PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_28382_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family HD-ZIP
Protein Properties Length: 563aa    MW: 63661.2 Da    PI: 7.9287
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_28382_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox34.92.7e-1126562656
                    -HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
        Homeobox 26 saeereeLAkklgLterqVkvWFqNrRakek 56
                    ++++r +L+++lgL  rq+k+WFqNrR+++k
  Neem_28382_f_1 26 DEKQRLQLSRELGLAPRQIKFWFQNRRTQMK 56
                    689*************************998 PP
2START181.45.1e-571994202206
                     HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEE CS
           START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla....kaetl 82 
                     +a  a++el+++ + +ep+W+kss    + +n + + + f+++++       ++ea+r+sgvv+m+   lv  ++d + +W e ++     a+t+
  Neem_28382_f_1 199 IAANAMEELLRLLQTNEPLWMKSSadgrDVLNLESYERMFPRANShlknpnVRIEASRDSGVVIMNGLALVDMFMDCN-KWVELFPtivsMAKTI 292
                     67889*******************9999888889999999888889999999**************************.******999999**** PP

                     EEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-E CS
           START  83 evissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehv 170
                     evissg      g lqlm+ elq+lsplvp R+f+++Ry++q ++g w+iv vS d  q+ ++     R++++pSg+li++++ng+skvtwvehv
  Neem_28382_f_1 293 EVISSGmlgthsGSLQLMYEELQVLSPLVPtREFYILRYCQQIEQGLWAIVNVSYDFSQFASQ----YRSHRFPSGCLIQDMPNGYSKVTWVEHV 383
                     ************************************************************986....9*************************** PP

                     E--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
           START 171 dlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                     ++++r p h l+r l++sgla ga +w+atlqr ce+
  Neem_28382_f_1 384 EVEDRAPlHRLYRELIQSGLALGAERWLATLQRMCER 420
                     ***********************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM003891.8E-5662IPR001356Homeobox domain
SuperFamilySSF466891.67E-92565IPR009057Homeodomain-like
PROSITE profilePS5007112.1632658IPR001356Homeobox domain
PfamPF000469.3E-92656IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.603.4E-102663IPR009057Homeodomain-like
CDDcd000862.18E-82659No hitNo description
PROSITE patternPS0002703356IPR017970Homeobox, conserved site
PROSITE profilePS5084853.346189423IPR002913START domain
SuperFamilySSF559618.24E-38190421No hitNo description
CDDcd088751.56E-120193419No hitNo description
SMARTSM002349.1E-49198420IPR002913START domain
PfamPF018522.2E-49199420IPR002913START domain
Gene3DG3DSA:3.30.530.202.8E-8261419IPR023393START-like domain
SuperFamilySSF559617.58E-9441532No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 563 aa     Download sequence    Send to blast
MTAPTHKGER SVTIAILLTR FRDLKDEKQR LQLSRELGLA PRQIKFWFQN RRTQMKAQHE  60
RADNCALRAE NDKIRCENIA IREALKNVIC PSCGGPPVSE DSYFDEQKLR MENTQLKEEL  120
DRVSSIAAKY IGRPISQLPP VQPIHISSLD LTMGSFGSQG IGGPSLDLDL LPGSSSNMPN  180
FPFQQIVLSD MDKSLMTDIA ANAMEELLRL LQTNEPLWMK SSADGRDVLN LESYERMFPR  240
ANSHLKNPNV RIEASRDSGV VIMNGLALVD MFMDCNKWVE LFPTIVSMAK TIEVISSGML  300
GTHSGSLQLM YEELQVLSPL VPTREFYILR YCQQIEQGLW AIVNVSYDFS QFASQYRSHR  360
FPSGCLIQDM PNGYSKVTWV EHVEVEDRAP LHRLYRELIQ SGLALGAERW LATLQRMCER  420
FACLMVSGNS TRDLGGVIPS PDGKRSMMKL AQRMVSNFCT SISTSNSHRW TTLSGLNEVG  480
VRVALHKSTD PGQPNGVVLN AATTFWLPVS PQNVFNFFKD ERTRPQSFFF LFSGTFFPMA  540
MEYKKLPTLQ MGHILATAYP FFV
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024042646.10.0homeobox-leucine zipper protein HDG11
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A2H5PXN70.0A0A2H5PXN7_CITUN; Uncharacterized protein
STRINGXP_006478112.10.0(Citrus sinensis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM30042665
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]