PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G10480.1

Common Name

T10O24.9, ZFP5

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

C2H2

Protein Properties

Length: 211aa MW: 23590.2 Da PI: 9.1532

Description

zinc finger protein 5

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G10480.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.5	2.5e-05	60	82	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++Cgk F ++ L H++ H AT1G10480.1 60 HECQYCGKEFANSQALGGHQNAH 82 78******************988 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	9.64E-7	58	87	No hit	No description
Gene3D	G3DSA:3.30.160.60	6.2E-6	58	86	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Pfam	PF13912	3.2E-6	59	84	IPR007087	Zinc finger, C2H2
PROSITE profile	PS50157	11.967	60	87	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	62	82	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007275	Biological Process	multicellular organism development
GO:0009736	Biological Process	cytokinin-activated signaling pathway
GO:0009740	Biological Process	gibberellic acid mediated signaling pathway
GO:0010026	Biological Process	trichome differentiation
GO:0048510	Biological Process	regulation of timing of transition from vegetative to reproductive phase
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0008270	Molecular Function	zinc ion binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000230	anatomy	inflorescence meristem
PO:0009005	anatomy	root
PO:0009046	anatomy	flower
PO:0009049	anatomy	inflorescence
PO:0020100	anatomy	hypocotyl
PO:0007611	developmental stage	petal differentiation and expansion stage

Sequence ? help Back to Top
Protein Sequence Length: 211 aa Download sequence Send to blast
MSINPTMSRT GESSSGSSSD KTIKLFGFEL ISGSRTPEIT TAESVSSSTN TTSLTVMKRH 60 ECQYCGKEFA NSQALGGHQN AHKKERLKKK RLQLQARRAS IGYYLTNHQQ PITTSFQRQY 120 KTPSYCAFSS MHVNNDQMGV YNEDWSSRSS QINFGNNDTC QDLNEQSGEM GKLYGVRPNM 180 IQFQRDLSSR SDQMRSINSL DLHLGFAGDA A

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	42561898	0.0
Genevisible	263208_at	0.0
Expression Atlas	AT1G10480	-
AtGenExpress	AT1G10480	-
ATTED-II	AT1G10480	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Highly expressed in roots, young leaves, developing stems, branches, inflorescence meristems, floral meristems and siliques. Expressed at low levels in rosette and cauline leaves. {ECO:0000269\|PubMed:21803862, ECO:0000269\|PubMed:22762888}.

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes a zinc finger protein containing only a single zinc finger.
UniProt	Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin (GA). Acts upstream of GIS, GIS2, ZFP8 and the trichome initiation regulators GL1 and GL3 (PubMed:21803862, PubMed:22301962). Binds the promoter region of ZFP8, which may be a direct target of ZPF5 (PubMed:21803862). Is not involved in the regulation of trichome branching (PubMed:22301962). Modulates root hair initiation and elongation in response to cytokinin and ethylene signals by directly promoting expression of the CAPRICE (CPC) gene (PubMed:22762888). {ECO:0000269\|PubMed:21803862, ECO:0000269\|PubMed:22301962, ECO:0000269\|PubMed:22762888}.

Function -- GeneRIF ? help Back to Top
ZFP8 is the direct target of ZFP5 in controlling epidermal cell differentiation. [PMID: 21803862] show that ZFP5 encodes a protein functionally equivalent to GIS and GIS2 in controlling trichome initiation [PMID: 22301962] ZFP5 integrates various plant hormone cues to control root epidermal cell development in Arabidopsis. [PMID: 22762888]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G10480.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By cytokinin and ethylene. {ECO:0000269\|PubMed:22762888}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Disruption Phenotype ? help Back to Top
Source	Description
UniProt	DISRUPTION PHENOTYPE: Reduced trichome production on sepals, cauline leaves, paraclades and main inflorescence stems. Reduced number and size of root hairs, due to reduced growth rate. {ECO:0000269\|PubMed:21803862, ECO:0000269\|PubMed:22762888}.

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G10480

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC007067	0.0	AC007067.4 Genomic sequence for Arabidopsis thaliana BAC T10O24 from Chromosome 1, complete sequence.
GenBank	ATHZFPE	0.0	L39648.1 Arabidopsis thaliana zinc finger protein (ZFP5) mRNA, complete cds.
GenBank	AY086302	0.0	AY086302.1 Arabidopsis thaliana clone 23664 mRNA, complete sequence.
GenBank	BT024840	0.0	BT024840.1 Arabidopsis thaliana At1g10480 gene, complete cds.
GenBank	CP002684	0.0	CP002684.1 Arabidopsis thaliana chromosome 1 sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_172518.1	1e-158	zinc finger protein 5
Swissprot	Q39264	1e-159	ZFP5_ARATH; Zinc finger protein 5
TrEMBL	A0A178W5E9	1e-157	A0A178W5E9_ARATH; ZFP5
STRING	AT1G10480.1	1e-158	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM7325	25	41
Representative plant	OGRP10209	6	8

Link Out ? help Back to Top
Phytozome	AT1G10480.1
Entrez Gene	837588
iHOP	AT1G10480
wikigenes	AT1G10480

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Dal Bosco C, et al. Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana. J. Biol. Chem., 2004. 279(2): p. 1060-9 [PMID:14576160] Jiao Y, et al. A genome-wide analysis of blue-light regulation of Arabidopsis transcription factor gene expression during seedling development. Plant Physiol., 2003. 133(4): p. 1480-93 [PMID:14605227] Englbrecht CC,Schoof H,B Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome. BMC Genomics, 2004. 5(1): p. 39 [PMID:15236668] Brodersen P, et al. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant J., 2006. 47(4): p. 532-46 [PMID:16813576] Lee DJ, et al. Genome-wide expression profiling of ARABIDOPSIS RESPONSE REGULATOR 7(ARR7) overexpression in cytokinin response. Mol. Genet. Genomics, 2007. 277(2): p. 115-37 [PMID:17061125] Shin R,Jez JM,Basra A,Zhang B,Schachtman DP 14-3-3 proteins fine-tune plant nutrient metabolism. FEBS Lett., 2011. 585(1): p. 143-7 [PMID:21094157] Zhou Z, et al. Zinc finger protein5 is required for the control of trichome initiation by acting upstream of zinc finger protein8 in Arabidopsis. Plant Physiol., 2011. 157(2): p. 673-82 [PMID:21803862] Gaudinier A, et al. Enhanced Y1H assays for Arabidopsis. Nat. Methods, 2011. 8(12): p. 1053-5 [PMID:22037706] Zhou Z,An L,Sun L,Gan Y ZFP5 encodes a functionally equivalent GIS protein to control trichome initiation. Plant Signal Behav, 2012. 7(1): p. 28-30 [PMID:22301962] Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] An L, et al. A zinc finger protein gene ZFP5 integrates phytohormone signaling to control root hair development in Arabidopsis. Plant J., 2012. 72(3): p. 474-90 [PMID:22762888] Zhou Z, et al. Zinc Finger Protein 6 (ZFP6) regulates trichome initiation by integrating gibberellin and cytokinin signaling in Arabidopsis thaliana. New Phytol., 2013. 198(3): p. 699-708 [PMID:23506479] Savage LJ,Imre KM,Hall DA,Last RL Analysis of essential Arabidopsis nuclear genes encoding plastid-targeted proteins. PLoS ONE, 2013. 8(9): p. e73291 [PMID:24023856] Sun L, et al. GLABROUS INFLORESCENCE STEMS3 (GIS3) regulates trichome initiation and development in Arabidopsis. New Phytol., 2015. 206(1): p. 220-30 [PMID:25640859] Yu D, et al. RPN1a, a subunit of the 26S proteasome, controls trichome development in Arabidopsis. Plant Physiol. Biochem., 2015. 88: p. 82-8 [PMID:25676129] Kim SY,Hyoung S,So WM,Shin JS The novel transcription factor TRP interacts with ZFP5, a trichome initiation-related transcription factor, and negatively regulates trichome initiation through gibberellic acid signaling. Plant Mol. Biol., 2018. 96(3): p. 315-326 [PMID:29335898] Tague BW,Goodman HM Characterization of a family of Arabidopsis zinc finger protein cDNAs. Plant Mol. Biol., 1995. 28(2): p. 267-79 [PMID:7599312]