PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_34327_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family CAMTA
Protein Properties Length: 548aa    MW: 61020.1 Da    PI: 6.381
Description CAMTA family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_34327_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1CG-1177.12.3e-55201363118
            CG-1   3 ke.kkrwlkneeiaaiLenfekheltlelktrpksgsliLynrkkvryfrkDGyswkkkkdgktvrEdhekLKvggvevlycyYahseenptfqr 96 
                     +e + rwl+++ei++iL n++k++lt +++ rp+ gsl+L++rk +ryfrkDG+ w+kkkdgktv+E+hekLK g+++vl+cyYah+e+n++fqr
  Neem_34327_f_1  20 QEaQYRWLRPTEICEILRNYQKFHLTPDPPVRPPAGSLFLFDRKALRYFRKDGHRWRKKKDGKTVKEAHEKLKAGSIDVLHCYYAHGEDNENFQR 114
                     55599****************************************************************************************** PP

            CG-1  97 rcywlLeeelekivlvhylevk 118
                     r+yw+L+ +le+ivlvhy+evk
  Neem_34327_f_1 115 RSYWMLDGQLEHIVLVHYREVK 136
                     *******************986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5143781.85715141IPR005559CG-1 DNA-binding domain
SMARTSM010766.9E-7918136IPR005559CG-1 DNA-binding domain
PfamPF038591.7E-4921134IPR005559CG-1 DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 548 aa     Download sequence    Send to blast
MAQTRRYVPN QQLDLEQILQ EAQYRWLRPT EICEILRNYQ KFHLTPDPPV RPPAGSLFLF  60
DRKALRYFRK DGHRWRKKKD GKTVKEAHEK LKAGSIDVLH CYYAHGEDNE NFQRRSYWML  120
DGQLEHIVLV HYREVKEGYK SGVSRLVADP GSQIESPQTS SARSLVQANS PAPTAHTSHA  180
SGLNKIDWNG QALSSEFEDV DSGNGPGAHS LAQPIYGSMP QNASLVAAGL PDLSRHPPGS  240
WFAGTKFNHG TGSSMWTQIL SSSRNAFNVL DQQQKFYIEQ PGGADFTKNK LTDARLDSNS  300
AVTNIGTSGD KLITDVDVPA VMPSSQGASQ DSSFLFSDKG LDGVRNLTRK TPNPYPLFLL  360
ELGWPGSVKC ALDHPNYAQR AIQGLNNLIN VNHHPVPLEH DFNLSNHQCQ TFSVPETTVA  420
SVAQAENKPK DELGELKKLD SFGRWMDQEI GGDCDDSLMA SDSGNYWNTL DTENDDKEVS  480
SLSHHMQLEI DSLGPSLSQE QLFSIRDFSP DWAYSGVETK ACFWATKSYQ VIPDGAVCLV  540
KLKSLLKS
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3'. Binds calmodulin in a calcium-dependent manner in vitro (PubMed:12218065). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance in association with CAMTA1 and CAMTA2 (PubMed:23581962). Required for the cold-induced expression of DREB1B/CBF1, DREB1C/CBF2, ZAT12 and GOLS3 (PubMed:19270186). Involved in response to cold. Contributes together with CAMTA5 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2 (PubMed:28351986). Involved together with CAMTA2 and CAMTA4 in the positive regulation of a general stress response (GSR) (PubMed:25039701). Involved in the regulation of GSR amplitude downstream of MEKK1 (PubMed:25157030). Involved in the regulation of a set of genes involved in defense responses against pathogens (PubMed:18298954). Involved in the regulation of both basal resistance and systemic acquired resistance (SAR) (PubMed:21900483). Acts as negative regulator of plant immunity (PubMed:19122675, PubMed:21900483, PubMed:22345509, PubMed:28407487). Binds to the promoter of the defense-related gene EDS1 and represses its expression (PubMed:19122675). Binds to the promoter of the defense-related gene NDR1 and represses its expression (PubMed:22345509). Involved in defense against insects (PubMed:23072934, PubMed:22371088). Required for tolerance to the generalist herbivore Trichoplusia ni, and contributes to the positive regulation of genes associated with glucosinolate metabolism (PubMed:23072934). Required for tolerance to Bradysia impatiens larvae. Mediates herbivore-induced wound response (PubMed:22371088). Required for wound-induced jasmonate accumulation (PubMed:23072934, PubMed:22371088). Involved in the regulation of ethylene-induced senescence by binding to the promoter of the senescence-inducer gene EIN3 and repressing its expression (PubMed:22345509). {ECO:0000269|PubMed:12218065, ECO:0000269|PubMed:18298954, ECO:0000269|PubMed:19122675, ECO:0000269|PubMed:19270186, ECO:0000269|PubMed:21900483, ECO:0000269|PubMed:22345509, ECO:0000269|PubMed:22371088, ECO:0000269|PubMed:23072934, ECO:0000269|PubMed:23581962, ECO:0000269|PubMed:25039701, ECO:0000269|PubMed:25157030, ECO:0000269|PubMed:28351986, ECO:0000269|PubMed:28407487, ECO:0000305|PubMed:11925432}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat shock, UVB, salt, wounding, ethylene and methyl jasmonate (PubMed:11162426, PubMed:12218065). Induced by infection with the fungal pathogen Golovinomyces cichoracearum (powdery mildew) and the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000 (PubMed:22345509). {ECO:0000269|PubMed:11162426, ECO:0000269|PubMed:12218065, ECO:0000269|PubMed:22345509}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAM4534658e-38AM453465.2 Vitis vinifera contig VV78X089070.3, whole genome shotgun sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006488760.10.0calmodulin-binding transcription activator 3-like isoform X1
RefseqXP_006488761.10.0calmodulin-binding transcription activator 3-like isoform X1
RefseqXP_024033801.10.0calmodulin-binding transcription activator 3 isoform X1
RefseqXP_024033834.10.0calmodulin-binding transcription activator 3 isoform X1
SwissprotQ8GSA77e-67CMTA3_ARATH; Calmodulin-binding transcription activator 3
TrEMBLV4RXQ30.0V4RXQ3_9ROSI; Uncharacterized protein
STRINGXP_006488760.10.0(Citrus sinensis)
STRINGXP_006419272.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM16526911
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G22300.24e-69signal responsive 1
Publications ? help Back to Top
  1. Zhang L,Du L,Shen C,Yang Y,Poovaiah BW
    Regulation of plant immunity through ubiquitin-mediated modulation of Ca(2+) -calmodulin-AtSR1/CAMTA3 signaling.
    Plant J., 2014. 78(2): p. 269-81
    [PMID:24528504]
  2. Benn G, et al.
    A key general stress response motif is regulated non-uniformly by CAMTA transcription factors.
    Plant J., 2014. 80(1): p. 82-92
    [PMID:25039701]
  3. Rahman H,Yang J,Xu YP,Munyampundu JP,Cai XZ
    Phylogeny of Plant CAMTAs and Role of AtCAMTAs in Nonhost Resistance to Xanthomonas oryzae pv. oryzae.
    Front Plant Sci, 2016. 7: p. 177
    [PMID:26973658]
  4. Benn G, et al.
    Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(31): p. 8855-60
    [PMID:27432993]
  5. Kidokoro S, et al.
    Different Cold-Signaling Pathways Function in the Responses to Rapid and Gradual Decreases in Temperature.
    Plant Cell, 2017. 29(4): p. 760-774
    [PMID:28351986]
  6. Lolle S, et al.
    Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles.
    Cell Host Microbe, 2017. 21(4): p. 518-529.e4
    [PMID:28407487]
  7. Kim YS, et al.
    CAMTA-Mediated Regulation of Salicylic Acid Immunity Pathway Genes in Arabidopsis Exposed to Low Temperature and Pathogen Infection.
    Plant Cell, 2017. 29(10): p. 2465-2477
    [PMID:28982964]
  8. Jacob F, et al.
    A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana.
    New Phytol., 2018. 217(4): p. 1667-1680
    [PMID:29226970]