATH; Transcription factor BEE 1
TrEMBL	A0A178W257	0.0	A0A178W257_ARATH; BEE1
STRING	AT1G18400.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2997	27	65
Representative plant	OGRP58	16	313

Link Out ? help Back to Top
Phytozome	AT1G18400.1
Entrez Gene	838421
iHOP	AT1G18400
wikigenes	AT1G18400

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Seki M, et al. Functional annotation of a full-length Arabidopsis cDNA collection. Science, 2002. 296(5565): p. 141-5 [PMID:11910074] Friedrichsen DM, et al. Three redundant brassinosteroid early response genes encode putative bHLH transcription factors required for normal growth. Genetics, 2002. 162(3): p. 1445-56 [PMID:12454087] Heim MA, et al. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol. Biol. Evol., 2003. 20(5): p. 735-47 [PMID:12679534] Toledo-Ortiz G,Huq E,Quail PH The Arabidopsis basic/helix-loop-helix transcription factor family. Plant Cell, 2003. 15(8): p. 1749-70 [PMID:12897250] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Bailey PC, et al. Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. Plant Cell, 2003. 15(11): p. 2497-502 [PMID:14600211] P The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling. Plant Physiol., 2004. 134(1): p. 101-17 [PMID:14730066] Nemhauser JL,Mockler TC,Chory J Interdependency of brassinosteroid and auxin signaling in Arabidopsis. PLoS Biol., 2004. 2(9): p. E258 [PMID:15328536] Yin Y, et al. A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis. Cell, 2005. 120(2): p. 249-59 [PMID:15680330] Hannah MA,Heyer AG,Hincha DK A global survey of gene regulation during cold acclimation in Arabidopsis thaliana. PLoS Genet., 2005. 1(2): p. e26 [PMID:16121258] Lee BH,Henderson DA,Zhu JK The Arabidopsis cold-responsive transcriptome and its regulation by ICE1. Plant Cell, 2005. 17(11): p. 3155-75 [PMID:16214899] Gao M,Li G,Potter D,McCombie WR,Quiros CF Comparative analysis of methylthioalkylmalate synthase (MAM) gene family and flanking DNA sequences in Brassica oleracea and Arabidopsis thaliana. Plant Cell Rep., 2006. 25(6): p. 592-8 [PMID:16432629] Li L,Jean M,Belzile F The impact of sequence divergence and DNA mismatch repair on homeologous recombination in Arabidopsis. Plant J., 2006. 45(6): p. 908-16 [PMID:16507082] Brodersen P, et al. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant J., 2006. 47(4): p. 532-46 [PMID:16813576] Catala R, et al. The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses. Plant Cell, 2007. 19(9): p. 2952-66 [PMID:17905899] Husbands A,Bell EM,Shuai B,Smith HM,Springer PS LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Nucleic Acids Res., 2007. 35(19): p. 6663-71 [PMID:17913740] Hanada K, et al. Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana. Mol. Biol. Evol., 2011. 28(1): p. 377-82 [PMID:20736450] Poppenberger B, et al. CESTA, a positive regulator of brassinosteroid biosynthesis. EMBO J., 2011. 30(6): p. 1149-61 [PMID:21336258] Crawford BC,Yanofsky MF HALF FILLED promotes reproductive tract development and fertilization efficiency in Arabidopsis thaliana. Development, 2011. 138(14): p. 2999-3009 [PMID:21693516] Arabidopsis Interactome Mapping Consortium Evidence for network evolution in an Arabidopsis interactome map. Science, 2011. 333(6042): p. 601-7 [PMID:21798944] Cifuentes-Esquivel N, et al. The bHLH proteins BEE and BIM positively modulate the shade avoidance syndrome in Arabidopsis seedlings. Plant J., 2013. 75(6): p. 989-1002 [PMID:23763263] Petridis A,Döll S,Nichelmann L,Bilger W,Mock HP Arabidopsis thaliana G2-LIKE FLAVONOID REGULATOR and BRASSINOSTEROID ENHANCED EXPRESSION1 are low-temperature regulators of flavonoid accumulation. New Phytol., 2016. 211(3): p. 912-25 [PMID:27125220]