PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Neem_7267_f_1

Organism

Azadirachta indica

Taxonomic ID

124943

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

E2F/DP

Protein Properties

Length: 592aa MW: 65777.8 Da PI: 5.1949

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_7267_f_1	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	82.7	3e-26	252	332	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse..............dvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L e +v ++RRiYDi+NVLe+++liekk kn+irwkg Neem_7267_f_1 252 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL--EviiwpltsytveyfNV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 332 6899****************************..779******9999..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	8.1E-27	249	334	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	7.35E-14	252	330	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.1E-29	252	332	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	4.4E-23	254	332	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.20E-44	346	449	No hit	No description
SuperFamily	SSF144074	3.4E-31	346	449	No hit	No description
Pfam	PF16421	3.9E-31	348	447	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 592 aa Download sequence Send to blast
MSGTTRASSC PEPSLPAGPI VLPMRHHLAP VTTKPPFVPS DEYHRLSTTR GAADQQPEVI 60 FVRSPQLRRK TGGNGNDVES DTSMSTKANI RSKAAKRNRS TSQTPLSSTG SRRCDSYLGS 120 NPENLIIYAL KLSKKAGIEK LSIEECRVDV KIRKETLILI KAPKETSLEV PDPDEQLKRK 180 TGMDDNEVES SQWVGSPGLT NISNGSFQTP VSAKGGRVNN RSKATKGNRS GPQTPVSNAG 240 SPATLTPAGS CRYDSSLGLL TKKFINLIKH AEDGILDLNK AAETLEVIIW PLTSYTVEYF 300 NVQKRRIYDI TNVLEGIGLI EKKLKNRIRW KGLDNSTPGE VDGDASLLQA EIENLTMEER 360 RVDDQIREMQ ERLRDLSENE NNRKWLFVTE EDIKTVPCFL NETLIAIKAP HGTTLEVPDP 420 DEAVDYPQRR YRIILRSTMG PIDVYLVSQF EEKFEEMNNV VPAESFSIAC NSVSKENQER 480 GIINVESTRN EIEAEAQHAH QICSDINSSE DFGGGMMKIV PSDVDNDADY WLLSDADVSI 540 TDMWKTDSGV EWNGVNMLHP DFGMSDVCSP RPQTPPSRIS EVPSTDFNST HR

Sequence ? help Back to Top

Protein Sequence Length: 592 aa Download sequence Send to blast

MSGTTRASSC PEPSLPAGPI VLPMRHHLAP VTTKPPFVPS DEYHRLSTTR GAADQQPEVI  60
FVRSPQLRRK TGGNGNDVES DTSMSTKANI RSKAAKRNRS TSQTPLSSTG SRRCDSYLGS  120
NPENLIIYAL KLSKKAGIEK LSIEECRVDV KIRKETLILI KAPKETSLEV PDPDEQLKRK  180
TGMDDNEVES SQWVGSPGLT NISNGSFQTP VSAKGGRVNN RSKATKGNRS GPQTPVSNAG  240
SPATLTPAGS CRYDSSLGLL TKKFINLIKH AEDGILDLNK AAETLEVIIW PLTSYTVEYF  300
NVQKRRIYDI TNVLEGIGLI EKKLKNRIRW KGLDNSTPGE VDGDASLLQA EIENLTMEER  360
RVDDQIREMQ ERLRDLSENE NNRKWLFVTE EDIKTVPCFL NETLIAIKAP HGTTLEVPDP  420
DEAVDYPQRR YRIILRSTMG PIDVYLVSQF EEKFEEMNNV VPAESFSIAC NSVSKENQER  480
GIINVESTRN EIEAEAQHAH QICSDINSSE DFGGGMMKIV PSDVDNDADY WLLSDADVSI  540
TDMWKTDSGV EWNGVNMLHP DFGMSDVCSP RPQTPPSRIS EVPSTDFNST HR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	6e-22	247	333	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00661	PBM	Transfer from Pp3c1_6880	Download

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006481571.1	0.0	transcription factor E2FA isoform X3
Refseq	XP_024038059.1	0.0	transcription factor E2FA isoform X3
Swissprot	Q9FNY0	1e-151	E2FA_ARATH; Transcription factor E2FA
TrEMBL	V4SRJ4	0.0	V4SRJ4_9ROSI; Uncharacterized protein
STRING	XP_006481568.1	0.0	(Citrus sinensis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-155	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]