PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G01380.1

Common Name

ETC1, F6F3.18

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

MYB_related

Protein Properties

Length: 83aa MW: 9831.22 Da PI: 7.5234

Description

MYB_related family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G01380.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	28.7	3e-09	36	72	6	44
HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS Myb_DNA-binding 6 teEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 +eE++l+ + k+ G + W++Ia +++ gRt++++ +w AT1G01380.1 36 QEEEDLICRMYKLVGER-WDLIAGRIP-GRTAEEIERFW 72 7************99.*****.******999 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00717	6.8E-6	30	78	IPR001005	SANT/Myb domain
CDD	cd00167	5.09E-6	36	72	No hit	No description
SuperFamily	SSF46689	2.85E-7	36	75	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	9.9E-11	36	73	IPR009057	Homeodomain-like
Pfam	PF00249	4.9E-8	36	73	IPR001005	SANT/Myb domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006357	Biological Process	regulation of transcription from RNA polymerase II promoter
GO:0080147	Biological Process	root hair cell development
GO:1900033	Biological Process	negative regulation of trichome patterning
GO:0005634	Cellular Component	nucleus
GO:0000981	Molecular Function	RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001135	Molecular Function	transcription factor activity, RNA polymerase II transcription factor recruiting
GO:0043565	Molecular Function	sequence-specific DNA binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000037	anatomy	shoot apex
PO:0000263	anatomy	non-hair root epidermal cell
PO:0000293	anatomy	guard cell
PO:0009005	anatomy	root
PO:0020100	anatomy	hypocotyl

Sequence ? help Back to Top
Protein Sequence Length: 83 aa Download sequence Send to blast
MNTQRKSKHL KTNPTIVASS SEEVSSLEWE EIAMAQEEED LICRMYKLVG ERWDLIAGRI 60 PGRTAEEIER FWVMKNHRRS QLR

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	145334946	1e-141
Genevisible	257490_x_at	1e-138
Expression Atlas	AT1G01380	-
AtGenExpress	AT1G01380	-
ATTED-II	AT1G01380	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in developing trichomes and non-root hair cells. {ECO:0000269\|PubMed:15063185, ECO:0000269\|PubMed:15584952}.

Functional Description ? help Back to Top
Source	Description
TAIR	ETC1 is involved in trichome and root hair patterning in Arabidopsis.
UniProt	MYB-type transcription factor involved in epidermal cell fate specification. Acts as a negative regulator of trichome development, by mediating lateral inhibition. Promotes the formation of hair developing cells in H position in root epidermis, probably by inhibiting non-hair cell formation. {ECO:0000269\|PubMed:15063185, ECO:0000269\|PubMed:15584952}.

Function -- GeneRIF ? help Back to Top
Mutations in CPC or TRY delay flowering of cpl3 plants. A mutation in ETC1 did not further delay flowering but reduced plant size. [PMID: 23796522] In an intricate interplay between three partly redundant single R3 MYB proteins, CPC, ETC1, and TRY regulate several developmental, physiological and metabolic processes that are putatively located in different tissues. [PMID: 26022254] Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1) in the root tip were affected in hda6 mutation. [PMID: 26143251] that CPC, TRY and ETC1 are also involved in root hair formation at the root-hypocotyl junction. [PMID: 26339713] The results indicate that, unexpectedly, the ETC1 protein cannot move in the root epidermis from hairless cells to the neighboring cells. [PMID: 28437677]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G01380.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G63650 (A), AT3G27920 (A), AT5G14750 (A), AT5G41315 (A)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT1G79840(R)

Interaction -- BIND ? help Back to Top
Source	Intact With	Description
BIND	AT1G63650	EGL3 interacts with ETC1 (At1g01380).

Interaction ? help Back to Top
Source	Intact With
IntAct	Search Q9LNI5

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G01380

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY519518	1e-139	AY519518.1 Arabidopsis thaliana MYB transcription factor (At1g01380) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_171645.1	2e-55	Homeodomain-like superfamily protein
Swissprot	Q9LNI5	2e-56	ETC1_ARATH; MYB-like transcription factor ETC1
TrEMBL	A0A178WDR4	5e-54	A0A178WDR4_ARATH; ETC1
STRING	AT1G01380.1	8e-55	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM323	28	194
Representative plant	OGRP4207	8	23

Link Out ? help Back to Top
Phytozome	AT1G01380.1
Entrez Gene	838096
iHOP	AT1G01380
wikigenes	AT1G01380

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Kirik V,Simon M,Huelskamp M,Schiefelbein J The ENHANCER OF TRY AND CPC1 gene acts redundantly with TRIPTYCHON and CAPRICE in trichome and root hair cell patterning in Arabidopsis. Dev. Biol., 2004. 268(2): p. 506-13 [PMID:15063185] Serna L A network of interacting factors triggering different cell fates. Plant Cell, 2004. 16(9): p. 2258-63 [PMID:15342905] Zimmermann IM,Heim MA,Weisshaar B,Uhrig JF Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J., 2004. 40(1): p. 22-34 [PMID:15361138] Montiel G,Gantet P,Jay-Allemand C,Breton C Transcription factor networks. Pathways to the knowledge of root development. Plant Physiol., 2004. 136(3): p. 3478-85 [PMID:15542499] Esch JJ,Chen MA,Hillestad M,Marks MD Comparison of TRY and the closely related At1g01380 gene in controlling Arabidopsis trichome patterning. Plant J., 2004. 40(6): p. 860-9 [PMID:15584952] Serna L Epidermal cell patterning and differentiation throughout the apical-basal axis of the seedling. J. Exp. Bot., 2005. 56(418): p. 1983-9 [PMID:15967776] Morohashi K, et al. Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory events. Plant Physiol., 2007. 145(3): p. 736-46 [PMID:17885086] Simon M,Lee MM,Lin Y,Gish L,Schiefelbein J Distinct and overlapping roles of single-repeat MYB genes in root epidermal patterning. Dev. Biol., 2007. 311(2): p. 566-78 [PMID:17931617] Tominaga R, et al. Arabidopsis CAPRICE-LIKE MYB 3 (CPL3) controls endoreduplication and flowering development in addition to trichome and root hair formation. Development, 2008. 135(7): p. 1335-45 [PMID:18305006] Zhao M,Morohashi K,Hatlestad G,Grotewold E,Lloyd A The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci. Development, 2008. 135(11): p. 1991-9 [PMID:18434419] Wang S, et al. Comprehensive analysis of single-repeat R3 MYB proteins in epidermal cell patterning and their transcriptional regulation in Arabidopsis. BMC Plant Biol., 2008. 8: p. 81 [PMID:18644155] Shangguan XX,Xu B,Yu ZX,Wang LJ,Chen XY Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco. J. Exp. Bot., 2008. 59(13): p. 3533-42 [PMID:18711121] Wester K, et al. Functional diversity of R3 single-repeat genes in trichome development. Development, 2009. 136(9): p. 1487-96 [PMID:19336467] Kang YH, et al. The MYB23 gene provides a positive feedback loop for cell fate specification in the Arabidopsis root epidermis. Plant Cell, 2009. 21(4): p. 1080-94 [PMID:19395683] Marks MD,Wenger JP,Gilding E,Jilk R,Dixon RA Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development. Mol Plant, 2009. 2(4): p. 803-22 [PMID:19626137] Bruex A, et al. A gene regulatory network for root epidermis cell differentiation in Arabidopsis. PLoS Genet., 2012. 8(1): p. e1002446 [PMID:22253603] Tominaga-Wada R,Nukumizu Y Expression analysis of an R3-Type MYB transcription factor CPC-LIKE MYB4 (TRICHOMELESS2) and CPL4-Related transcripts in Arabidopsis. Int J Mol Sci, 2012. 13(3): p. 3478-91 [PMID:22489163] Meinke DW A survey of dominant mutations in Arabidopsis thaliana. Trends Plant Sci., 2013. 18(2): p. 84-91 [PMID:22995285] Tominaga-Wada R,Nukumizu Y,Sato S,Wada T Control of plant trichome and root-hair development by a tomato (Solanum lycopersicum) R3 MYB transcription factor. PLoS ONE, 2013. 8(1): p. e54019 [PMID:23326563] Chandrika NN,Sundaravelpandian K,Yu SM,Schmidt W ALFIN-LIKE 6 is involved in root hair elongation during phosphate deficiency in Arabidopsis. New Phytol., 2013. 198(3): p. 709-20 [PMID:23432399] Nukumizu Y,Wada T,Tominaga-Wada R Tomato (Solanum lycopersicum) homologs of TRIPTYCHON (SlTRY) and GLABRA3 (SlGL3) are involved in anthocyanin accumulation. Plant Signal Behav, 2013. 8(7): p. e24575 [PMID:23603939] Tominaga-Wada R,Nukumizu Y,Wada T Flowering is delayed by mutations in homologous genes CAPRICE and TRYPTICHON in the early flowering Arabidopsis cpl3 mutant. J. Plant Physiol., 2013. 170(16): p. 1466-8 [PMID:23796522] Savage N, et al. Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana. PLoS ONE, 2013. 8(10): p. e75452 [PMID:24130712] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Chen CY,Schmidt W The paralogous R3 MYB proteins CAPRICE, TRIPTYCHON and ENHANCER OF TRY AND CPC1 play pleiotropic and partly non-redundant roles in the phosphate starvation response of Arabidopsis roots. J. Exp. Bot., 2015. 66(15): p. 4821-34 [PMID:26022254] Li DX,Chen WQ,Xu ZH,Bai SN HISTONE DEACETYLASE6-Defective Mutants Show Increased Expression and Acetylation of ENHANCER OF TRIPTYCHON AND CAPRICE1 and GLABRA2 with Small But Significant Effects on Root Epidermis Cellular Pattern. Plant Physiol., 2015. 168(4): p. 1448-58 [PMID:26143251] Wada T,Hayashi N,Tominaga-Wada R Root hair formation at the root-hypocotyl junction in CPC-LIKE MYB double and triple mutants of Arabidopsis. Plant Signal Behav, 2015. 10(11): p. e1089372 [PMID:26339713] Huang M,Hu Y,Liu X,Li Y,Hou X Arabidopsis LEAFY COTYLEDON1 controls cell fate determination during post-embryonic development. Front Plant Sci, 2015. 6: p. 955 [PMID:26579186] Wada T,Tominaga-Wada R CAPRICE family genes control flowering time through both promoting and repressing CONSTANS and FLOWERING LOCUS T expression. Plant Sci., 2015. 241: p. 260-5 [PMID:26706076] Hegebarth D,Buschhaus C,Wu M,Bird D,Jetter R The composition of surface wax on trichomes of Arabidopsis thaliana differs from wax on other epidermal cells. Plant J., 2016. 88(5): p. 762-774 [PMID:27496682] Tominaga-Wada R,Kurata T,Wada T Localization of ENHANCER OF TRY AND CPC1 protein in Arabidopsis root epidermis. J. Plant Physiol., 2017. 214: p. 48-52 [PMID:28437677] Tominaga-Wada R,Kurata T,Wada T Localization of the CAPRICE-ENHANCER OF TRY AND CPC1 chimera protein in Arabidopsis root epidermis. Biosci. Biotechnol. Biochem., 2017. 81(9): p. 1762-1767 [PMID:28644769] Tominaga-Wada R,Wada T Extended C termini of CPC-LIKE MYB proteins confer functional diversity in Arabidopsis epidermal cell differentiation. Development, 2017. 144(13): p. 2375-2380 [PMID:28676568] Tominaga-Wada R,Wada T Effect of amino acid substitution of CAPRICE on cell-to-cell movement ability in Arabidopsis root epidermis. Dev. Biol., 2018. 435(1): p. 1-5 [PMID:29337129]