PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Neem_6964_f_1

Organism

Azadirachta indica

Taxonomic ID

124943

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

WOX

Protein Properties

Length: 279aa MW: 30412 Da PI: 5.9737

Description

WOX family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_6964_f_1	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	26.1	1.5e-08	46	83	2	38
T--SS--HHHHHHHHHHHHH.SSS--HHHHHHHHHHCT CS Homeobox 2 rkRttftkeqleeLeelFek.nrypsaeereeLAkklg 38 ++R+++++eq+++Le+ F++ +p ++e++++ ++l+ Neem_6964_f_1 46 KPRWNPKPEQIRILEAIFNSgMVNPPRDEIRRIRTQLQ 83 89***************99**********99995 PP
2	Wus_type_Homeobox	71.6	1.3e-23	45	94	2	51
Wus_type_Homeobox 2 artRWtPtpeQikiLeelyksGlrtPnkeeiqritaeLeeyGkiedkNVf 51 +++RW+P+peQi+iLe++++sG+++P+++ei+ri+++L+eyG+++d+N + Neem_6964_f_1 45 PKPRWNPKPEQIRILEAIFNSGMVNPPRDEIRRIRTQLQEYGQVGDANAH 94 689*********************************************76 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00086	0.00247	45	88	No hit	No description
Pfam	PF00046	4.0E-6	46	83	IPR001356	Homeobox domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009735	Biological Process	response to cytokinin
GO:0009793	Biological Process	embryo development ending in seed dormancy
GO:0010075	Biological Process	regulation of meristem growth
GO:0005634	Cellular Component	nucleus
GO:0005737	Cellular Component	cytoplasm
GO:0044212	Molecular Function	transcription regulatory region DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 279 aa Download sequence Send to blast
MFKSKPCNAH HHQWQHDINS SLMSTGCHRT SYTSVPGGEE RSPEPKPRWN PKPEQIRILE 60 AIFNSGMVNP PRDEIRRIRT QLQEYGQVGD ANAHNEYLTE PFFFPIQHTG GGIGLTQGFG 120 FSELSNVVQV NQQQLGPCTS LLLSEIMNHG ATKKEEDNMK MQPQLSYTAT TVPSILSIAP 180 ALSTSAATVS SIINPIQGVG ESDPVGHGGA ARSTVFINDV AFEVAAGPFN VREAFGEDAV 240 LINSCGQPVL TNEWGVTLQS LNDGAFYYLV RTFSSSLHA

Functional Description ? help Back to Top
Source	Description
UniProt	Homeodomain transcription factor required for meristem growth and early development (PubMed:15753038). Promotes cell proliferation and prevents premature differentiation in meristematic tissues during postembryonic development (PubMed:15753038). Essential for maintaining tissue growth during embryogenesis (PubMed:17706632). May act by repressing TSS to promote meristematic proliferation (PubMed:21185286). Involved in the transcriptional activation of a subset of cytokinin response factors (PubMed:20110319). May act as a negative regulator of cytokinin signaling in the dark (PubMed:21057190). {ECO:0000269\|PubMed:15753038, ECO:0000269\|PubMed:17706632, ECO:0000269\|PubMed:20110319, ECO:0000269\|PubMed:21057190, ECO:0000303\|PubMed:21185286}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated in the zygote after fertilization by the transcription factor WRKY2. {ECO:0000269\|PubMed:21316593}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006449440.2	4e-84	WUSCHEL-related homeobox 9 isoform X2
Swissprot	Q6X7J4	5e-41	WOX9_ARATH; WUSCHEL-related homeobox 9
TrEMBL	A0A2P5VP30	1e-110	A0A2P5VP30_GOSBA; Uncharacterized protein
STRING	XP_006449440.1	4e-86	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM7206	26	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G33880.1	3e-43	homeobox-3

Publications ? help Back to Top
Wang W, et al. Dwarf Tiller1, a Wuschel-related homeobox transcription factor, is required for tiller growth in rice. PLoS Genet., 2014. 10(3): p. e1004154 [PMID:24625559] Zhu T,Moschou PN,Alvarez JM,Sohlberg JJ,von Arnold S Wuschel-related homeobox 8/9 is important for proper embryo patterning in the gymnosperm Norway spruce. J. Exp. Bot., 2014. 65(22): p. 6543-52 [PMID:25205582] Raines T, et al. The cytokinin response factors modulate root and shoot growth and promote leaf senescence in Arabidopsis. Plant J., 2016. 85(1): p. 134-47 [PMID:26662515] Dolzblasz A, et al. Stem Cell Regulation by Arabidopsis WOX Genes. Mol Plant, 2016. 9(7): p. 1028-39 [PMID:27109605] Blein T,Pautot V,Laufs P Combinations of Mutations Sufficient to Alter Arabidopsis Leaf Dissection. Plants (Basel), 2013. 2(2): p. 230-47 [PMID:27137374]