PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ahy009033
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis
Family GRF
Protein Properties Length: 345aa    MW: 37287.1 Da    PI: 8.1441
Description GRF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Ahy#S58471129PU_refUnigeneView CDS
PUT-171a-Arachis_hypogaea-6930894PU_unrefplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRC78.47.1e-25110154145
        WRC   1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkskee 45 
                d+epgrCrRtDGKkWRCs+++++++k+CErH+hrgr+rsrk++e+
  Ahy009033 110 DPEPGRCRRTDGKKWRCSKEAYPDSKYCERHMHRGRNRSRKPVES 154
                79****************************************986 PP

2QLQ64.13.5e-224884137
        QLQ  1 saFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37
               s+FT +Q+q+L++Q+l+yKy++a++PvPp+L+ +iqk
  Ahy009033 48 SPFTVSQWQELEHQALIYKYMVAGLPVPPDLVIPIQK 84
               89*********************************97 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM009511.1E-124884IPR014978Glutamine-Leucine-Glutamine, QLQ
PfamPF088804.9E-164983IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166624.3694984IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166725.762110154IPR014977WRC domain
PfamPF088793.1E-21111153IPR014977WRC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005524Molecular FunctionATP binding
Sequence ? help Back to Top
Protein Sequence    Length: 345 aa     Download sequence    Send to blast
MHPTCLIFGL EALNSTGGGG GVGVGVGGGG GGGCSGGGAG MMSSTSRSPF TVSQWQELEH  60
QALIYKYMVA GLPVPPDLVI PIQKSFDSIS HSFFHHPALG YCSFYGKKVD PEPGRCRRTD  120
GKKWRCSKEA YPDSKYCERH MHRGRNRSRK PVESQSMTQS SSTVTSLTAT TGGSSGTGSY  180
QNLNTITFAN PQGTGSGAEQ THYHLDSIPY GIPSREYRYL QGNKSEGGEQ SFFSKALGSN  240
KELRIETQLE NTLMPTRVAS FSTSRSNNNS ILPGDYLQNS YLSDEHASGE SVKHEGQSLR  300
PFFDEWPRSR DSWSGLEATQ LSMSIPMSAS NFSTASSQSS HGETK
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that plays a role in the regulation of meristematic function in leaves, stems and inflorescences (PubMed:24532604). Transcription activator that plays a regulatory role in grain development (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates grain size by promoting cell division and expansion, leading to increased grain length and width (PubMed:26187814, PubMed:27250747, PubMed:27250749, PubMed:26936408, PubMed:27107174). Positively regulates the expression of genes promoting cell proliferation (PubMed:26187814, PubMed:26936408). Activates the expression of expansin genes to promote cell expansion and grain size (PubMed:27250747). May promote grain size by activating brassinosteroid responses (PubMed:27250747). Component of a network formed by the microRNA396 (miRNA396), the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation (Probable). Component of the miRNA396c-GRF4-GIF1 regulatory module that plays an important role in grain size determination (Probable) (PubMed:27250747, PubMed:27250749, PubMed:27107174). {ECO:0000269|PubMed:24532604, ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747, ECO:0000269|PubMed:27250749, ECO:0000305|PubMed:26187814, ECO:0000305|PubMed:27107174, ECO:0000305|PubMed:27250747, ECO:0000305|PubMed:27250749}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: The microRNA396c negatively regulates GRF4 at the transcriptional level. {ECO:0000269|PubMed:26187814, ECO:0000269|PubMed:26936408, ECO:0000269|PubMed:27107174, ECO:0000269|PubMed:27250747}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015964722.10.0growth-regulating factor 4 isoform X2
RefseqXP_025699765.10.0growth-regulating factor 4 isoform X2
SwissprotQ6ZIK54e-81GRF4_ORYSJ; Growth-regulating factor 4
TrEMBLA0A445D7190.0A0A445D719_ARAHY; Uncharacterized protein
STRINGGLYMA01G44471.11e-170(Glycine max)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G13960.11e-43growth-regulating factor 5
Publications ? help Back to Top
  1. Kikuchi S, et al.
    Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.
    Science, 2003. 301(5631): p. 376-9
    [PMID:12869764]
  2. Kuijt SJ, et al.
    Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX families of transcription factors.
    Plant Physiol., 2014. 164(4): p. 1952-66
    [PMID:24532604]
  3. Hu J, et al.
    A Rare Allele of GS2 Enhances Grain Size and Grain Yield in Rice.
    Mol Plant, 2015. 8(10): p. 1455-65
    [PMID:26187814]
  4. Sun P, et al.
    OsGRF4 controls grain shape, panicle length and seed shattering in rice.
    J Integr Plant Biol, 2016. 58(10): p. 836-847
    [PMID:26936408]
  5. Li S, et al.
    The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice.
    Plant Biotechnol. J., 2016. 14(11): p. 2134-2146
    [PMID:27107174]
  6. Che R, et al.
    Control of grain size and rice yield by GL2-mediated brassinosteroid responses.
    Nat Plants, 2015. 2: p. 15195
    [PMID:27250747]
  7. Duan P, et al.
    Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice.
    Nat Plants, 2015. 2: p. 15203
    [PMID:27250749]