PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Neem_29359_f_1

Organism

Azadirachta indica

Taxonomic ID

124943

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

E2F/DP

Protein Properties

Length: 374aa MW: 41876.8 Da PI: 4.6296

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_29359_f_1	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	81.7	6.4e-26	70	149	1	70
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse..............dvknkrRRiYDilNVLealnliekkekneirwk 70 r+++sL+llt+kf++l++++e+gi++ln++a++L e +v ++RRiYDi+NVLe+++liekk kn+irwk Neem_29359_f_1 70 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL--EviiwpltsytveyfNV--QKRRIYDITNVLEGIGLIEKKLKNRIRWK 149 6899****************************..779******9999..**************************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.2E-25	67	149	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	6.1E-28	70	150	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	3.67E-14	70	148	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	7.1E-23	72	149	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	1.1E-24	133	231	No hit	No description
CDD	cd14660	4.83E-39	139	231	No hit	No description
Pfam	PF16421	1.9E-25	139	229	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 374 aa Download sequence Send to blast
MDDNEVESSQ WVGSPGLTNI SNGSFQTPVS AKGGRVNNRS KATKGNRSGP QTPVSNAGSP 60 ATLTPAGSCR YDSSLGLLTK KFINLIKHAE DGILDLNKAA ETLEVIIWPL TSYTVEYFNV 120 QKRRIYDITN VLEGIGLIEK KLKNRIRWKE MQERLRDLSE NENNRKWLFV TEEDIKTVPC 180 FLNETLIAIK APHGTTLEVP DPDEAVDYPQ RRYRIILRST MGPIDVYLVS QFEEKFEEMN 240 NVVPAESFSI ACNSVSKENQ ERGIINVEST RNEIEAEAQH AHQICSDINS SEDFGGGMMK 300 IVPSDVDNDA DYWLLSDADV SITDMWKTDS GVEWNGVNML HPDFGMSDVC SPRPQTPPSR 360 ISEVPSTDFN STHR

Sequence ? help Back to Top

Protein Sequence Length: 374 aa Download sequence Send to blast

MDDNEVESSQ WVGSPGLTNI SNGSFQTPVS AKGGRVNNRS KATKGNRSGP QTPVSNAGSP  60
ATLTPAGSCR YDSSLGLLTK KFINLIKHAE DGILDLNKAA ETLEVIIWPL TSYTVEYFNV  120
QKRRIYDITN VLEGIGLIEK KLKNRIRWKE MQERLRDLSE NENNRKWLFV TEEDIKTVPC  180
FLNETLIAIK APHGTTLEVP DPDEAVDYPQ RRYRIILRST MGPIDVYLVS QFEEKFEEMN  240
NVVPAESFSI ACNSVSKENQ ERGIINVEST RNEIEAEAQH AHQICSDINS SEDFGGGMMK  300
IVPSDVDNDA DYWLLSDADV SITDMWKTDS GVEWNGVNML HPDFGMSDVC SPRPQTPPSR  360
ISEVPSTDFN STHR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-21	65	149	2	72	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006481571.1	0.0	transcription factor E2FA isoform X3
Refseq	XP_024038059.1	0.0	transcription factor E2FA isoform X3
Swissprot	Q9FNY0	1e-131	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A067G4E4	0.0	A0A067G4E4_CITSI; Uncharacterized protein
STRING	XP_006481568.1	0.0	(Citrus sinensis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-133	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]