PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_8393_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family E2F/DP
Protein Properties Length: 383aa    MW: 43265.6 Da    PI: 9.4256
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_8393_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.73.9e-232186171
        E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                   rk+ksL+ll+++fl+l+++   + + l+++a +L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  Neem_8393_f_1 21 RKQKSLGLLCSNFLSLYNRDGVELIGLDDAAAKL---GV--ERRRIYDIVNVLESVGVLTRRAKNKYTWKG 86
                   79*****************999************...**..****************************98 PP
2E2F_TDP79.13.9e-25156236171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                    r+eksL+lltq+f++l+ +s+ +++tl+evak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Neem_8393_f_1 156 RREKSLGLLTQNFVRLFVCSDVDMITLDEVAKLLLGDahnssIMRTKVRRLYDIANVLSSMNLIEKthtadTRKPAFRWLG 236
                    689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.0E-261788IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.72E-162084IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.8E-282186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-202286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.107.9E-24151238IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-31156236IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.2E-20158236IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.79E-14158237IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 383 aa     Download sequence    Send to blast
MPQSSSSKAQ DPSSRHYTYS RKQKSLGLLC SNFLSLYNRD GVELIGLDDA AAKLGVERRR  60
IYDIVNVLES VGVLTRRAKN KYTWKGFKAI PRALQELKEE GMRDAFTTFD GNNCAKVSDD  120
EDEDEDDETS SNPNTGSQSD TFNTKSALKS SKTDSRREKS LGLLTQNFVR LFVCSDVDMI  180
TLDEVAKLLL GDAHNSSIMR TKVRRLYDIA NVLSSMNLIE KTHTADTRKP AFRWLGVKKL  240
EIGYADSLIL NESRKRTFGT DVTNTSFKRR KVNSSVNGDI SQSIKMEKQI KVDDLVKVVD  300
RSSLENDAKQ GPRSYQFGPF APASMPEVSS KNNVKQTNDW ESLASTYRPQ YHNQALKDLF  360
SHYVEAWKSW YTEVAGKTIQ QIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-40202283228Transcription factor E2F8
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1253270RKRTFGTDVTNTSFKRRK
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024044442.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-136E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2H5NFI60.0A0A2H5NFI6_CITUN; Uncharacterized protein
STRINGXP_006476685.10.0(Citrus sinensis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-138DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]