PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aqcoe3G103800.2.p
Organism
Aquilegia coerulea
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Ranunculales; Ranunculaceae; Thalictroideae; Aquilegia
Family E2F/DP
Protein Properties Length: 414aa    MW: 47111.8 Da    PI: 8.3033
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Aqcoe3G103800.2.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.98.5e-2462127171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                        rk+ksL+ll+++fl+l+++   +++ l+++a++L    v  +rRRiYDi+NVLe+++l+++k+kn+++w+g
  Aqcoe3G103800.2.p  62 RKQKSLGLLCTNFLSLYNRDGIDTIGLDDAASKL---GV--ERRRIYDIVNVLESVGLLTRKAKNRYTWIG 127
                        79*****************999************...**..****************************98 PP
2E2F_TDP77.41.4e-24201281171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                        r+eksL+lltq+f+kl+ + e++ v+l+e+a+ L+ e     ++++k+RR+YDi+NVL++lnliek     ++k+++rw g
  Aqcoe3G103800.2.p 201 RREKSLGLLTQNFVKLFICRESNLVSLDEAARFLLGEthhscQMRTKVRRLYDIANVLSSLNLIEKthhaeTRKPAFRWLG 281
                        689******************************************************************999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.8E-2658128IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.91E-1761126IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.3E-2962127IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.1E-2163127IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.109.8E-23199282IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.3E-30201281IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.77E-14203282IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.4E-19203281IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 414 aa     Download sequence    Send to blast
MEEENKALMF SSLHQETSFT RDSLSLKQYS ARKDEEEEEE DQEDIIHLKN DNNGRRHYSY  60
SRKQKSLGLL CTNFLSLYNR DGIDTIGLDD AASKLGVERR RIYDIVNVLE SVGLLTRKAK  120
NRYTWIGFGG IPMALNELKE EGLLENNSYN ATDVTNQAKV LDGEENGGSG SFNSNSSSEQ  180
NGYIPSSVYP KLFLPPKVDN RREKSLGLLT QNFVKLFICR ESNLVSLDEA ARFLLGETHH  240
SCQMRTKVRR LYDIANVLSS LNLIEKTHHA ETRKPAFRWL GLEGTAGHEP SESMESRKRV  300
FGTDLTNTSY KRNKIVSTSD ENVHKKMKVH MKCEDLTDVE NVNWVPQKHH PSKQNPKGVV  360
FGPFRPVDLP KVGENEKKNV KKVQDWETLA SSYRPQYHNQ DVQSRSTAVI KGQ*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A7e-42612733228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010272101.11e-141PREDICTED: E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-107E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2G5D9X90.0A0A2G5D9X9_AQUCA; Uncharacterized protein
STRINGAquca_025_00187.10.0(Aquilegia coerulea)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.12e-99DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]