PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Araha.11126s0008.1.p
Organism
Arabidopsis halleri
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 471aa    MW: 53052.4 Da    PI: 9.5676
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Araha.11126s0008.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.91.7e-23103168171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                           rk+ksL+ll+++fl+l+++   +++ l+++a++L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  Araha.11126s0008.1.p 103 RKQKSLGLLCTNFLALYNRDGIEMIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLTRRAKNQYTWKG 168
                           79*****************999************...**..****************************98 PP
2E2F_TDP79.62.8e-25238318171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                           r+eksL+lltq+f+kl+ +se++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  Araha.11126s0008.1.p 238 RREKSLGLLTQNFIKLFICSEARIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 318
                           689**************************************999************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.7E-2699169IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.72E-16102166IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.6E-28103168IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.9E-20104168IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.7E-23236319IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.7E-32238318IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.8E-20240318IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.26E-14240319IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 471 aa     Download sequence    Send to blast
MEMSDMDLTN SASPLNYDTT LPKFGGVLLL RRRRSQKIQI GAQVSSQIPP LSFWKSLQNT  60
ISNSQSQKTS FASIMSDLSP ERFKLPITSM PESSSSLHHS YSRKQKSLGL LCTNFLALYN  120
RDGIEMIGLD DAASKLGVER RRIYDIVNVL ESVGVLTRRA KNQYTWKGFA AIPGALKELQ  180
EEGVKDTFHR FYVNENVKGS DDEDDDEESS QPHSSSQTDS SKPGSLPQSS DPSKIDNRRE  240
KSLGLLTQNF IKLFICSEAR IISLDEAAKL LLGDAHNTSI MRTKVRRLYD IANVLSSMNL  300
IEKTHTLDSR KPAFKWLGYN GEPTFTLSSD LMLLESRKRA FGTDLTNVNV KRSKSSSSSQ  360
ENATERKLKM KKHSTPESSY NKSFDVHEPR HGSRGYHFGP FAPGTGTYPT AGLEDNSRRA  420
FDVENLNSDY RPSYQNQVLK DLFSHYMDAW KTWYSEVTQK NPSPNTSQHR *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A5e-401023103228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAraha.11126s0008.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0042580.0BT004258.1 Arabidopsis thaliana clone RAFL15-19-A14 (R20743) putative DP-E2F protein 1 (At3g48160) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020880368.10.0E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLD7LRJ40.0D7LRJ4_ARALL; Uncharacterized protein
STRINGfgenesh2_kg.5__1169__AT3G48160.20.0(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]